Partial mGlu5 Negative Allosteric Modulator M-5MPEP Demonstrates Antidepressant-Like Effects on Sleep Without Affecting Cognition or Quantitative EEG

Autor: Kimberly M. Holter, Alex D. Lekander, Christina M. LaValley, Elizabeth G. Bedingham, Bethany E. Pierce, L. Paul Sands, Craig W. Lindsley, Carrie K. Jones, Robert W. Gould

Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)

Selective negative allosteric modulators (NAMs) targeting the metabotropic glutamate receptor subtype 5 (mGlu5) demonstrate anxiolytic-like and antidepressant-like effects yet concern regarding adverse effect liability remains. Functional coupling of

Externí odkaz: https://doaj.org/article/0a0ae44e0f6442668ba0e76ba53e03d1

M 1 -selective muscarinic allosteric modulation enhances cognitive flexibility and effective salience in nonhuman primates

Autor: Seyed A. Hassani, Adam Neumann, Jason Russell, Carrie K. Jones, Thilo Womelsdorf

Publikováno v: Proceedings of the National Academy of Sciences. 120

Acetylcholine (ACh) in cortical neural circuits mediates how selective attention is sustained in the presence of distractors and how flexible cognition adjusts to changing task demands. The cognitive domains of attention and cognitive flexibility mig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77d78203c096718224bb93de557cb601
https://doi.org/10.1073/pnas.2216792120

