Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles.

Autor: Huffman JE; Palo Alto VA Institute for Research, VA Palo Alto Heath Care System, Palo Alto, CA.; MAVERIC, VA Boston Healthcare System, Boston, MA., Nicholas J; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Hahn J; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Heath AS; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA., Thibord F; National Heart, Lung, and Blood Institute, Division of Intramural Research, Population Sciences Branch, The Framingham Heart Study, Framingham, MA., Almasy L; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA., Bartz TM; Department of Biostatistics, University of Washington, Seattle, WA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI., Bowler RP; National Jewish Health, Denver, CO., Carrasquilla GD; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Chen MH; National Heart, Lung, and Blood Institute, Division of Intramural Research, Population Sciences Branch, The Framingham Heart Study, Framingham, MA., Emmert DB; Institute for Biomedicine (affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy., Ghanbari M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Haessler J; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA., Hottenga JJ; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Kleber ME; SYNLAB MVZ für Humangenetik Mannheim, Mannheim, Germany.; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Le NQ; Unit of Genomics of Complex Disease, Institut d'Investigació Biomèdica Sant Pau, Barcelona, Spain., Lee J; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Lewis JP; Department of Medicine, University of Maryland, Baltimore, MD., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Malmberg A; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland., Mangino M; Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom.; National Institute for Health and Care Research Biomedical Research Centre, Guy's and St Thomas' Foundation Trust, London, United Kingdom., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, United Kingdom., Martinez-Perez A; Unit of Genomics of Complex Disease, Institut de Recerca Sant Paul, Barcelona, Spain.; Centre for Biomedical Network Research on Rare Diseases, Instituto de Salud Carlos III, Madrid, Spain., Pankratz N; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Richmond A; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, United Kingdom., Rodriguez BAT; National Heart, Lung, and Blood Institute, Division of Intramural Research, Population Sciences Branch, The Framingham Heart Study, Framingham, MA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Steri M; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato-Cagliari, Italy., Suchon P; Centre de Recherche en Cardiovascular et Nutrition, INSERM, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Aix Marseille University, Marseille, France.; Laboratory of Haematology, La Timone Hospital, Marseille, France., Trompet S; Section of Gerontology and Geriatrics, Department of Internal Medicin, Leiden University Medical Center, Leiden, The Netherlands., Weiss S; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, German Center for Cardiovascular Research, Partner Site Greifswald, University Medicine Greifswald, Greifswald, Germany., Zare M; Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Auer P; Division of Biostatistics, Institute for Health and Equity, and Cancer Center, Medical College of Wisconsin, Milwaukee, WI., Cho MH; Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Christofidou P; Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom., Davies G; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, Scotland, United Kingdom., de Geus E; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Deleuze JF; Centre National de Recherche en Génomique Humaine, Commissariat a l'Energie Atomique et aux Energies Alternatives, Université Paris-Saclay, Evry, France., Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Ekunwe L; Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS., Faraday N; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Gögele M; Institute for Biomedicine (affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy., Greinacher A; Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany., Gao H; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.; Medical Research Council-Public Health England Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom., Howard T; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX., Joshi PK; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lahti J; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Naitza S; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato-Cagliari, Italy., Noordam R; Section of Gerontology and Geriatrics, Department of Internal Medicin, Leiden University Medical Center, Leiden, The Netherlands., Paüls-Vergés F; Unit of Genomics of Complex Disease, Institut d'Investigació Biomèdica Sant Pau, Barcelona, Spain., Rich SS; Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Rudan I; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland., Ryan KA; Department of Medicine, University of Maryland, Baltimore, MD., Souto JC; Unit of Genomics of Complex Disease, Institut de Recerca Sant Paul, Barcelona, Spain.; Centre for Biomedical Network Research on Rare Diseases, Instituto de Salud Carlos III, Madrid, Spain.; Unit of Thrombosis and Hemostasis, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., van Rooij FJA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Wang H; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI., Becker LC; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Beswick A; Translational Health Sciences, University of Bristol, Bristol, United Kingdom., Brown