Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Carrie R. Valentine"'
Autor:
Joseph G. Shaddock, Jessica M. Farrell, Robert R. Delongchamp, Vasily N. Dobrovolsky, Heather F. Rainey, Carrie R. Valentine
Publikováno v:
Mutagenesis. 23:383-397
A perceived disadvantage of transgenic rodent mutation assays is that spontaneous mutant frequencies are high compared to those of endogenous genes and may consequently reduce sensitivity to induced mutation. We have previously argued that unrepaired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a33e64a5498fd1f46cdfafe36d6d9d
https://doi.org/10.1093/mutage/gen026
https://doi.org/10.1093/mutage/gen026
Autor:
Jessica M. Farrell, Bruce S. Hass, Paul C. Howard, Heather F. Rainey, Carrie R. Valentine, Robert R. Delongchamp
Publikováno v:
Genes and Environment. 29:38-53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::372a1b0925420508539bbe4f99fd1b1f
https://doi.org/10.3123/jemsge.29.38
https://doi.org/10.3123/jemsge.29.38
Autor:
Jessica L. Raney, Joseph G. Shaddock, Carrie R. Valentine, Robert R. Delongchamp, Vasily N. Dobrovolsky
Publikováno v:
Environmental and Molecular Mutagenesis. 44:128-150
Single-burst analysis was applied to a forward assay for gene A mutation in splenic lymphocytes of phiX174 transgenic mice for the purpose of optimizing analytical parameters for identifying in vivo mutations. The effect of varying the cutoff value f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288e19b189ef8853b41a47eb6f825c00
https://doi.org/10.1002/em.20043
https://doi.org/10.1002/em.20043
Publikováno v:
Environmental and Molecular Mutagenesis. 42:258-273
Transgenic systems for measuring mammalian mutagenesis often use recoverable viral vectors. We hypothesize that mutations in these transgenic systems can arise from three different origins of DNA damage and replication errors and that these three ori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dace329ca0f9c17c035f0bf43c0bfd8
https://doi.org/10.1002/em.10195
https://doi.org/10.1002/em.10195
Autor:
Robert R. Delongchamp, Beverly Montgomery, Scott G. Miller, Bentley A. Fane, Heinrich V. Malling, Carrie R. Valentine
Publikováno v:
Environmental and Molecular Mutagenesis. 39:55-68
The sensitivity of in vivo transgenic mutation assays benefits from the sequencing of mutations, although the large number of possible mutations hinders high throughput sequencing. A forward mutational assay exists for ΦX174 that requires an altered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d5575e868abbec317d15726cfbb831
https://doi.org/10.1002/em.10043
https://doi.org/10.1002/em.10043
Publikováno v:
Environmental and Molecular Mutagenesis. 37:356-360
In mutation assays using transgenic mice, with recoverable vectors such as PhiX174 am3, cs70, mutations originate from two sources: (1) in vivo mutations, that is, mutations that were fixed in the mouse, or (2) ex vivo mutations, that is, mutations t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::541b9201ce754563c0fcbb76529d974b
https://doi.org/10.1002/em.1043
https://doi.org/10.1002/em.1043
Publikováno v:
Mutation Research/Mutation Research Genomics. 432:15-32
Exon skipping that accompanies exonic mutation might be caused by an effect of the mutation on pre-mRNA secondary structure. Previous attempts to associate predicted secondary structure of pre-mRNA with exon skipping have been hindered by either a sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54027540b7e468e5ca6e21edd5879e29
https://doi.org/10.1016/s1383-5726(99)00011-4
https://doi.org/10.1016/s1383-5726(99)00011-4
Autor:
Carrie R. Valentine
Publikováno v:
Mutation Research/Reviews in Mutation Research. 411:87-117
Some genes that contain premature nonsense codons express alternatively-spliced mRNA that has skipped the exon containing the nonsense codon. This paradoxical association of translation signals (nonsense codons) and RNA splicing has inspired numerous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1373355a0a8b9dfa45a4fdec66095d5
https://doi.org/10.1016/s1383-5742(98)00010-6
https://doi.org/10.1016/s1383-5742(98)00010-6
Publikováno v:
Plasmid. 32:222-227
The restriction enzyme and genetic map of the antibiotic-resistance region of plasmid pSa is related to Tn21 integrons by the insertion of 5.4 kb containing a chloramphenicol resistance gene (catII) and a 1.1-kb direct repeat. We report here the nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1516ecd00a639caf83e8494c8cdb05
https://doi.org/10.1006/plas.1994.1059
https://doi.org/10.1006/plas.1994.1059
Autor:
Heinrich V. Malling, Heather F. Rainey, Robert R. Delongchamp, Mason G. Pearce, Vasily N. Dobrovolsky, Carrie R. Valentine, Robert H. Heflich
Publikováno v:
Mutation research. 705(3)
The ΦX174 transgenic mouse was first developed as an in vivo Ames test, detecting base pair substitution (bps) at a single bp in a reversion assay. A forward mutational assay was also developed, which is a gain of function assay that also detects bp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d67ccc0d6d384bbb77f796b11845fe3
https://pubmed.ncbi.nlm.nih.gov/20637298
https://pubmed.ncbi.nlm.nih.gov/20637298