Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Carrie A. Maxwell"'
Autor:
Richard B. Pyles, Aaron L. Miller, Randall J. Urban, Melinda Sheffield-Moore, Traver J. Wright, Carrie A. Maxwell, Kathleen M. Randolph, Christopher P. Danesi, Kristen A. McGovern, Jayson Vargas, Peyton Armstrong, Lisa Kreber, Giuliana Cumpa, Kevin Randall, Melissa Morrison, Brent E. Masel
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
IntroductionPatients who suffer a traumatic brain injury (TBI) often experience chronic and sometimes debilitating sequelae. Recent reports have illustrated both acute and long-term dysbiosis of the gastrointestinal microbiome with significant altera
Externí odkaz:
https://doaj.org/article/ea558d03be1244bc86d3e8cbf31fae31
Autor:
Derald D. Charles, James R. Fisher, Sarah M. Hoskinson, Audrie A. Medina-Colorado, Yi C. Shen, Mohamad R. Chaaban, Steven G. Widen, Tonyia D. Eaves-Pyles, Carrie A. Maxwell, Aaron L. Miller, Vsevolod L. Popov, Richard B. Pyles
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
The nasal mucosa provides first line defense against inhaled pathogens while creating a unique microenvironment for bacterial communities. Studying the impact of microbiota in the nasal cavity has been difficult due to limitations with current models
Externí odkaz:
https://doaj.org/article/d180af11c248464db2d157a7ecfda0f1
Autor:
Megan H. Amerson-Brown, Aaron L. Miller, Carrie A. Maxwell, Mellodee M. White, Kathleen L. Vincent, Nigel Bourne, Richard B. Pyles
Publikováno v:
Frontiers in Microbiology, Vol 9 (2019)
The human vaginal microbiome (VMB) is a complex bacterial community that interacts closely with vaginal epithelial cells (VECs) impacting the mucosal phenotype and its responses to pathogenic insults. The VMB and VEC relationship includes nutrient ex
Externí odkaz:
https://doaj.org/article/a18a8711281a430c8ae7415fad49cc98
Autor:
Megan H, Amerson-Brown, Aaron L, Miller, Carrie A, Maxwell, Mellodee M, White, Kathleen L, Vincent, Nigel, Bourne, Richard B, Pyles
Publikováno v:
Frontiers in Microbiology
The human vaginal microbiome (VMB) is a complex bacterial community that interacts closely with vaginal epithelial cells (VECs) impacting the mucosal phenotype and its responses to pathogenic insults. The VMB and VEC relationship includes nutrient ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::205b2aa25c7f731b0e69d5f2d3ed7769
https://pubmed.ncbi.nlm.nih.gov/30692980
https://pubmed.ncbi.nlm.nih.gov/30692980
Autor:
Chris J. van Koppen, Scott B. Hoyt, Gino Salituro, Elaine Tung, Jim Tata, Joe Clemas, Mark Rosenbach, Jack Gibson, Daphne Szeto, Wei Tang, Andreas Verras, Lee-Yuh Pai, Ning Ren, Carrie Ann Maxwell, Joe Metzger, Jose Castro-Perez, Qing Chen, Lina Yin, Daniel R. McMasters, Yusheng Xiong, Rolf W. Hartmann, Mary Struthers, Gui-Bai Liang, Charlene Bopp, Xiuying Ma, Gaochao Zhou, Richard Hajdu, Tom Wisniewski, Mike E. Lassman, Nicole Buist, Clare London, Andrea Sok, Gail Forrest, Sloan Stribling, Theresa McLaughlin, Qingzhong Hu, Tian-Quan Cai, Whitney Lane Petrilli
Publikováno v:
ACS Medicinal Chemistry Letters. 6:861-865
Hit-to-lead efforts resulted in the discovery of compound 19, a potent CYP11B2 inhibitor that displays high selectivity vs related CYPs, good pharmacokinetic properties in rat and rhesus, and lead-like physical properties. In a rhesus pharmacodynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e60459ea9849aaebdf1fc299badb367
https://doi.org/10.1021/acsmedchemlett.5b00048
https://doi.org/10.1021/acsmedchemlett.5b00048
