Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Carrie F. Brooks"'
Autor:
Manuel A. Fierro, Beejan Asady, Carrie F. Brooks, David W. Cobb, Alejandra Villegas, Silvia N. J. Moreno, Vasant Muralidharan
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT The endoplasmic reticulum (ER) is thought to play an essential role during egress of malaria parasites because the ER is assumed to be required for biogenesis and secretion of egress-related organelles. However, no proteins localized to the
Externí odkaz:
https://doaj.org/article/e3721d3acf9d446f94b6267c6245c022
Autor:
Sumiti Vinayak, Carrie F. Brooks, Anatoli Naumov, Elena S. Suvorova, Michael W. White, Boris Striepen
Publikováno v:
mBio, Vol 5, Iss 6 (2014)
ABSTRACT Apicomplexa are obligate intracellular parasites that cause important diseases in humans and animals. Manipulating the pathogen genome is the most direct way to understand the functions of specific genes in parasite development and pathogene
Externí odkaz:
https://doaj.org/article/98956d71a29d45efb132e73072f47b57
The deadly human malaria-causing parasite, Plasmodium falciparum relies on its capacity to completely remodel its host red blood cell (RBC) through the export of hundreds of parasite proteins across several membranes to the RBC. Among these exported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4e6aa49dd34cb54ffe9c3e724d365cd
https://doi.org/10.1101/2022.06.30.498261
https://doi.org/10.1101/2022.06.30.498261
Autor:
Swati Agrawal, Duk-Won D Chung, Nadia Ponts, Giel G van Dooren, Jacques Prudhomme, Carrie F Brooks, Elisadra M Rodrigues, John C Tan, Michael T Ferdig, Boris Striepen, Karine G Le Roch
Publikováno v:
PLoS Pathogens, Vol 9, Iss 6, p e1003426 (2013)
Apicomplexan parasites are responsible for numerous important human diseases including toxoplasmosis, cryptosporidiosis, and most importantly malaria. There is a constant need for new antimalarials, and one of most keenly pursued drug targets is an a
Externí odkaz:
https://doaj.org/article/25749d8909aa40a584833210ddcf13ac
Autor:
Carrie F. Brooks, Dylon R. Stephens, Anat Florentin, Rodrigo P. Baptista, Vasant Muralidharan
Publikováno v:
Proc Natl Acad Sci U S A
The human malaria parasite, Plasmodium falciparum, contains an essential plastid called the apicoplast. Most apicoplast proteins are encoded by the nuclear genome and it is unclear how the plastid proteome is regulated. Here, we study an apicoplast-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9eb581d09c4218e90122054adc4a56
https://pubmed.ncbi.nlm.nih.gov/32482878
https://pubmed.ncbi.nlm.nih.gov/32482878
Autor:
Silvia N. J. Moreno, Vasant Muralidharan, Carrie F. Brooks, Beejan Asady, Alejandra Villegas, Manuel A. Fierro, David W. Cobb
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
mBio, Vol 11, Iss 1, p e03078-19 (2020)
mBio
mBio, Vol 11, Iss 1, p e03078-19 (2020)
mBio
The divergent eukaryotic parasites that cause malaria grow and divide within a vacuole inside a host cell, which they have to break open once they finish cell division. The egress of daughter parasites requires the activation of a proteolytic cascade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc14ef2ed4c2648bc4f15bddd13c0b38
https://journals.asm.org/doi/10.1128/mBio.03078-19
https://journals.asm.org/doi/10.1128/mBio.03078-19
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002416 (2011)
Autophagy is a cellular process that is highly conserved among eukaryotes and permits the degradation of cellular material. Autophagy is involved in multiple survival-promoting processes. It not only facilitates the maintenance of cell homeostasis by
Externí odkaz:
https://doaj.org/article/6b6142a5676f4270bf1ee9a0e5c37bbb
Autor:
Alexander Lorestani, Lilach Sheiner, Kevin Yang, Seth D Robertson, Nivedita Sahoo, Carrie F Brooks, David J P Ferguson, Boris Striepen, Marc-Jan Gubbels
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12302 (2010)
The membrane occupation and recognition nexus protein 1 (MORN1) is highly conserved among apicomplexan parasites and is associated with several structures that have a role in cell division. Here we dissected the role of MORN1 using the relatively sim
Externí odkaz:
https://doaj.org/article/c425eba14af54932b956785ccb8f8708
Autor:
Marc-Jan Gubbels, Margaret Lehmann, Mani Muthalagi, Maria E Jerome, Carrie F Brooks, Tomasz Szatanek, Jayme Flynn, Ben Parrot, Josh Radke, Boris Striepen, Michael W White
Publikováno v:
PLoS Pathogens, Vol 4, Iss 2, p e36 (2008)
Apicomplexa are obligate intracellular pathogens that have fine-tuned their proliferative strategies to match a large variety of host cells. A critical aspect of this adaptation is a flexible cell cycle that remains poorly understood at the mechanist
Externí odkaz:
https://doaj.org/article/484811f118a2477ba1bd8a0ead8273e0
Publikováno v:
Methods in Molecular Biology ISBN: 9781493997473
Cryptosporidium parvum can be reliably genetically manipulated using CRISPR/Cas9-driven homologous repair coupled to in vivo propagation within immunodeficient mice. Recent modifications have simplified the initial protocol significantly. This chapte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9fc1239967635e030e914d28d2426d6
https://doi.org/10.1007/978-1-4939-9748-0_13
https://doi.org/10.1007/978-1-4939-9748-0_13