Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Carrie Haskell-Luevano"'
Autor:
Mark D. Ericson, Katie T. Freeman, Travis M. LaVoi, Haley M. Donow, Radleigh G. Santos, Marc A. Giulianotti, Clemencia Pinilla, Richard A. Houghten, Carrie Haskell-Luevano
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10145 (2023)
The melanocortin receptors are involved in numerous physiological pathways, including appetite, skin and hair pigmentation, and steroidogenesis. In particular, the melanocortin-3 receptor (MC3R) is involved in fat storage, food intake, and energy hom
Externí odkaz:
https://doaj.org/article/9855da881bfc4feea75d11f34066b55c
Autor:
Giles S.H. Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M. Koerperich, Mark D. Ericson, Stephanie E. Simonds, Courtney M. Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clément, Michael A. Cowley, Carrie Haskell-Luevano, Lex Van Der Ploeg, Roger A.H. Adan
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101206- (2021)
Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more
Externí odkaz:
https://doaj.org/article/214ce1a22d184bb08a8fd34984c1b999
Autor:
Mark D. Ericson, Courtney M. Larson, Katie T. Freeman, Lennart Nicke, Armin Geyer, Carrie Haskell-Luevano
Publikováno v:
ACS Omega. 7:27656-27663
The melanocortin family is involved in many physiological functions, including pigmentation, steroidogenesis, and appetite. The centrally expressed melanocortin-3 and melanocortin-4 receptors (MC3R and MC4R) possess overlapping but distinct roles in
Autor:
Jarl E. S. Wikberg, Jeffrey B. Tatro, Helgi Schiöth, Colin Pouton, Kathleen G. Mountjoy, Victor J. Hruby, Carrie Haskell-Luevano, Ira Gantz, Tung M. Fong, Sadaf Farooqi, Alex N. Eberle, Roger D. Cone, Adrian J. L. Clark, Biao-Xin Chai, Vanni Caruso
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [41]) are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH). Endogenous anta
Autor:
Courtney M Larson, Radleigh Santos, Richard A. Houghten, Mark D. Ericson, Katie T. Freeman, Zoe M. Koerperich, Rachel H Cho, Haley M. Donow, Clemencia Pinilla, Skye R. Doering, Travis M. Lavoi, Carrie Haskell-Luevano, Marc A. Giulianotti
Publikováno v:
J Med Chem
The melanocortin-4 receptor (MC4R) plays an important role in appetite. Agonist ligands that stimulate the MC4R decrease appetite, while antagonist compounds increase food consumption. Herein, a functional mixture-based positional scan identified nov
Autor:
Phaedra Geer, Marc A. Giulianotti, Skye R. Doering, Travis M. Lavoi, Mark D. Ericson, Radleigh Santos, Katie T. Freeman, Carrie Haskell-Luevano, Richard A. Houghten, Jon R. Appel, Ginamarie Debevec, Clemencia Pinilla
Publikováno v:
J Med Chem
The central melanocortin-3 and melanocortin-4 receptors (MC3R, MC4R) are key regulators of body weight and energy homeostasis. Herein, the discovery and characterization of first-in-class small molecule melanocortin agonists with selectivity for the
Autor:
Katherine N. Schlasner, Mark D. Ericson, Skye R. Doering, Katie T. Freeman, Mary Weinrich, Carrie Haskell-Luevano
Publikováno v:
Molecules, Vol 24, Iss 8, p 1463 (2019)
The five melanocortin receptors (MC1R–MC5R) are involved in numerous biological pathways, including steroidogenesis, pigmentation, and food intake. In particular, MC3R and MC4R knockout mice suggest that the MC3R and MC4R regulate energy homeostasi
Externí odkaz:
https://doaj.org/article/91cade2340a84991869dc61cb9c8d78d
Publikováno v:
ACS Med Chem Lett
[Image: see text] The five melanocortin receptors regulate numerous physiological functions. Although many ligands have been developed for the melanocortin-4 receptor (MC4R), the melanocortin-3 receptor (MC3R) has been less-well characterized, in par
Autor:
Stacey L. Wilber, Katlyn A. Fleming, Carrie Haskell-Luevano, Mary M. Lunzer, Danielle N. Adank, Mark D. Ericson, Zoe M Koeperich
Publikováno v:
ACS Chem Neurosci
There is a critical need to find safe therapeutics to treat an increasingly obese population and diseases associated with an imbalance in energy homeostasis. The melanocortin-3 receptor (MC3R) and melanocortin-4 receptor (MC4R) ligands have long been
Publikováno v:
ACS Medicinal Chemistry Letters. 11:1942-1948
The melanocortin receptors are involved in numerous physiological functions and are regulated by agonists derived from the proopiomelanocortin gene transcript and two endogenous antagonists, agouti and agouti-related protein (AGRP). The key binding a