Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Carrie M Wilmot"'
Autor:
Bryan J Jones, Robert L Evans, Nathan J Mylrea, Debayan Chaudhury, Christine Luo, Bo Guan, Colin T Pierce, Wendy R Gordon, Carrie M Wilmot, Romas J Kazlauskas
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0235341 (2020)
Hydroxynitrile lyases (HNL's) belonging to the α/β-hydrolase-fold superfamily evolved from esterases approximately 100 million years ago. Reconstruction of an ancestral hydroxynitrile lyase in the α/β-hydrolase fold superfamily yielded a catalyti
Externí odkaz:
https://doaj.org/article/1032b638bceb4ed6a0096543bc797ca2
Autor:
Merlin Bresinsky, Jessica M. Strasser, Bernadette Vallaster, Peng Liu, William M. McCue, Jessica Fuller, Alexander Hubmann, Gurpreet Singh, Kathryn M. Nelson, Matthew E. Cuellar, Carrie M. Wilmot, Barry C. Finzel, Karen H. Ashe, Michael A. Walters, Steffen Pockes
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Alzheimer’s disease (AD) was first described by Alois Alzheimer over 100 years ago, but there is still no overarching theory that can explain its cause in detail. There are also no effective therapies to treat either the cause or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d23dbfa9d69eedac74f0ee60beb7c20
https://doi.org/10.1021/acsptsci.1c00251
https://doi.org/10.1021/acsptsci.1c00251
Autor:
Peng Liu, Miranda N. Reed, Linda A. Kotilinek, Marianne K.O. Grant, Colleen L. Forster, Wei Qiang, Samantha L. Shapiro, John H. Reichl, Angie C.A. Chiang, Joanna L. Jankowsky, Carrie M. Wilmot, James P. Cleary, Kathleen R. Zahs, Karen H. Ashe
Publikováno v:
Cell Reports, Vol 11, Iss 11, Pp 1760-1771 (2015)
The accumulation of amyloid-β (Aβ) as amyloid fibrils and toxic oligomers is an important step in the development of Alzheimer’s disease (AD). However, there are numerous potentially toxic oligomers and little is known about their neurological ef
Externí odkaz:
https://doaj.org/article/ed7d1c4523f74c97baa11c1bae853b85
Autor:
Michael J. Maroney, Chao Li, Carrie M. Wilmot, Joseph W. Vavra, Carolyn E. Carr, Hsin-Ting Huang
Publikováno v:
Acta Crystallogr F Struct Biol Commun
RcnR is a transcription factor that regulates the homeostasis of cobalt and nickel in bacterial cells. Escherichia coli RcnR was crystallized with DNA that encompasses the DNA-binding site. X-ray diffraction data were collected to 2.9 Å resolution.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c945d403afc94ce5c88f3c216cf5d6d
https://europepmc.org/articles/PMC6957110/
https://europepmc.org/articles/PMC6957110/
Autor:
Carrie M. Wilmot, Matthew R. Jensen, Morgan A. Esler, Fatuma A. Mohamed, Lawrence P. Wackett, James K. Christenson, Brandon R. Goblirsch
Publikováno v:
FEBS Letters. 592:987-998
Renewable production of hydrocarbons is being pursued as a petroleum-independent source of commodity chemicals and replacement for biofuels. The bacterial biosynthesis of long-chain olefins represents one such platform. The process is initiated by Ol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707c5fd6d59104f30b6c4e29d2b7a747
https://doi.org/10.1002/1873-3468.13004
https://doi.org/10.1002/1873-3468.13004
Autor:
James K. Christenson, Brandon R. Goblirsch, Lawrence P. Wackett, Matthew R. Jensen, Morgan A. Esler, Carrie M. Wilmot, Fatuma A. Mohamed
Publikováno v:
Biochemical Journal. 474:3871-3886
In the interest of decreasing dependence on fossil fuels, microbial hydrocarbon biosynthesis pathways are being studied for renewable, tailored production of specialty chemicals and biofuels. One candidate is long-chain olefin biosynthesis, a widespr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad52383a2760b3fba0f7633062720eab
https://doi.org/10.1042/bcj20170642
https://doi.org/10.1042/bcj20170642
Publikováno v:
Biochemistry, vol 56, iss 21
Biosynthesis of the ribosomally synthesized and post-translationally modified peptide (RiPP), pyrroloquinoline quinone (PQQ), is initiated when the precursor peptide, PqqA, is recognized and bound by the RiPP precursor peptide recognition element (RR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e1ddce53fd84b6803cf874ae1aae3e
https://doi.org/10.1021/acs.biochem.7b00247
https://doi.org/10.1021/acs.biochem.7b00247
Autor:
Carrie M. Wilmot, Lawrence P. Wackett, Jack E. Richman, Matthew R. Jensen, Jennifer Y. Neufeld, James K. Christenson
Publikováno v:
Biochemistry. 56:348-351
The first β-lactone synthetase enzyme is reported, creating an unexpected link between the biosynthesis of olefinic hydrocarbons and highly functionalized natural products. The enzyme OleC, involved in the microbial biosynthesis of long-chain olefin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82da22b80c86e998e7125491481ba7f0
https://doi.org/10.1021/acs.biochem.6b01199
https://doi.org/10.1021/acs.biochem.6b01199
Autor:
Carrie M. Wilmot, Fatuma A. Mohamed, Brandon R. Goblirsch, Matthew R. Jensen, Lawrence P. Wackett
Publikováno v:
Journal of Biological Chemistry. 291:26698-26706
Phylogenetically diverse microbes that produce long chain, olefinic hydrocarbons have received much attention as possible sources of renewable energy biocatalysts. One enzyme that is critical for this process is OleA, a thiolase superfamily enzyme th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b135aa65dad1258c71e11dc9c02fae2
https://doi.org/10.1074/jbc.m116.760892
https://doi.org/10.1074/jbc.m116.760892
Autor:
Carrie M. Wilmot, Eric M. Koehn, Judith P. Klinman, Robert L. Evans, Tara Armand, Xiongying Tu, John A. Latham, Anthony T. Iavarone
Publikováno v:
Journal of the American Chemical Society. 141(10)
Understanding the biosynthesis of cofactors is fundamental to the life sciences, yet to date a few important pathways remain unresolved. One example is the redox cofactor pyrroloquinoline quinone (PQQ), which is critical for C1 metabolism in many mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d451dcd75c93a1e56620bbdddf766210
https://pubmed.ncbi.nlm.nih.gov/30811189
https://pubmed.ncbi.nlm.nih.gov/30811189