Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Carrie-Anne Molyneaux"'
Publikováno v:
Biochemical Pharmacology. 71:61-68
Arylpiperazines in which the terminal secondary amino group is unsubstituted were found to display a mefloquine-type antimalarial behavior in being significantly more potent against the chloroquine-resistant (W2 and FCR3) strains of Plasmodium falcip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de681d4e3299aeae7f691067a410814
https://doi.org/10.1016/j.bcp.2005.10.023
https://doi.org/10.1016/j.bcp.2005.10.023
Autor:
Stephanie Maine, Niall M. B. Martin, Marc Geoffrey Hummersone, Carrie-Anne Molyneaux, Christine Bailey, Sharon Maguire, Frederic Georges Marie Leroux, Hermann Gesine Johanna, Graeme C. M. Smith, Ian Hickson, Mar Jimenez Quesada, James R. Pullen, Heather Mary Ellen Duggan, Keith Allan Menear, Peter D. Edwards, Martin Pass, Sylvie Gomez, Lisa Smith, Jan Drzewiecki, Karine Malagu, Armelle Le Gall
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(20)
We describe a novel series of potent inhibitors of the kinase activity of mTOR. The compounds display good selectivity relative to other PI3K-related kinase family members and, in cellular assays, inhibit both mTORC1 and mTORC2 complexes and exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e97b020323b939309b4dfc7c6e5fdc
https://pubmed.ncbi.nlm.nih.gov/19762236
https://pubmed.ncbi.nlm.nih.gov/19762236