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Publikováno v:
Cytokine. 156:155897
The IL-36 family of cytokines includes three pro-inflammatory agonists (IL-36α, IL-36β, and IL-36γ) and a receptor antagonist (IL-36Ra), which bind and signal through a heterodimeric receptor composed of IL-36R and the IL-1R accessory protein (IL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab313c850423628ed6a488dcfcfcc176
https://doi.org/10.1016/j.cyto.2022.155897
https://doi.org/10.1016/j.cyto.2022.155897
Autor:
Carrie N. Arnold
Publikováno v:
Proceedings of the National Academy of Sciences. 115:3988-3991
Researchers are learning more about the baffling, deadly condition. Treatments are elusive, but one thing’s for certain: timing is everything . At first, it looked like the flu. So doctors in Tolima, Colombia, advised Olga Pena’s 70-year-old fath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::484ebe5eead6be85df49461d47f031ed
https://doi.org/10.1073/pnas.1803551115
https://doi.org/10.1073/pnas.1803551115
Publikováno v:
Immunity. 51:209-211
The interplay between intestinal epithelial barrier function, the intestinal microbiota, and cytokine signaling in the pathogenesis of inflammatory bowel disease is not completely understood. In this issue of Immunity, Eftychi et al. examined the cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61bcccd4b2a54698ef76a4b8e1e27b4c
https://doi.org/10.1016/j.immuni.2019.07.008
https://doi.org/10.1016/j.immuni.2019.07.008
Autor:
Michael J Barnes, Philippe Krebs, Nathaniel Harris, Celine Eidenschenk, Rosana Gonzalez-Quintial, Carrie N Arnold, Karine Crozat, Sosathya Sovath, Eva Marie Moresco, Argyrios N Theofilopoulos, Bruce Beutler, Kasper Hoebe
Publikováno v:
PLoS Biology, Vol 7, Iss 3, p e51 (2009)
Regulatory T (T(reg)) cells expressing forkhead box P3 (Foxp3) arise during thymic selection among thymocytes with modestly self-reactive T cell receptors. In vitro studies suggest Foxp3 can also be induced among peripheral CD4(+) T cells in a cytoki
Externí odkaz:
https://doaj.org/article/81de9018dcbd4a3388ceff1a8b7757de
Autor:
Carrie N. Arnold
Publikováno v:
Proceedings of the National Academy of Sciences. 114:10509-10511
After infecting the bacterium Bordetella bronchiseptica (shown here) with a bacteriophage, researchers stumbled on findings that led them to diversity-generating retroelements, part of a potentially important microbial mechanism for generating a dive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::812169ddc596dfafe3b0b86c4cdec010
https://doi.org/10.1073/pnas.1714687114
https://doi.org/10.1073/pnas.1714687114
Autor:
Carola G. Vinuesa, Edward M. Bertram, Charis E Teh, Keisuke Horikawa, Carrie N. Arnold, Anselm Enders, Bruce Beutler, Christopher C. Goodnow, Edyta M. Kucharska
Publikováno v:
Genes and immunity
To identify rate-limiting steps in T cell-independent type 2 antibody production against polysaccharide antigens, we performed a genome-wide screen by immunizing several hundred pedigrees of C57BL/6 mice segregating N-ethyl-N-nitrosurea-induced mis-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9d0173460f3e3bf6499517f3aab1d5
https://doi.org/10.1038/gene.2013.11
https://doi.org/10.1038/gene.2013.11
Autor:
Elaine Pirie, Bruce Beutler, David Nemazee, Philippe Krebs, Christoph Huber, Nora G. Smart, Kevin Khovananth, Gunilla B. Karlsson Hedestam, Yu Xia, Michael Berger, Celine Eidenschenk, Gerald M. McInerney, Owen M. Siggs, Carrie N. Arnold
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Null alleles of the gene encoding NEMO (NF-κB essential modulator) are lethal in hemizygous mice and men, whereas hypomorphic alleles typically cause a syndrome of immune deficiency and ectodermal dysplasia. Here we describe an allele of Ikbkg in mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e369d1dd81e1b7daa09ce8dd8244008
https://ora.ox.ac.uk/objects/uuid:06c08181-70d5-48dd-aa47-844e2ab8ef77
https://ora.ox.ac.uk/objects/uuid:06c08181-70d5-48dd-aa47-844e2ab8ef77
Autor:
Carrie N. Arnold, Bruce Beutler, Julian M. Stark, Gabriel K. Pedersen, Sharesta Khoenkhoen, Gunilla B. Karlsson Hedestam, Monika Adori
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Frontiers in Immunology
Frontiers in Immunology
Mice deficient in central components of classical NF-κB signaling have low levels of circulating natural IgM antibodies and fail to respond to immunization with T-independent type 2 (TI-2) antigens. A plausible explanation for these defects is the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce7679d74f16758919def52052d5eda
https://doi.org/10.3389/fimmu.2016.00065
https://doi.org/10.3389/fimmu.2016.00065
Autor:
David Nemazee, Pei Lin, Owen M. Siggs, Bruce Beutler, Elaine Pirie, Christoph Huber, Yu Xia, Carrie N. Arnold
Publikováno v:
Nature immunology
B lymphopoiesis begins in the fetal liver, switching after birth to the bone marrow, where it persists for life. The unique developmental outcomes of each phase are well documented, yet their molecular requirements are not. Here we describe two allel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5f3b044b8ee2bf254a0bbe8c2167c0
https://doi.org/10.1038/ni.2012
https://doi.org/10.1038/ni.2012