Prostaglandin E2controls the metabolic adaptation of T cells to the intestinal microenvironment

Autor: Villa, Matteo, Sanin, David E., Apostolova, Petya, Corrado, Mauro, Kabat, Agnieszka M., Cristinzio, Carmine, Regina, Annamaria, Carrizo, Gustavo E., Rana, Nisha, Stanczak, Michal A., Baixauli, Francesc, Grzes, Katarzyna M., Cupovic, Jovana, Solagna, Francesca, Hackl, Alexandra, Globig, Anna-Maria, Hässler, Fabian, Puleston, Daniel J., Kelly, Beth, Cabezas-Wallscheid, Nina, Hasselblatt, Peter, Bengsch, Bertram, Zeiser, Robert, Sagar, Buescher, Joerg M., Pearce, Edward J, Pearce, Erika L.

Publikováno v: bioRxiv

Immune cells must adapt to different environments during the course of an immune response. We studied the adaptation of CD8+T cells to the intestinal microenvironment and how this process shapes their residency in the gut. CD8+T cells progressively r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ddab4261d5973a168ad1dde5cb1d30
https://doi.org/10.1101/2023.03.13.532431

Phosphoinositide acyl chain saturation drives CD8+effector T cell signaling and function

Autor: Edwards-Hicks, Joy, Apostolova, Petya, Buescher, Joerg M., Maib, Hannes, Stanczak, Michal A., Corrado, Mauro, Klein Geltink, Ramon I., Maccari, Maria Elena, Villa, Matteo, Carrizo, Gustavo E., Sanin, David E., Baixauli, Francesc, Kelly, Beth, Curtis, Jonathan D., Haessler, Fabian, Patterson, Annette, Field, Cameron S., Caputa, George, Kyle, Ryan L., Soballa, Melanie, Cha, Minsun, Paul, Harry, Martin, Jacob, Grzes, Katarzyna M., Flachsmann, Lea, Mitterer, Michael, Zhao, Liang, Winkler, Frances, Rafei-Shamsabadi, David Ali, Meiss, Frank, Bengsch, Bertram, Zeiser, Robert, Puleston, Daniel J., O’Sullivan, David, Pearce, Edward J., Pearce, Erika L.

Publikováno v: Nature Immunology; March 2023, Vol. 24 Issue: 3 p516-530, 15p

Prostaglandin E 2 controls the metabolic adaptation of T cells to the intestinal microenvironment.

Autor: Villa M; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany. matteo.villa@medunigraz.at.; Division of Rheumatology and Immunology, Department of Internal Medicine, Medical University of Graz, 8036, Graz, Austria. matteo.villa@medunigraz.at., Sanin DE; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany.; Bloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Apostolova P; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany.; Bloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Medicine I (Hematology and Oncology), University Medical Center Freiburg, 79106, Freiburg, Germany., Corrado M; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany.; Institute for Genetics, University of Cologne, Cologne, Germany., Kabat AM; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany.; Bloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Cristinzio C; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany.; Department of Medical Biotechnology, University of Siena, Siena, Italy., Regina A; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany.; Department of Life Sciences, University of Trieste, 34128, Trieste, Italy., Carrizo GE; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany., Rana N; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany., Stanczak MA; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany., Baixauli F; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany., Grzes KM; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany., Cupovic J; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany., Solagna F; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany., Hackl A; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany., Globig AM; Department of Medicine II, University Medical Center Freiburg, 79106, Freiburg, Germany., Hässler F; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany., Puleston DJ; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany., Kelly B; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany., Cabezas-Wallscheid N; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany., Hasselblatt P; Department of Medicine II, University Medical Center Freiburg, 79106, Freiburg, Germany., Bengsch B; Department of Medicine II, University Medical Center Freiburg, 79106, Freiburg, Germany.; CIBSS Centre for Integrative Biological Signalling Studies, Freiburg, Germany., Zeiser R; Department of Medicine I (Hematology and Oncology), University Medical Center Freiburg, 79106, Freiburg, Germany.; CIBSS Centre for Integrative Biological Signalling Studies, Freiburg, Germany., Sagar; Department of Medicine II, University Medical Center Freiburg, 79106, Freiburg, Germany., Buescher JM; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany., Pearce EJ; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany.; Bloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; CIBSS Centre for Integrative Biological Signalling Studies, Freiburg, Germany.; Faculty of Biology, University of Freiburg, 79104, Freiburg, Germany.; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA., Pearce EL; Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany. epearce6@jhmi.edu.; Bloomberg-Kimmel Institute of Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. epearce6@jhmi.edu.; CIBSS Centre for Integrative Biological Signalling Studies, Freiburg, Germany. epearce6@jhmi.edu.; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. epearce6@jhmi.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Jan 11; Vol. 15 (1), pp. 451. Date of Electronic Publication: 2024 Jan 11.