Contributors

Autor: Daniela Accorsi–Mendonça, David J. Adams, Andrew M. Allen, Marlies Alvarenga, Jeffrey L. Ardell, Amy C. Arnold, Jesse L. Ashton, Mark B. Badrov, Brennan A. Ballantyne, Emma N. Bardsley, Soledad Barez-Lopez, Susan M. Barman, Carolyn J. Barrett, Deborah Bauer, Christopher Bell, Alona Ben-Tal, Eduardo E. Benarroch, Italo Biaggioni, Katharina Brandl, Virginia L. Brooks, Amy E. Brown, Kirsteen N. Browning, Meredith Bryarly, Livia L. Camargo, Michael Camilleri, Preston J. Campbell, Marc G. Caron, Jason R. Carter, Mark W. Chapleau, Nisha Charkoudian, Gisela Chelimsky, Thomas C. Chelimsky, Pitcha Chompoopong, Victoria E. Claydon, Gilles Clément, Victor A. Convertino, Elizabeth A. Coon, Pietro Cortelli, Stephen N. Davis, André Diedrich, Donald J. DiPette, Debra I. Diz, Marcus J. Drake, Graeme Eisenhofer, Florent Elefteriou, Fernando Elijovich, Eva-Maria Elmenhorst, Brett A. English, Murray Esler, Rosemary Esler, Paul J. Fadel, John M. Fahrenholz, Alessandra Fanciulli, John Y. Fang, Robert D. Fealey, Nathanne S. Ferreira, Renato Filogonio, Gregory D. Fink, James P. Fisher, John S. Floras, Samuel J. Fountain, Qi Fu, Marat Fudim, Raffaello Furlan, Alfredo Gamboa, Emily M. Garland, Christopher H. Gibbons, Andrew Giritharan, David S. Goldstein, Diego A. Golombék, Elise P. Gomez-Sanchez, Celso E. Gomez-Sanchez, Robert M. Graham, Guido Grassi, Ian M. Greenlund, Blair P. Grubb, Alla Guekht, Sarah-Jane Guild, Ling Guo, Vsevolod V. Gurevich, Ralf Habermann, Joseph Hadaya, Maureen K. Hahn, Peter Hanna, Luke A. Henderson, Neil Herring, Max J. Hilz, Peter Hunter, Keith Hyland, Lauren A. Hyland, Edwin Kerry Jackson, Giris Jacob, Wilfrid Jänig, Nina Japundžić-Žigon, Carrie K. Jones, Karen M. Joos, Jens Jordan, William Joyce, Xenia Kaidonis, Horacio Kaufmann, David Kaye, Abdul Mannan Khan Minhas, Joyce S. Kim, Takeya Kitta, David D. Kline, Thomas Konecny, Natalie J. Koons, Ambrish Kumar, Cheryl L. Laffer, Andre H. Lagrange, Nora Laiken, Gavin Lambert, Elisabeth Lambert, Guillaume Lamotte, Jacques W.M. Lenders, Benjamin D. Levine, Fabian Leys, Ulrich Limper, Mabelle Lin, Eduardo Listik, Reid Longmuir, David A. Low, Phillip A. Low, James M. Luther, Vaughan G. Macefield, Benedito H. Machado, Maria-Bernadette Madel, Davide Martelli, Christopher J. Mathias, Michelle L. Mauermann, Robin M. McAllen, Fiona D. McBryde, Andrew McKeon, Michael J. McKinley, Clément Menuet, Douglas F. Milam, Marion C. Mohl, Johanna M. Montgomery, Davi J.A. Moraes, Shaun F. Morrison, David Murphy, Charles D. Nichols, Piotr Niewiński, Lucy Norcliffe-Kaufmann, Luis E. Okamoto, Mahyar Osanlouy, John W. Osborn, Viktor Oubaid, Jose-Alberto Palma, Christina Pamporaki, Brian A. Parsons, David J. Paterson, Julian F.R. Paton, Amanda C. Peltier, Umberto Pensato, Sean M. Peterson, Fenna T. Phibbs, Giulia Pierangeli, Jay D. Potts, Alejandro A. Rabinstein, Mohan K. Raizada, Satish R. Raj, Casey M. Rand, Heinz Reichmann, Calum Robertson, Rose Marie Robertson, Michael B. Robinson, Mohammed Ruzieh, Paola Sandroni, Takayuki Sato, Ernesto L. Schiffrin, Markus Schlaich, Ronald Schondorf, Harold D. Schultz, Michael M. Scott, Gino Seravalle, John R. Shannon, Abu Baker Sheikh, Cyndya A. Shibao, Kalyanam Shivkumar, Kamal Shouman, Timo Siepmann, Wolfgang Singer, Elias Soltani, Virend Somers, Aadhavi Sridharan, Nadia Stefanova, Julian Stewart, Lauren E. Stiles, Kenji Sunagawa, Jens Tank, Roland D. Thijs, Jakub Tomek, Rhian M. Touyz, Jennifer A. Tracy, R. Alberto Travagli, Bradley J. Undem, Nikhil Urs, Steven Vernino, Lauro C. Vianna, Daniel E. Vigo, Margaret A. Vizzard, Amr Wahba, Waqar Waheed, Han-Jun Wang, Tobias Wang, Qin Wang, Ruihao Wang, Debra E. Weese-Mayer, Gregor K. Wenning, Wouter Wieling, Kevin W. Williams, Ursula H. Winzer-Serhan, Scott Wood, Kai Lee Yap, Naoki Yoshimura, Kirill A. Zavalin, Dmitry Zhuravlev, Daniel B. Zoccal, Jasenka Zubcevic

Publikováno v: Primer on the Autonomic Nervous System ISBN: 9780323854924

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bafd1601fa1262b19bc5727a98b1d87
https://doi.org/10.1016/b978-0-323-85492-4.01002-4

The M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) VU0453595 and M4 PAM VU0467154 Normalize Sleep‐Wake Architecture Deficits in Aged Mice

Autor: Jason K Russell, Michael Bubser, Shalonda Ingram, Paul A Newhouse, Craig W Lindsley, Carrie K Jones

Publikováno v: Alzheimer's & Dementia. 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8ec32c4fd0c065803c8a87306125252
https://doi.org/10.1002/alz.067229

M 1 muscarinic acetylcholine receptor positive allosteric modulators do not disrupt sleep in aged cynomolgus macaques

Autor: Robert W Gould, Alex D Lekander, C Ryan Curry, Nina Lavalley, Jason K Russell, Paul A Newhouse, Michael A Nader, Carrie K Jones

Publikováno v: Alzheimer's & Dementia. 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7b3403ad4e411e2dd36c3c9b2092bce
https://doi.org/10.1002/alz.067660