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pro vyhledávání: '"Carrol Henschel"'
Autor:
Bhushan Samant, Mark Shoemaker, Michael Krimm, Elizabeth Messersmith, Brent Welch, John-Michael Sauer, Linda Chen, Michael S. Dappen, Wenxian Mao, Zhenmei Liao, Ted Yednock, Jenifer L. Smith, Carrol Henschel, Nancy G. Wehner, Lilibeth Dofiles, Ian Gallager, Linda Mutter, Michael A. Pleiss, Mark Dreyer, David A. Quincy, Andrei W. Konradi, Hongbin Zhang, Christopher M. Semko, Kassandra Inez Rossiter, Eric Petersen, George Shopp, Juri Y Fukuda, Brian Wipke, Christopher Vandevert, Frederique Bard, Judevin Lugar, Ying-Zi Xu
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(15)
A series of potent α4β1/α4β7 integrin inhibitors is reported, including an inhibitor 12d with remarkable oral exposure and efficacy in rat models of rheumatoid arthritis and Crohn's disease.