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Autor:
Jeffrey A. Silverman, Carrie D. Scatena, Rachael E. Hawtin, Jeffrey L. Kumer, David E. Stockett, Judith A. Fox
Publikováno v:
Molecular Cancer Therapeutics. 8:C222-C222
Voreloxin is a first-in-class anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II (Stockett et al. and Hawtin et al., AACR 2008). This leads to replication-dependent, site-selective DNA double strand breaks (DSB) target