Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Carrie Wittmer"'
Autor:
Briana Spolding, Timothy Connor, Carrie Wittmer, Lelia L F Abreu, Antony Kaspi, Mark Ziemann, Gunveen Kaur, Adrian Cooper, Shona Morrison, Scott Lee, Andrew Sinclair, Yann Gibert, James L Trevaskis, Jonathon D Roth, Assam El-Osta, Richard Standish, Ken Walder
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92656 (2014)
BACKGROUND AND AIMS: A major impediment to establishing new treatments for non-alcoholic steatohepatitis is the lack of suitable animal models that accurately mimic the biochemical and metabolic characteristics of the disease. The aim of this study w
Externí odkaz:
https://doaj.org/article/13a67a5e3d2a4746890cfefb42e46c36
Autor:
James L Trevaskis, Christine M Mack, Chengzao Sun, Christopher J Soares, Lawrence J D'Souza, Odile E Levy, Diane Y Lewis, Carolyn M Jodka, Krystyna Tatarkiewicz, Bronislava Gedulin, Swati Gupta, Carrie Wittmer, Michael Hanley, Bruce Forood, David G Parkes, Soumitra S Ghosh
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78154 (2013)
Combination therapy is being increasingly used as a treatment paradigm for metabolic diseases such as diabetes and obesity. In the peptide therapeutics realm, recent work has highlighted the therapeutic potential of chimeric peptides that act on two
Externí odkaz:
https://doaj.org/article/45ac3705572548328d3eb17134e3c0a8
Autor:
Eliezer Masliah, Douglas W. Bonhaus, Diana L. Price, Julian L Wong, Emily M. Stocking, Asma Khan, Carrie Wittmer, Martin B. Gill, Jon K Bowden-Verhoek, Wolfgang Wrasidlo, Robert Johnson, Srinivasa Reddy Natala, Amy Paulino, Michelle Maile, Keith Tatsukawa
Publikováno v:
Brain : a journal of neurology. 144(12)
NPT520-34 is a clinical stage, small molecule being developed for the treatment of Parkinson’s disease and other neurodegenerative disorders. The therapeutic potential of NPT520-34 was first suggested by findings from cell-based assays of alpha-syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e511f218001776f88c513c77a598a244
https://pubmed.ncbi.nlm.nih.gov/34117864
https://pubmed.ncbi.nlm.nih.gov/34117864
Autor:
Peter S. Griffin, Jonathan D. Roth, Jennifer Athanacio, James L. Trevaskis, David G. Parkes, Carrie Wittmer
Publikováno v:
Obesity Science & Practice
SummaryObjective Co-administration of amylin and leptin induces synergistic and clinically meaningful (>10%) weight loss that is attenuated as the degree of obesity increases. We explored whether calorie restriction (CR) could restore amylin/leptin s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c1c35b447ddb7231ee4eeb2cf6a049b
https://doi.org/10.1002/osp4.62
https://doi.org/10.1002/osp4.62
He calls me into his office and closes the door... to promote me. He promotes me again and again. I am wild with ecstasy. Imagine a world where all erotica was written by feminists: Their daydreams include equal pay, a gender-balanced Congress, and T
Autor:
Bruce Forood, David G. Parkes, Jennifer Athanacio, Pete Griffin, Krystyna Tatarkiewicz, Manoj P. Samant, C.-H. Teng, Chengzao Sun, Yan Wang, Lawrence J. D'souza, James L. Trevaskis, Carrie Wittmer, J. D. Roth
Publikováno v:
Diabetes, Obesity and Metabolism. 17:61-73
Aim To test the impact of cholecystokinin (CCK) plus either amylin or a glucagon-like peptide-1 receptor (GLP-1R) agonist on metabolic variables in diet-induced obese (DIO) rodents. Methods A stabilized acetylated version of CCK-8 (Ac-Y*-CCK-8), sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6794c9e33f58c6d7977b395c3ef2fcbe
https://doi.org/10.1111/dom.12390
https://doi.org/10.1111/dom.12390
Autor:
Pete Griffin, Jason R. Clapper, Jonathan D. Roth, Lawrence J. D'souza, Carrie Wittmer, David G. Parkes, Jennifer Athanacio
Publikováno v:
European Journal of Pharmacology. 698:292-298
Antagonism of opioid systems (e.g., with naltrexone) has been explored as an anti-obesity strategy, and is particularly effective when co-administered with dual inhibitors of dopamine and norepinephrine reuptake (e.g., bupropion). Previously, we demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0653f76f793bd5b852466d0ca27b929c
https://doi.org/10.1016/j.ejphar.2012.11.010
https://doi.org/10.1016/j.ejphar.2012.11.010
Autor:
Brent A. Neuschwander-Tetri, David G. Parkes, Peter S. Griffin, James Napora, Carrie S. Dolman, Elizabeth M. Brunt, Jonathan D. Roth, Mary Erickson, James L. Trevaskis, Carrie Wittmer
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 302:G762-G772
These preclinical studies aimed to 1) increase our understanding the dietary induction of nonalcoholic steatohepatitis (NASH), and, 2) further explore the utility and mechanisms of glucagon-like peptide-1 receptor (GLP-1R) agonism in NASH. We compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63abb343cedd36775c20d42439416ed
https://doi.org/10.1152/ajpgi.00476.2011
https://doi.org/10.1152/ajpgi.00476.2011
Autor:
Yu Zhao, James L. Trevaskis, James M. Reynolds, Peter S. Griffin, Carrie Wittmer, David G. Parkes, J K Wilson, Victoria F. Turek, Christine M. Mack, Jonathan D. Roth
Publikováno v:
Endocrinology. 151:5657-5668
In rodents, ovariectomy (OVX) elicits weight gain and diminished responsiveness to homeostatic signals. Here we characterized the response of obese OVX rats to peripheral amylin. Rats received sham surgery (SHAM), OVX, or OVX with hormonal replacemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8630f0e8123cd30a883f6b673b26343
https://doi.org/10.1210/en.2010-0590
https://doi.org/10.1210/en.2010-0590
Autor:
Soumitra S. Ghosh, John Herich, Carrie Wittmer, Michelle D. Hendricks, Carolyn Lowe, Christiane Villescaz, Joseph S. Heilig, Carrie S. Dolman, Jason R. Clapper, Guibao Gu, Jonathan D. Roth, Jennifer Athanacio
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 305(7)
Shortcomings of previously reported preclinical models of nonalcoholic steatohepatitis (NASH) include inadequate methods used to induce disease and assess liver pathology. We have developed a dietary model of NASH displaying features observed clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6affc9688d6ce28310e3b281d237cb1
https://pubmed.ncbi.nlm.nih.gov/23938451
https://pubmed.ncbi.nlm.nih.gov/23938451