A Mechanism for Antibody-mediated Outside-in Activation of LFA-1

Autor: Carreño, Roberto, Li, Dan, Sen, Mehmet, Nira, Iris, Yamakawa, Tatsuo, Ma, Qing, Legge, Glen B.

Publikováno v: In Journal of Biological Chemistry 18 April 2008 283(16):10642-10648

2E8 Binds to the High Affinity I-domain in a Metal Ion-dependent Manner: A SECOND GENERATION MONOCLONAL ANTIBODY SELECTIVELY TARGETING ACTIVATED LFA-1*

Autor: Carreño, Roberto, Brown, Wells S., Li, Dan, Hernandez, Jessica A., Wang, Yang, Kim, Tae Kon, Craft, John W., Komanduri, Krishna V., Radvanyi, Laszlo G., Hwu, Patrick, Molldrem, Jeffrey J., Legge, Glen B., McIntyre, Bradley W., Ma, Qing

The activation of leukocyte function-associated antigen-1 (LFA-1) plays a critical role in regulating immune responses. The metal ion-dependent adhesion site on the I-domain of LFA-1 α(L) subunit is the key recognition site for ligand binding. Upon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a66199cb677574f5e0e9f6415187bf07
https://europepmc.org/articles/PMC2963386/

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2E8 binds to the high affinity I-domain in a metal ion-dependent manner: a second generation monoclonal antibody selectively targeting activated LFA-1.

Autor: Carreño R; From the Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, Houston, Texas 77030., Brown WS; Department of Immunology, Houston, Texas 77030., Li D; From the Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, Houston, Texas 77030., Hernandez JA; Department of Melanoma Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030., Wang Y; From the Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, Houston, Texas 77030., Kim TK; Adult Stem Cell Transplant Program, University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida 33136., Craft JW Jr; Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204., Komanduri KV; Adult Stem Cell Transplant Program, University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida 33136., Radvanyi LG; Department of Melanoma Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030., Hwu P; Department of Melanoma Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030., Molldrem JJ; From the Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, Houston, Texas 77030., Legge GB; Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204., McIntyre BW; Department of Immunology, Houston, Texas 77030., Ma Q; From the Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, Houston, Texas 77030. Electronic address: qma@mdanderson.org.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2010 Oct 22; Vol. 285 (43), pp. 32860-32868. Date of Electronic Publication: 2010 Aug 19.