Autor:
Marc M. Baum, Lauren N. Dawson, Audrie A. Medina-Colorado, Richard B. Pyles, Kathleen L. Vincent, Elena V. Kozlova, Carrie A. Maxwell, Aaron L. Miller, Trevelyn J. Olive
Publikováno v:
Anaerobe. 45
The human vagina constitutes a complex ecosystem created through relationships established between host mucosa and bacterial communities. In this ecosystem, classically defined strict bacterial aerobes and anaerobes thrive as communities in the micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b1871c4958f7c51060252d578bde68
https://pubmed.ncbi.nlm.nih.gov/28456518
https://pubmed.ncbi.nlm.nih.gov/28456518
Publikováno v:
Current Colorectal Cancer Reports. 8:277-289
Pre-neoplastic lesions (ACF, aberrant-crypt-foci; Hp, hyperplastic/dysplastic polyps) are believed to be precursors of sporadic colorectal-tumors (Ad, adenomas; AdCA, adenocarcinomas). ACF/Hp likely originate due to abnormal growth of colonic-crypts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7dee7d94a1d13cc0884266f4113dc4
https://doi.org/10.1007/s11888-012-0144-3
https://doi.org/10.1007/s11888-012-0144-3
Autor:
Katsutoshi Suetomi, Krishna Rajarathnam, Gregory N. Prado, Carrie A. Maxwell, Aishwarya Ravindran, Javier Navarro, David Shumate
Publikováno v:
Biochemistry. 46:8961-8968
Chemokine IL-8 (CXCL8) binds to its cognate receptors CXCR1 and CXCR2 to induce inflammatory responses, wound healing, tumorogenesis, and neuronal survival. Here we identify the N-loop residues in IL-8 (H18 and F21) and the receptor N-termini as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270f0ca7a00408d9a21859a8b9a3f835
https://doi.org/10.1021/bi7004043
https://doi.org/10.1021/bi7004043
Autor:
Daphne Szeto, Doris F. Cully, Scott B. Hoyt, Ning Ren, Elaine Tung, Charlene Bopp, Jack Gibson, Gino Salituro, Clare London, Jiaqiang Cai, Amjad Ali, Qing Chen, Andrea Sok, Simone Belshaw, Carrie Ann Maxwell, Mark Rosenbach, Gaochao Zhou, Gail Forrest, Tian-Quan Cai, Daniel R. McMasters, Lee-Yuh Pai, Nelo R. Rivera, Sloan Stribling, Emma Carswell, Richard Hajdu, Robinson John E, Andrew J. Cooke, Jeff Kuethe, Tom Wisniewski, Joe Metzger, Thomas R. Clarkson, Gui-Bai Liang, Mary Struthers, Jim Tata, Mike E. Lassman, Lindsay Brown, Wei Tang, Theresa McLaughlin, Xiuying Ma, Nicole Buist, Kun Liu, Joe Clemas, D. Jonathan Bennett, Andreas Verras, Min K. Park, Yusheng Xiong, John Maclean, Jose Castro-Perez
We report the discovery of a benzimidazole series of CYP11B2 inhibitors. Hit-to-lead and lead optimization studies identified compounds such as 32, which displays potent CYP11B2 inhibition, high selectivity versus related CYP targets, and good pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bdb44414988404f1b182298b88bcd9
https://europepmc.org/articles/PMC4434468/
https://europepmc.org/articles/PMC4434468/
Crystallization of Transmembrane Proteins in cubo: Mechanisms of Crystal Growth and Defect Formation
Autor:
Ehud M. Landau, Yasser Qutub, Carrie A. Maxwell, Javier Navarro, Peter G. Vekilov, Ilya Reviakine
Publikováno v:
Journal of Molecular Biology. 343:1243-1254
Crystallization of membrane proteins is a major stumbling block en route to elucidating their structure and understanding their function. The novel concept of membrane protein crystallization from lipidic cubic phases, "in cubo", has yielded well-ord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432b3d547d4ce9775d1320d4d908436e
https://doi.org/10.1016/j.jmb.2004.09.022
https://doi.org/10.1016/j.jmb.2004.09.022