Výsledky vyhledávání - "Carrier Proteins/genetics/metabolism"

Sci signal

Autor: Vincent Jecko, Thomas Wavasseur, Thierry Couffinhal, Etienne Roux, Raj Nayan Sewduth, Pascale Dufourcq, Héléna Kovacic, Cécile Duplàa, Sylvie Jeaningros, Nicolas Fritsch, Béatrice Jaspard-Vinassa, Mathieu Pernot

Publikováno v: Science Signaling
Science Signaling, American Association for the Advancement of Science, In press, 10, pp.eaag3209. ⟨10.1126/scisignal.aag3209⟩

Endothelial cells serve as a barrier between blood and tissues. Maintenance of the endothelial cell barrier depends on the integrity of intercellular junctions, which is regulated by a polarity complex that includes the ζ isoform of atypical protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a11b29d34f31ad18f4d218660ad5c2
http://hdl.handle.net/20.500.12278/21218

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Drosophila Spag Is the Homolog of RNA Polymerase II-associated Protein 3 (RPAP3) and Recruits the Heat Shock Proteins 70 and 90 (Hsp70 and Hsp90) during the Assembly of Cellular Machineries

Autor: Ioannis Iliopoulos, Nour El Houda Benbahouche, Tore Kempf, Istvan Török, Philippe Meyer, Robert Farkaš, Edouard Bertrand, István Kiss, Julien Henri, Bernard M. Mechler, Bérengère Pradet-Balade, Andrey V. Kajava, Joachim Marhold, Martina Schnölzer

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2014, 289 (9), pp.6236--47. ⟨10.1074/jbc.M113.499608⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (9), pp.6236--47. ⟨10.1074/jbc.M113.499608⟩

The R2TP is a recently identified Hsp90 co-chaperone, composed of four proteins as follows: Pih1D1, RPAP3, and the AAA(+)-ATPases RUVBL1 and RUVBL2. In mammals, the R2TP is involved in the biogenesis of cellular machineries such as RNA polymerases, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e0637b89bada28a508ab1d8fe16075
https://doi.org/10.1074/jbc.m113.499608

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Autologous bone marrow-derived cell transplantation in decompensated alcoholic liver disease: what is the impact on liver histology and gene expression patterns?

Autor: Nathalie Lin-Marq, Laurent Spahr, Nicolas Goossens, Laura Rubbia-Brandt, Sophie Clément, Nicolas Lanthier

Publikováno v: Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-10 (2017)
Stem Cell Research & Therapy, Vol. 8, No 1 (2017) P. 88
Stem Cell Research & Therapy, Vol. 8, no. 1, p. 88 [1-10] (2017)

Background Liver stem cell therapy (SCT) has been suggested as a promising means to improve liver regeneration in advanced liver disease. However, data from trials are heterogeneous, with no systematic histological evaluation. The aim of this study i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e18b6cfa6d41171d3cd99da0eff4db
https://pubmed.ncbi.nlm.nih.gov/28420441

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The role of GRIP1 and ephrin B3 in blood pressure control and vascular smooth muscle cell contractility

Autor: Junzheng Peng, Patricia B. Munroe, Guy Cloutier, Ekatherina Stoyanova, Zhao Qin, Jian-Zhong Shen, Tao Wu, W. Edward C. Bradley, Yujia Wang, Hongyu Luo, Shen-Jiang Hu, Georg Ehret, John Verner Raelson, Jiangping Wu, Zenghui Wu

Publikováno v: Scientific Reports, Vol. 6 (2016) P. 38976
Scientific Reports

Several erythropoietin-producing hepatocellular receptor B family (EPHB) and their ligands, ephrinBs (EFNBs), are involved in blood pressure regulation in animal models. We selected 528 single nucleotide polymorphisms (SNPs) within the genes of EPHB6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c984a2a985e49b583d9f63be3a09e2e

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Chromatin-Bound MDM2 regulates serine metabolism and redox homeostasis independently of p53

