Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Carrie S. Dolman"'
Autor:
Brent A. Neuschwander-Tetri, David G. Parkes, Peter S. Griffin, James Napora, Carrie S. Dolman, Elizabeth M. Brunt, Jonathan D. Roth, Mary Erickson, James L. Trevaskis, Carrie Wittmer
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 302:G762-G772
These preclinical studies aimed to 1) increase our understanding the dietary induction of nonalcoholic steatohepatitis (NASH), and, 2) further explore the utility and mechanisms of glucagon-like peptide-1 receptor (GLP-1R) agonism in NASH. We compare
Autor:
Andreas G. Niethammer, Rong Xiang, Ralph A. Reisfeld, Steve Silletti, F. James Primus, Carrie S. Dolman, Stephen D. Gillies, Holger N. Lode, J. Michael Ruehlmann
Publikováno v:
The Journal of Immunology. 167:4560-4565
A carcinoembryonic Ag (CEA)-based DNA vaccine encoding both CEA and CD40 ligand trimer achieved effective tumor-protective immunity against murine colon carcinoma in CEA-transgenic mice by activating both naive T cells and dendritic cells. Peripheral
Autor:
Rong Xiang, Torsten Dreier, Ralph A. Reisfeld, Carrie S. Dolman, Holger N. Lode, Angray S. Kang
Publikováno v:
Bioconjugate Chemistry. 9:482-489
Localized cytokine therapies with recombinant monoclonal antibody-cytokine fusion proteins, designated immunocytokines, have become of increasing interest for tumor immunotherapy, since they direct immunomodulatory cytokines into the tumor microenvir
Autor:
Rong Xiang, Ralph A. Reisfeld, Nissi Varki, Carrie S. Dolman, Stephen D. Gillies, Holger N. Lode
Publikováno v:
JNCI Journal of the National Cancer Institute. 89:1586-1594
BACKGROUND Advanced (stage 4) cases of neuroblastoma, a childhood cancer of the nervous system, are associated with high relapse rates, even after intensive chemotherapy, radiotherapy, and autologous bone marrow transplantation. Therefore, the use of
Autor:
Soumitra S. Ghosh, John Herich, Carrie Wittmer, Michelle D. Hendricks, Carolyn Lowe, Christiane Villescaz, Joseph S. Heilig, Carrie S. Dolman, Jason R. Clapper, Guibao Gu, Jonathan D. Roth, Jennifer Athanacio
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 305(7)
Shortcomings of previously reported preclinical models of nonalcoholic steatohepatitis (NASH) include inadequate methods used to induce disease and assess liver pathology. We have developed a dietary model of NASH displaying features observed clinica
Autor:
Barbara L. Roland, Guibao Gu, Joseph S. Heilig, Kevin Tomaselli, Carolyn Lowe, Carrie S. Dolman
Publikováno v:
The Journal of comparative neurology. 521(10)
Glucagon-like-peptide 1 (GLP-1) is expressed not only in gut endocrine cells, but also in cells in the caudal brainstem and taste buds. To better understand the functions of central GLP-1, GLP-1 expression was immunohistochemically profiled in normal
Autor:
Wenyuan Wu, Dorothy Markowitz, Charles D. Kaplan, Yunping Luo, Sung-Hyung Lee, Cheng Liu, Jörg Krueger, He Zhou, Ralph A. Reisfeld, Carrie S. Dolman, Rong Xiang
Publikováno v:
The Journal of clinical investigation. 116(8)
Tumor-associated macrophages (TAMs) are associated with tumor progression and metastasis. Here, we demonstrate for the first time that legumain, a member of the asparaginyl endopeptidase family functioning as a stress protein, overexpressed by TAMs,
Autor:
Rong Xiang, Andreas G. Niethammer, J. Michael Ruehlmann, Stephen D. Gillies, Yi Ba, Ralph A. Reisfeld, Carrie S. Dolman, F. James Primus
Publikováno v:
Vaccine. 20(3-4)
A DNA vaccine encoding human carcinoembryonic antigen (CEA) broke peripheral T-cell tolerance toward this tumor self-antigen expressed by Lewis lung carcinoma stably transduced with CEA in C57BL/6J mice transgenic for CEA. This vaccine, delivered by
Autor:
J. Michael Ruehlmann, Nicholas P. Restifo, Ralph A. Reisfeld, Willem W. Overwijk, Carrie S. Dolman, Ta Hsiang Chao, J. Lindsay Whitton, Fernando Rodriguez, Rong Xiang, Holger N. Lode
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 97(10)
We demonstrated that peripheral T cell tolerance toward murine melanoma self-antigens gp100 and TRP-2 can be broken by an autologous oral DNA vaccine containing the murine ubiquitin gene fused to minigenes encoding peptide epitopes gp10025–33and TR
Autor:
Trevaskis, James L., Griffin, Peter S., Wittmer, Carrie, Neuschwander-Tetri, Brent A., Brunt, Elizabeth M., Carrie S. Dolman, Carrie S., Erickson, Mary R., Napora, James, Parkes, David G., Roth, Jonathan D.
Publikováno v:
American Journal of Physiology: Gastrointestinal & Liver Physiology; Apr2012 Part2, Vol. 302 Issue 4, pG762-G772, 11p