Zobrazeno 1 - 10
of 1 703
pro vyhledávání: '"Carrier mediated"'
Autor:
Toshihiko Tashima
Publikováno v:
Future Pharmacology, Vol 4, Iss 3, Pp 479-493 (2024)
The membrane impermeability of a drug poses a significant challenge in drug research and development, preventing effective drug delivery to the target site. Specifically, the blood-brain barrier (BBB) presents a formidable obstacle to the delivery of
Externí odkaz:
https://doaj.org/article/257e6c886d204bab932c0bb4c790af5d
Publikováno v:
Biomedicines, Vol 12, Iss 10, p 2302 (2024)
The bloodstream and the central nervous system (CNS) are separated by the blood–brain barrier (BBB), an intricate network of blood vessels. Its main role is to regulate the environment within the brain. The primary obstacle for drugs to enter the C
Externí odkaz:
https://doaj.org/article/fd74146a4f4346b8abd71470761f9934
Autor:
Toshihiko Tashima
Publikováno v:
Future Pharmacology, Vol 3, Iss 4, Pp 742-762 (2023)
While it is true that pharmacotherapy has achieved desired health outcomes, significant unmet medical needs persist in the field of central nervous system (CNS) drugs, particularly for neurodegenerative diseases such as Alzheimer’s disease, as well
Externí odkaz:
https://doaj.org/article/158e53a0b2f244928a0568d056a7753c
Autor:
Bruna Juliana Moreira, Letícia Aparecida Schiave, Roberto Martinez, Samuel Generoso Dias, Cristiane Masetto de Gaitani
Publikováno v:
Green Analytical Chemistry, Vol 7, Iss , Pp 100084- (2023)
In this research, we developed a method for fluconazole (FLU) quantification in plasma using carrier-mediated hollow fiber liquid-phase microextraction (HF-LPME). Briefly, the investigation of six solvents for fiber impregnation, two and three-phases
Externí odkaz:
https://doaj.org/article/9d59ea16759b459fa809d679ae3415da
Publikováno v:
Partial Differential Equations in Applied Mathematics, Vol 8, Iss , Pp 100594- (2023)
In this article, a carrier-mediated transport model is considered. The steady-state non-linear diffusion equations were solved by two effective and accessible analytical methods, Akbari-Ganji and the differential transform methods. Here, we present t
Externí odkaz:
https://doaj.org/article/922036969250419cb661ed093c0e0436
Autor:
Toshihiko Tashima
Publikováno v:
Antibodies, Vol 12, Iss 3, p 43 (2023)
Drug development for neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease has challenging difficulties due to the pharmacokinetic impermeability based on the blood-brain barrier (BBB) as well as
Externí odkaz:
https://doaj.org/article/53f756a743ab47d1a44cc78f91a96a7e
Publikováno v:
View, Vol 3, Iss 1, Pp n/a-n/a (2022)
Abstract The blood–brain barrier (BBB) is a highly regulated and efficient barrier that controls the mass transfer between blood and brain, severely limits brain penetration of systemically administered therapeutics. During the onset and progressio
Externí odkaz:
https://doaj.org/article/885a187b392f43de8eff37cb3a76e182
Autor:
Jinlong Cai, Yongtong Xiong, Xiang Zhu, Jinyu Hu, Yunping Wang, Junkai Li, Jianfeng Wu, Qinglai Wu
Publikováno v:
Molecules, Vol 27, Iss 15, p 4999 (2022)
The Kleier model and Carrier-mediated theory are effective for molecularly designing pesticides with phloem mobility. However, the single Kleier model or Carrier-mediated theory cannot achieve a reliable explanation of the phloem mobility of all exog
Externí odkaz:
https://doaj.org/article/476296225b944851b0e5d98a505852bb
Publikováno v:
Antioxidants, Vol 11, Iss 7, p 1392 (2022)
Paeonol is a naturally occurring phenolic agent that attenuates neurotoxicity in neurodegenerative diseases. We aimed to investigate the antioxidant and protective effects of paeonol and determine its transport mechanism in wild-type (WT; NSC-34/hSOD
Externí odkaz:
https://doaj.org/article/f79c1d4aa421454aa60ab939a4b4ae2f
Autor:
William M. Pardridge
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1283 (2022)
The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914, that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood–brain barrier (BBB). Owing to restricted transport across t
Externí odkaz:
https://doaj.org/article/c6269489b0de40d684315bd8d3065bb8