Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Carrie L. Moland"'
Autor:
Varsha G. Desai, Taewon Lee, Carrie L. Moland, William S. Branham, Roberta A. Mittelstaedt, Sherry M. Lewis, Julian E. A. Leakey, James C. Fuscoe
Publikováno v:
AIDS Research and Treatment, Vol 2012 (2012)
The effects of 12-week exposure to zidovudine (AZT) at 400, 500, and 600 mg/kg/d were examined on expression of 542 mitochondria-related genes and mitochondrial DNA (mtDNA) copy number in the liver of male and female B6C3F1 mice to understand mitocho
Externí odkaz:
https://doaj.org/article/de3287a29a3c45bfb09c952ecd52aa43
Autor:
Varsha G. Desai, Ana Azevedo‐Pouly, Vikrant Vijay, Bounleut Phanavanh, Carrie L. Moland, Tao Han, Javier Revollo, Baikuntha Aryal, V. Ashutosh Rao, James C. Fuscoe
Publikováno v:
Journal of applied toxicology : JATREFERENCES.
Preclinical and clinical findings suggest sexual dimorphism in cardiotoxicity induced by a chemotherapeutic drug, doxorubicin (DOX). However, molecular alterations leading to sex-related differential vulnerability of heart to DOX toxicity are not ful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0bd1f0db176887309be708f87aa962
https://pubmed.ncbi.nlm.nih.gov/36227756
https://pubmed.ncbi.nlm.nih.gov/36227756
Autor:
Varsha G. Desai, Vikrant Vijay, Taewon Lee, Tao Han, Carrie L. Moland, Bounleut Phanavanh, Eugene H. Herman, Kimo Stine, James C. Fuscoe
Publikováno v:
Journal of applied toxicology : JATREFERENCES. 42(9)
Cardiotoxicity is a serious adverse effect of an anticancer drug, doxorubicin (DOX), which can occur within a year or decades after completion of therapy. The present study was designed to address a knowledge gap concerning a lack of circulating biom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f95bc67f2b3c49f1c203c200798e08
https://pubmed.ncbi.nlm.nih.gov/35199358
https://pubmed.ncbi.nlm.nih.gov/35199358
Autor:
Varsha G. Desai, Taewon Lee, Carrie L. Moland, Kelly Davis, Vikrant Vijay, Kimo C. Stine, James C. Fuscoe, Tao Han, Bounleut Phanavanh, Levan Muskhelishvili
Publikováno v:
Journal of applied toxicology : JATREFERENCES. 42(5)
Subclinical cardiotoxicity at low total cumulative doxorubicin (DOX) doses can manifest into cardiomyopathy in long-term cancer survivors. However, the underlying mechanisms are poorly understood. In male B6C3F1 mice, assessment of cardiac function b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66081519ec4eb74d375c1461eb6621d7
https://pubmed.ncbi.nlm.nih.gov/34668590
https://pubmed.ncbi.nlm.nih.gov/34668590
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75305 (2013)
Age is a predisposing condition for susceptibility to chronic kidney disease and progression as well as acute kidney injury that may arise due to the adverse effects of some drugs. Age-related differences in kidney biology, therefore, are a key conce
Externí odkaz:
https://doaj.org/article/0b9472c323f54218b1a985a04e0c7179
Autor:
Taewon Lee, Levan Muskhelishvili, James C. Fuscoe, Eugene H. Herman, Carrie L. Moland, Susan Kerr, Kelly Davis, G. Ronald Jenkins, Vikrant Vijay, Varsha G. Desai, Sherry M. Lewis
Publikováno v:
Toxicology and Applied Pharmacology. 310:159-174
Sex is a risk factor for development of cardiotoxicity, induced by the anti-cancer drug, doxorubicin (DOX), in humans. To explore potential mechanisms underlying differential susceptibility to DOX between sexes, 8-week old male and female B6C3F1 mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54a36b2a24fb274f5379770c8446982a
https://doi.org/10.1016/j.taap.2016.09.012
https://doi.org/10.1016/j.taap.2016.09.012
Autor:
Varsha G, Desai, Taewon, Lee, Carrie L, Moland, Vikrant, Vijay, Tao, Han, Sherry M, Lewis, Eugene H, Herman, James C, Fuscoe
Publikováno v:
Toxicology and applied pharmacology. 363
Cardiotoxicity is a serious adverse effect of doxorubicin (DOX) treatment in cancer patients. Currently, there is a lack of sensitive biomarkers to predict the risk of DOX-induced cardiotoxicity. Using SOMAmer-based proteomic technology, 1129 protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f5582af9862da1f7860ced0b2a5c8ae
https://pubmed.ncbi.nlm.nih.gov/30517846
https://pubmed.ncbi.nlm.nih.gov/30517846
Autor:
Elliot T. Rosen, V. Ashutosh Rao, Kaytee L. Pokrzywinski, Baikuntha Aryal, Carrie L. Moland, Jennifer S. Dickey, Yanira Gonzalez, Leena M. Chehab, Vikrant Vijay, Steven R. Mog, Varsha G. Desai
Publikováno v:
Cancer Chemotherapy and Pharmacology. 76:447-459
Chemotherapy with doxorubicin (Dox) causes dose-limiting cardiotoxicity. We investigated the role that gender has on cardiosensitivity to Dox treatment by evaluating reproductive hormone levels in male, castrated male (c-male), female and ovariectomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedee363a40fbba38ca7178211a6fb23
https://doi.org/10.1007/s00280-015-2786-8
https://doi.org/10.1007/s00280-015-2786-8
Publikováno v:
Biology of Sex Differences
Background Physiological factors such as age and sex have been shown to be risk factors for adverse effects in the liver, including liver diseases and drug-induced liver injury. Previously, we have reported age- and sex-related significant difference
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fba7527ea75cbfe507e52543039a63b
https://doi.org/10.1186/s13293-017-0127-9
https://doi.org/10.1186/s13293-017-0127-9
Autor:
Hong Fang, Carrie L. Moland, Daniel M. Sheehan, Stacey L. Dial, Hui Wen Ng, Roger Perkins, Weida Tong, William S. Branham, Huixiao Hong
Publikováno v:
Toxicological Sciences. 143:333-348
One endocrine disruption mechanism is through binding to nuclear receptors such as the androgen receptor (AR) and estrogen receptor (ER) in target cells. The concentration of a chemical in serum is important for its entry into the target cells to bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c428df8f78020439df96f0398741c087
https://doi.org/10.1093/toxsci/kfu231
https://doi.org/10.1093/toxsci/kfu231