Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice

Autor: Calvin Simerly, Emily Robertson, Caleb Harrison, Sydney Ward, Charlize George, Jasmine Deleon, Carrie Hartnett, Gerald Schatten

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)

Abstract Transforming acidic acid coiled-coil protein 3 (TACC3) and cytoskeleton associated protein 5 (cKAP5; or colonic hepatic tumor overexpressed gene, chTOG) are vital for spindle assembly and stabilization initiated through TACC3 Aurora-A kinase

Externí odkaz: https://doaj.org/article/ae179d09c22641ce9f1bce1db1bdc8d0

Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells

Autor: Xiong Zhang, Calvin Simerly, Carrie Hartnett, Gerald Schatten, Thomas E. Smithgall

Publikováno v: Stem Cell Research, Vol 13, Iss 3, Pp 379-389 (2014)

Embryonic stem (ES) cells are characterized by pluripotency, defined as the developmental potential to generate cell lineages derived from all three primary germ layers. In the past decade, great progress has been made on the cell culture conditions,

Externí odkaz: https://doaj.org/article/49554280b04c4c7590f8827a3b5ddabe

Separation and Loss of Centrioles From Primordidal Germ Cells To Mature Oocytes In The Mouse

Autor: Jadranka Loncarek, Dong Kong, Calvin Simerly, Carrie Hartnett, Carlos A. Castro, Marion Manil-Ségalen, Marie-Hélène Verlhac, Gerald Schatten

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8, ⟨10.1038/s41598-018-31222-x⟩
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Scientific Reports, Nature Publishing Group, 2018, 8 (1), ⟨10.1038/s41598-018-31222-x⟩

International audience; Oocytes, including from mammals, lack centrioles, but neither the mechanism by which mature eggs lose their centrioles nor the exact stage at which centrioles are destroyed during oogenesis is known. To answer questions raised

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e610afc8c523aabc7b64ed075ef5a2fa
https://hal.archives-ouvertes.fr/hal-03003481

Post-Testicular Sperm Maturation: Centriole Pairs, Found in Upper Epididymis, are Destroyed Prior to Sperm’s Release at Ejaculation

Autor: Kyle E. Orwig, Gerald Schatten, C. C. Lin, Meena Sukhwani, Carlos A. Castro, Carrie Hartnett, Calvin Simerly

Publikováno v: Scientific Reports

The fertilizing sperm’s lengthiest unchartered voyage is through the longest, least-investigated organ in a man’s body – the Epididymis. Over six meters long in men, ~80 meters in stallions and over one-hundred times a mouse’s body length, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50cf41f52d53f5a47b801aada39b3a78