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Kinetic and functional properties of human mitochondrial phosphoenolpyruvate carboxykinase

Autor: Escós, Miriam, Latorre, Pedro, Hidalgo, Jorge, Hurtado-Guerrero, Ramón, Carrodeguas, José Alberto, López-Buesa, Pascual

Publikováno v: In Biochemistry and Biophysics Reports September 2016 7:124-129

Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pylori Drug-Resistant Clinical Strains and in Helicobacter pylori -Infected Mice

Autor: Salillas, Sandra, Alías, Miriam, Michel, Valérie, Mahía, Alejandro, Lucía, Ainhoa, Rodrigues, Liliana, Bueno, Jessica, Galano-Frutos, Juan José, de Reuse, Hilde, Velázquez-Campoy, Adrián, Carrodeguas, José Alberto, Sostres, Carlos, Castillo, Javier, Aínsa, José Antonio, Díaz-De-Villegas, María Dolores, Lanas, Angel, Touati, Eliette, Sancho, Javier

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (13), pp.6102-6115. ⟨10.1021/acs.jmedchem.9b00355⟩
Journal of Medicinal Chemistry, 2019, 62 (13), pp.6102-6115. ⟨10.1021/acs.jmedchem.9b00355⟩

International audience; Helicobacter pylori (Hp) infection is the main cause of peptic ulcer and gastric cancer. Hp eradication rates have fallen due to increasing bacterial resistance to currently used broad-spectrum antimicrobials. We have designed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::13de81b0b0f8b52a52f5338646c837b1
https://hal-pasteur.archives-ouvertes.fr/pasteur-02868148

Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts

Autor: Liggi, Sonia, Drakakis, Georgios, Koutsoukas, Alexios, Cortes-Ciriano, Isidro, Martínez-Alonso, Patricia, Malliavin, Thérèse E, Velazquez-Campoy, Adrian, Brewerton, Suzanne C, Bodkin, Michael J, Evans, David A, Glen, Robert C, Carrodeguas, José Alberto, Bender, Andreas

BACKGROUND: An in silico mechanism-of-action analysis protocol was developed, comprising molecule bioactivity profiling, annotation of predicted targets with pathways and calculation of enrichment factors to highlight targets and pathways more likely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______109::d3651f9538e89d7453243f014c93cc90
https://www.repository.cam.ac.uk/handle/1810/246122

Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pyloriDrug-Resistant Clinical Strains and in Helicobacter pylori-Infected Mice

Autor: Salillas, Sandra, Alías, Miriam, Michel, Valérie, Mahía, Alejandro, Lucía, Ainhoa, Rodrigues, Liliana, Bueno, Jessica, Galano-Frutos, Juan José, De Reuse, Hilde, Velázquez-Campoy, Adrián, Carrodeguas, José Alberto, Sostres, Carlos, Castillo, Javier, Aínsa, José Antonio, Díaz-de-Villegas, María Dolores, Lanas, Ángel, Touati, Eliette, Sancho, Javier

Publikováno v: Journal of Medicinal Chemistry; July 2019, Vol. 62 Issue: 13 p6102-6115, 14p