Autor: Thierry Levade, Jean-Charles Portais, Romain Riscal, Maud Heuillet, Madi Y. Cissé, Floriant Bellvert, Frédérique Sabourdy, Pierre Thibaut, Eric Bonneil, Emilie Schrepfer, Laurent Le Cam, Giuseppe Arena, Laetitia K. Linares, Jean-Emmanuel Sarry, Imade Ait-Arsa, Jean-Christophe Marine, Florian Rambow, Charles Vincent

Publikováno v: Molecular Cell
Molecular Cell, 2016, 62 (6), pp.890-902. ⟨10.1016/j.molcel.2016.04.033⟩
Molecular Cell, Elsevier, 2016, 62 (6), pp.890-902. ⟨10.1016/j.molcel.2016.04.033⟩

The mouse double minute 2 (MDM2) oncoprotein is recognized as a major negative regulator of the p53 tumor suppressor, but growing evidence indicates that its oncogenic activities extend beyond p53. Here, we show that MDM2 is recruited to chromatin in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4544e00da2461a9c18041ad9492c37dd
https://hal.science/hal-01886397

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TonB-dependent receptor repertoire of Pseudomonas aeruginosa for uptake of siderophore-drug conjugates

Autor: Lena Mazza, Lucile Moynié, Alexandre Luscher, Dirk Bumann, Thilo Köhler, James H. Naismith, Pamela Saint Auguste, Daniel Pletzer

Publikováno v: 'Antimicrobial Agents and Chemotherapy ', vol: 62, pages: e00097-18-1-e00097-18-11 (2018)
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, Vol. 62, No 6 (2018) pp. e00097-18

The conjugation of siderophores to antimicrobial molecules is an attractive strategy to overcome the low outer membrane permeability of Gram-negative bacteria. In this Trojan horse approach, the transport of drug conjugates is redirected via TonB-dep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69a3a25ad4ea849316b3621b9867ed1
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:51208

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HAT cofactor Trrap regulates the mitotic checkpoint by modulation of Mad1 and Mad2 expression

Autor: Zhao-Qi Wang, Cyrille Cuenin, Rabih Murr, Hai Li, Zdenko Herceg

Publikováno v: EMBO Journal, Vol. 23, No 24 (2004) pp. 4824-34

As a component of chromatin-modifying complexes with histone acetyltransferase (HAT) activity, TRRAP has been shown to be involved in various cellular processes including gene transcription and oncogenic transformation. Inactivation of Trrap, the mur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a76af22b19681fabc336fa131eec11
https://doi.org/10.1038/sj.emboj.7600479

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COPD Results in a Reduction in UCP3 Long mRNA and UCP3 Protein Content in Types I and IIa Skeletal Muscle Fibers

Autor: Denis Richard, Aaron P. Russell, Richard Debigaré, Giacomo Gastaldi, Annie Michaud, Jean-Paul Giacobino, François Maltais, Pierre LeBlanc, Patrick Muzzin, Astrid Melotti, Emmanuel Somm, Oliver Hartley

Publikováno v: Journal of Cardiopulmonary Rehabilitation, Vol. 24, No 5 (2004) pp. 332-9

Findings recently have shown coupling protein-3 (UCP3) content to be decreased in the skeletal muscle of patients with chronic obstructive pulmonary disease (COPD). Uncoupling protein-3 mRNA exists as two isoforms: long (UCP3L) and short (UCP3S). The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351a3c3f86089654ad93c39e8600e344
https://doi.org/10.1097/00008483-200409000-00009

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Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in β cells

Autor: Hisamitsu Ishihara, Lester R. Drewes, Claes B. Wollheim, Haiyan Wang

Publikováno v: Journal of Clinical Investigation, Vol. 104, No 11 (1999) pp. 1621-9

Previous investigations revealed low activities of lactate dehydrogenase (LDH) and plasma membrane monocarboxylate transporters (MCT) in the pancreatic beta cell. In this study the significance of these characteristics was explored by overexpressing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ca5e09b384b3443a3f11c9ab9c839e
https://doi.org/10.1172/jci7515

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