Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Carrie McCracken"'
Autor:
Povilas Kavaliauskas, Yiyou Gu, Naushaba Hasin, Karen T. Graf, Abdullah Alqarihi, Amol C. Shetty, Carrie McCracken, Thomas J. Walsh, Ashraf S. Ibrahim, Vincent M. Bruno
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract During pulmonary mucormycosis, inhaled sporangiospores adhere to, germinate, and invade airway epithelial cells to establish infection. We provide evidence that HIF1α plays dual roles in airway epithelial cells during Mucorales infection. W
Externí odkaz:
https://doaj.org/article/759c656495cf48bf9e8817fa4689eea1
Autor:
Amol Carl Shetty, John Sivinski, Jessica Cornell, Carrie McCracken, Lisa Sadzewicz, Anup Mahurkar, Xing-Qun Wang, Luana Colloca, Weihong Lin, Nageswara Pilli, Maureen A. Kane, Chamindi Seneviratne
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Molecular responses to alcohol consumption are dynamic, context-dependent, and arise from a complex interplay of biological and external factors. While many have studied genetic risk associated with drinking patterns, comprehensive studies i
Externí odkaz:
https://doaj.org/article/46f8d1b03a29479b885e12f242d0224f
Autor:
Jeffrey M. Rybak, Jinhong Xie, Adela Martin-Vicente, Xabier Guruceaga, Harrison I. Thorn, Ashley V. Nywening, Wenbo Ge, Ana C. O. Souza, Amol C. Shetty, Carrie McCracken, Vincent M. Bruno, Josie E. Parker, Steven L. Kelly, Hannah M. Snell, Christina A. Cuomo, P. David Rogers, Jarrod R. Fortwendel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Triazole antifungals function as ergosterol biosynthesis inhibitors and are frontline therapy for invasive fungal infections, such as invasive aspergillosis. The primary mechanism of action of triazoles is through the specific inhibition of
Externí odkaz:
https://doaj.org/article/f05294528fb640d8a22b184dae7ef4b2
Autor:
Taissa Vila, Eric F. Kong, Daniel Montelongo-Jauregui, Patrick Van Dijck, Amol C. Shetty, Carrie McCracken, Vincent M. Bruno, Mary Ann Jabra-Rizk
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 835-851 (2021)
Biofilm-associated polymicrobial infections tend to be challenging to treat. Candida albicans and Staphylococcus aureus are leading pathogens due to their ability to form biofilms on medical devices. However, the therapeutic implications of their int
Externí odkaz:
https://doaj.org/article/d87298cb93ee44fe958c2e0d3cbad180
Autor:
Chamindi Seneviratne, Amol Carl Shetty, Xinyan Geng, Carrie McCracken, Jessica Cornell, Kristin Mullins, Feng Jiang, Sanford Stass
Publikováno v:
Diagnostics, Vol 12, Iss 12, p 2897 (2022)
Lung cancers are the leading cause of cancer-related deaths worldwide. Studies have shown that non-small cell lung cancer (NSCLC), which constitutes the majority of lung cancers, is significantly more responsive to early-stage interventions. However,
Externí odkaz:
https://doaj.org/article/21416e589e734970955f8eb459b2d38e
Autor:
Jessica Saul-McBeth, John Dillon, Aaron Lee, Dylan Launder, Jacqueline M. Kratch, Eanas Abutaha, Alexandria A. Williamson, Allen G. Schroering, Grace Michalski, Priosmita Biswas, Samuel R. Conti, Amol C. Shetty, Carrie McCracken, Vincent M. Bruno, E. Ishmael Parsai, Heather R. Conti
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Oral mucositis (OM) is a treatment-limiting adverse side effect of radiation and chemotherapy. Approximately 80% of patients undergoing radiotherapy (RT) for head and neck cancers (HNC) develop OM, representing a major unmet medical condition. Our un
Externí odkaz:
https://doaj.org/article/7130fdda36ae4b158f008da3601ae03e
Autor:
Taissa Vila, Eric F. Kong, Ahmed Ibrahim, Kurt Piepenbrink, Amol C. Shetty, Carrie McCracken, Vincent Bruno, Mary Ann Jabra-Rizk
Publikováno v:
Virulence, Vol 10, Iss 1, Pp 625-642 (2019)
Microbial species utilize secreted-signaling molecules to coordinate their behavior. Our previous investigations demonstrated a key role for the Candida albicans-secreted quorum-sensing molecule farnesol in modulating Staphylococcus aureus response t
Externí odkaz:
https://doaj.org/article/62eba5f3f1bd4da889bfe04dba487f81
Autor:
Sebastian Wurster, Alexander M. Tatara, Nathaniel D. Albert, Ashraf S. Ibrahim, Joseph Heitman, Soo Chan Lee, Amol C. Shetty, Carrie McCracken, Karen T. Graf, Antonios G. Mikos, Vincent M. Bruno, Dimitrios P. Kontoyiannis
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Trauma-related necrotizing myocutaneous mucormycosis (NMM) has a high morbidity and mortality in victims of combat-related injuries, geometeorological disasters, and severe burns. Inspired by the observation that several recent clusters of N
Externí odkaz:
https://doaj.org/article/1d82ac74355b42f0895c16fb72c03309
Autor:
Angeliki M. Andrianaki, Irene Kyrmizi, Kalliopi Thanopoulou, Clara Baldin, Elias Drakos, Sameh S. M. Soliman, Amol C. Shetty, Carrie McCracken, Tonia Akoumianaki, Kostas Stylianou, Petros Ioannou, Charalampos Pontikoglou, Helen A. Papadaki, Maria Tzardi, Valerie Belle, Emilien Etienne, Anne Beauvais, George Samonis, Dimitrios P. Kontoyiannis, Evangelos Andreakos, Vincent M. Bruno, Ashraf S. Ibrahim, Georgios Chamilos
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Mucormycosis is a life-threatening respiratory fungal infection that typically occurs in patients with abnormalities in iron metabolism. Here the authors show that iron restriction inside the phagosome of macrophages is an essential component of the
Externí odkaz:
https://doaj.org/article/929e08b851964a52b6dd9b6ff495bee8
Autor:
Susan G Dorsey, Cynthia L Renn, Mari Griffioen, Cameron B Lassiter, Shijun Zhu, Heather Huot-Creasy, Carrie McCracken, Anup Mahurkar, Amol C Shetty, Colleen K Jackson-Cook, Hyungsuk Kim, Wendy A Henderson, Leorey Saligan, Jessica Gill, Luana Colloca, Debra E Lyon, Angela R Starkweather
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216539 (2019)
The mechanisms underlying the transition from acute to chronic pain remain unclear. Here, we sought to characterize the transcriptome associated with chronic low back pain as well as the transcriptome of the transition from acute to chronic low back
Externí odkaz:
https://doaj.org/article/bc47f946848d49b79ba34b1dbb87f23a