Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Carrie Funk"'
Autor:
Patrick Robert Verhoest, Vinod D. Parikh, Carrie Funk, Marielle Delnomdedieu, Wonkyung Byon, Aarti Sawant Basak, Linda S. Wood, Loretta M. Cox, Hongying Gao, Emily Miller, Chang Lin, Elaine Tseng-Lovering, R S Obach
Publikováno v:
Xenobiotica. 44:438-454
1. In early discovery stages, 2-methyl-N-(2'-(pyrrolidinyl-1-ylsulfonyl)-[1,1'-biphenyl]-4-yl)propan-1-amine (PBPA) demonstrated monoamine oxidase A (MAO-A) and cytochrome P450 (CYP)-mediated clearance. While human liver microsomes predicted low CL(b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b128ee674a78316738ab1a8c083429
https://doi.org/10.3109/00498254.2013.850552
https://doi.org/10.3109/00498254.2013.850552
Autor:
Li Di, R. Scott Obach, Carrie Funk, Jian Lin, Christine C. Orozco, Hui Zhang, Beijing Tan, Thomas S. McDonald, Cheng Chang, Karen Atkinson
Publikováno v:
Drug Metabolism and Disposition. 41:2018-2023
In vitro-in vivo correlation (IVIVC) of intrinsic clearance in preclinical species of rat and dog was established using the hepatocyte relay method to support high-confidence prediction of human pharmacokinetics for low-clearance compounds. Good IVIV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2372c92d91c07410717fce1045d02e5
https://doi.org/10.1124/dmd.113.053322
https://doi.org/10.1124/dmd.113.053322
Autor:
Matthew D. Troutman, John P. Umland, Mary Piotrowski, Veronica Zelesky, Kevin M. Whalen, Jason Gobey, James Federico, Hui Zhang, Theodore E. Liston, Brendon Kapinos, Carrie Funk, Walter Mitchell, Mike West, John S. Janiszewski, Richard P. Schneider
Publikováno v:
Bioanalysis. 4(9)
Background: The number of new chemical entities and types of in vitro and in vivo samples that require bioanalysis in drug discovery is large and diverse. In addition, method development time is limited as data turnaround is the highest priority. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad215c10e3a3f0414bf30a8269041480
https://pubmed.ncbi.nlm.nih.gov/22612685
https://pubmed.ncbi.nlm.nih.gov/22612685