Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Carrie-Lynn M. Soltys"'
Autor:
Miranda M. Sung, Karen Madsen, Jonathan D. Schertzer, Suresh C. Bairwa, Nirmal Parajuli, Carrie-Lynn M. Soltys, Ty T. Kim, Jason R.B. Dyck, Jody Levasseur, David S. Wishart
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 315:E511-E519
Oral administration of resveratrol attenuates several symptoms associated with the metabolic syndrome, such as impaired glucose homeostasis and hypertension. Recent work has shown that resveratrol can improve glucose homeostasis in obesity via change
Autor:
John M. Seubert, Kelvin E. Jones, Jonathan D. Schertzer, Ian M. Robertson, Carrie-Lynn M. Soltys, Victor Samokhvalov, David Fung, Nikole J. Byrne, Jody Levasseur, Neil Tyreman, Miranda M. Sung, Emmanuel Denou, Ty T. Kim, Jason R.B. Dyck
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 312:H842-H853
We investigated whether treatment of mice with established pressure overload-induced heart failure (HF) with the naturally occurring polyphenol resveratrol could improve functional symptoms of clinical HF such as fatigue and exercise intolerance. C57
Autor:
Ian M. Robertson, Carrie-Lynn M. Soltys, Donna L. Beker, Jason R.B. Dyck, Grant Masson, Miranda M. Sung, Shereen M. Hamza, Nobutoshi Matsumura
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 312:H561-H570
Since left ventricular hypertrophy (LVH) increases the susceptibility for the development of other cardiac conditions, pharmacotherapy that mitigates pathological cardiac remodeling may prove to be beneficial in patients with LVH. Previous work has s
Autor:
Grant Masson, David S. Wishart, Shereen M. Hamza, Heekuk Park, Karen L. Madsen, Ty T. Kim, Jason R.B. Dyck, Jonathan D. Schertzer, Nikole J. Byrne, Carrie-Lynn M. Soltys, Miranda M. Sung, Emmanuel Denou
Publikováno v:
Diabetes. 66:418-425
Oral administration of resveratrol is able to improve glucose homeostasis in obese individuals. Herein we show that resveratrol ingestion produces taxonomic and predicted functional changes in the gut microbiome of obese mice. In particular, changes
Autor:
Nobutoshi Matsumura, Grant Masson, Sherif M. Shoieb, Nirmal Parajuli, Zaid H. Maayah, Donna L. Beker, Shingo Takahara, Jason R.B. Dyck, Nikole J. Byrne, Carrie-Lynn M. Soltys, Ayman O.S. El-Kadi
Publikováno v:
Journal of molecular and cellular cardiology. 125
Numerous epidemiological studies have demonstrated that approximately 40% of myocardial infarctions (MI) are associated with heart failure (HF). Resveratrol, a naturally occurring polyphenol, has been shown to be beneficial in the treatment of MI-ind
Autor:
Marianne K. O. Grant, Alessandro Bartolomucci, Carrie-Lynn M. Soltys, Nirmal Parajuli, Beshay N M Zordoky, Maria Razzoli, Nobutoshi Matsumura, Ian M. Robertson, Shereen M. Hamza, Jason R.B. Dyck, Donna L. Beker
Publikováno v:
Cardiovascular research. 114(10)
Aims Doxorubicin (DOX) is among the most effective chemotherapies used in paediatric cancer patients. However, the clinical utility of DOX is offset by its well-known cardiotoxicity, which often does not appear until later in life. Since hypertension
Autor:
Fei Gao, Jason R.B. Dyck, Nancy Smith, Shereen M. Hamza, Peter E. Light, Patrick E. MacDonald, Carrie-Lynn M. Soltys, Miranda M. Sung
Publikováno v:
Biochimica et biophysica acta. General subjects. 1861(2)
Background Although insulin resistance (IR) is a key factor in the pathogenesis of type 2 diabetes (T2D), the precise role of insulin in the development of IR remains unclear. Therefore, we investigated whether chronic basal insulin infusion is causa
Publikováno v:
Journal of Molecular Medicine. 89:291-302
Recent evidence has suggested that activation of AMP-activated protein kinase (AMPK) induced by short-term caloric restriction (CR) protects against myocardial ischemia-reperfusion (I/R) injury. Because AMPK plays a central role in regulating energy
Autor:
Jason R.B. Dyck, Debby P.Y. Koonen, Martin E. Young, René L. Jacobs, Huy Ong, Carrie Lynn M Soltys, Maria Febbraio, Dennis E. Vance
Publikováno v:
Diabetes. 56:2863-2871
OBJECTIVE—The etiology of type 2 diabetes often involves diet-induced obesity (DIO), which is associated with elevated plasma fatty acids and lipoprotein associated triglycerides. Since aberrant hepatic fatty acid uptake may contribute to this, we
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 290:H2472-H2479
AMP-activated protein kinase (AMPK) plays a major role in the regulation of cardiac energy substrate utilization and can be negatively regulated by Akt activation in the heart. It has recently been shown that Akt directly phosphorylates AMPKα1/α2 o