Zobrazeno 1 - 5 of 5 pro vyhledávání: '"Carrie Lomelino"'
1
Akademický článek
The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII
Autor: Alessandro Bonardi, Silvia Bua, Jacob Combs, Carrie Lomelino, Jacob Andring, Sameh Mohamed Osman, Alessandra Toti, Lorenzo Di Cesare Mannelli, Paola Gratteri, Carla Ghelardini, Robert McKenna, Alessio Nocentini, Claudiu T. Supuran
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 930-939 (2022)
Human (h) carbonic anhydrase (CAs, EC 4.2.1.1) isoforms IX and XII were recently confirmed as anticancer targets against solid hypoxic tumours. The “three-tails approach” has been proposed as an extension of the forerunner “tail” and “dual-
Externí odkaz: https://doaj.org/article/412ee4b931a947cf9e44dab830b6bc29
Zobrazit plný text záznamu
3
One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes
Autor: Gioele Vannozzi, Daniela Vullo, Andrea Angeli, Marta Ferraroni, Jacob Combs, Carrie Lomelino, Jacob Andring, Robert Mckenna, Gianluca Bartolucci, Marco Pallecchi, Laura Lucarini, Silvia Sgambellone, Emanuela Masini, Fabrizio Carta, Claudiu T. Supuran
Publikováno v: Journal of medicinal chemistry. 65(1)
We report a one-pot procedure for the synthesis of asymmetrical ureido-containing benzenesulfonamides based on in situ generation of the corresponding isocyanatobenezenesulfonamide species, which were trapped with the appropriate amines. A library of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114fa27d245f828e1b99acd9cb802119
https://pubmed.ncbi.nlm.nih.gov/34958217
Zobrazit plný text záznamu
4
Development of a novel class of selective human carbonic anhydrase IX inhibitors containing a trifluorohydroxy propanone pharmacophore
Autor: Nicolino Pala, Roberta Cadoni, Carrie Lomelino, Brian P. Mahon, Robert McKenna, Roberto Dallocchio, Alessandro Dessì, Mauro Carcelli, Viengsavanh Pimxayvong, Claudia Crosio, Rino Weber, Daniela Vullo, Claudiu Supuran, Mario Sechi
Publikováno v: 4st Satellite Meeting on Carbonic Anhydrase, Parma, 14-17/11/2019
info:cnr-pdr/source/autori:Nicolino Pala, Roberta Cadoni, Carrie Lomelino, Brian P. Mahon, Robert McKenna, Roberto Dallocchio, Alessandro Dessì, Mauro Carcelli, Viengsavanh Pimxayvong, Claudia Crosio, Rino Weber, Daniela Vullo, Claudiu Supuran, Mario Sechi/congresso_nome:4st Satellite Meeting on Carbonic Anhydrase/congresso_luogo:Parma/congresso_data:14-17%2F11%2F2019/anno:2019/pagina_da:/pagina_a:/intervallo_pagine
Carbonic anhydrases (CAs) are emerging as potential biological targets for cancer therapy. In particular, hCA IX isoform has been found to be expressed in a wide variety of malignancies and appear to be tightly regulated by micro-environmental hypoxi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::43c3340500f9bd67a50f6ba6662982ed
http://www.cnr.it/prodotto/i/409899
Zobrazit plný text záznamu
5
Abstract 1758: Splicing component ISY1 interacts with APE1 and regulates base excision repair
Autor: Aruna Jaiswal, Elizabeth Williamson, Bhavita Patel, Gayathri Srinivasan, Kimi Kong, Carrie Lomelino, Satya Narayan, Robert Hromas
Publikováno v: Cancer Research. 79:1758-1758
Cellular genome is continuously challenged by endogenous and exogenous DNA damaging agents. In the genome, base modifications are the most common form of DNA damage. Base excision DNA repair (BER) is the most important pathway for the removal of oxid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b2b8f3ed58212233d0c526c97285fa1
https://doi.org/10.1158/1538-7445.am2019-1758
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje