Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Carri Boiselle"'
Autor:
Edward J. Gane, Jörg Täubel, Björn Pilebro, Marianna Fontana, Justin Kao, Michael Maitland, Mark Stroh, Jessica Seitzer, Jonathan Phillips, Kristy Wood, Yuanxin Xu, Carri Boiselle, Adam Amaral, Adam Boyd, Jeffrey Cehelsky, David Gustein, Odelya Pagovich, Laura Sepp-Lorenzino, Liron Walsh, David Lebwohl, Gillmore Julian
Publikováno v:
Journal of Hepatology. 77:S58-S59
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a0152fb7f220997c2bf31479987769a
https://doi.org/10.1016/s0168-8278(22)00520-7
https://doi.org/10.1016/s0168-8278(22)00520-7
Publikováno v:
Pharmaceutical Research. 35
The renal clearance of fampridine (Fampyra®, or Ampyra®) significantly exceeds the glomerular filtration rate, suggesting active renal secretion is likely the major elimination pathway. The goal of this study was to identify the renal transporters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5d756f1bd2aab2a59c9772865b9d50
https://doi.org/10.1007/s11095-018-2445-y
https://doi.org/10.1007/s11095-018-2445-y
Autor:
Dallas Bednarczyk, Carri Boiselle
Publikováno v:
Xenobiotica. 46:457-466
1. Organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 are polyspecific transporters that mediate the transport of organic acids into hepatocytes. Inactivating mutations of both OATP1B1 and OATP1B3 alleles lead to Rotor syndrome, a disease ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3dd708a523b5fef6323136434583e3
https://doi.org/10.3109/00498254.2015.1085111
https://doi.org/10.3109/00498254.2015.1085111
Autor:
Carri Boiselle, Christina Capacci-Daniel, Mei Xu, Leah Whiteman, Sue Ma, Kai Lin, Christopher T. Jones, Rajiv Chopra, Guoyu Pan, Mitsunori Kato, Zheng Rui, Lei Shu, Keith Hoffmaster, David Barnes-Seeman, Jiping Fu, Jianling Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3979-3985
Herein we report the successful incorporation of a lactam as an amide replacement in the design of hepatitis C virus NS5B Site II thiophene carboxylic acid inhibitors. Optimizing potency in a replicon assay and minimizing potential risk for CYP3A4 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f275e4594d97c9fa8e3656bb50197905
https://doi.org/10.1016/j.bmcl.2014.06.031
https://doi.org/10.1016/j.bmcl.2014.06.031
Publikováno v:
Journal of Pharmaceutical Sciences. 101:1898-1908
It is challenging to predict biliary clearance (CLb) for new chemical entities (NCEs) in early drug discovery. Although sandwich-cultured hepatocyte (SCH) model has offered a valuable tool for characterizing hepatobiliary disposition and drug–drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21660e1d820aab1284438c192728585
https://doi.org/10.1002/jps.23070
https://doi.org/10.1002/jps.23070
Publikováno v:
Drug Metabolism and Pharmacokinetics. 33:S90
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f78d46f7ffcc950a5d95bf0e38785f20
https://doi.org/10.1016/j.dmpk.2017.11.292
https://doi.org/10.1016/j.dmpk.2017.11.292
Autor:
Carri Boiselle, Dallas Bednarczyk
Publikováno v:
The FASEB Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acfb0120c93cf936de63919e2849178a
https://doi.org/10.1096/fasebj.29.1_supplement.939.2
https://doi.org/10.1096/fasebj.29.1_supplement.939.2