MR; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Cade BE; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Campbell H; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland., Cho K; MAVERIC, VA Boston Healthcare System, Boston, MA.; Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA., Crapo JD; National Jewish Health, Denver, CO., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX., de Maat MPM; Department of Hematology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Doyle M; Department of Pathology and Laboratory Medicine, The University of Vermont Larner College of Medicine, Colchester, VT., Elliott P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.; Medical Research Council-Public Health England Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.; United Kingdom-Dementia Research Institute, Imperial College London, London, United Kingdom., Floyd JS; Departments of Medicine and Epidemiology, University of Washington, Seattle, WA., Fuchsberger C; Institute for Biomedicine (affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Harris SE; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, Scotland, United Kingdom., Hou L; Department of Preventive Medicine, Northwestern University, Chicago, IL., Kolcic I; Faculty of Medicine, University of Split, Split, Croatia., Kooperberg C; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA., Menni C; Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom., Nauck M; Institute of Clinical Chemistry and Laboratory Medicine, German Center for Cardiovascular Research, Partner Site Greifswald, Greifswald, Germany, University Medicine Greifswald, Greifswald, Germany., O'Connell JR; Department of Medicine, University of Maryland, Baltimore, MD., Orrù V; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Lanusei, Italy., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA., Räikkönen K; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI., Soria JM; Unit of Genomics of Complex Disease, Institut de Recerca Sant Paul, Barcelona, Spain.; Centre for Biomedical Network Research on Rare Diseases, Instituto de Salud Carlos III, Madrid, Spain., Stott DJ; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom., van Hylckama Vlieg A; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Watkins H; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Willemsen G; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Wilson PWF; VA Atlanta Healthcare System, Decatur, GA.; Division of Cardiology, Emory University School of Medicine, Atlanta, GA.; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA., Ben-Shlomo Y; Poulation Health Sciences, University of Bristol, Bristol, United Kingdom., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX., Boomsma D; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Cox SR; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, Scotland, United Kingdom., Dehghan A; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.; Medical Research Council-Public Health England Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.; United Kingdom-Dementia Research Institute, Imperial College London, London, United Kingdom., Eriksson JG; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore., Fiorillo E; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Lanusei, Italy., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, United Kingdom., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO., März W; Synlab Academy, Synlab Holding Deutschland GmbH, and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Mathias RA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Mitchell BD; Department of Medicine, University of Maryland, Baltimore, MD.; Geriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., Morange PE; Centre de Recherche en Cardiovascular et Nutrition, INSERM, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Aix Marseille University, Marseille, France.; Laboratory of Haematology, La Timone Hospital, Marseille, France., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pramstaller PP; Institute for Biomedicine (affiliated to the University of Lübeck), Eurac Research, Bolzano, Italy., Redline S; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Department of Medicine, Beth Israel Deaconness Medical Center, Boston, MA., Reiner A; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Silverman EK; Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Spector TD; Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom., Völker U; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, German Center for Cardiovascular Research, Partner Site Greifswald, University Medicine Greifswald, Greifswald, Germany., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Wilson JF; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, United Kingdom.; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Trégouët DA; Bordeaux Population Health Research Center, INSERM UMR 1219, University of Bordeaux, Bordeaux, France., Johnson AD; National Heart, Lung, and Blood Institute, Division of Intramural Research, Population Sciences Branch, The Framingham Heart Study, Framingham, MA., Wolberg AS; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC., de Vries PS; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Sabater-Lleal M; Unit of Genomics of Complex Disease, Institut de Recerca Sant Paul, Barcelona, Spain.; Centre for Biomedical Network Research on Rare Diseases, Instituto de Salud Carlos III, Madrid, Spain.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden., Morrison AC; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Smith NL; Department of Epidemiology, University of Washington, Seattle, WA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA.; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA.

Publikováno v: Blood [Blood] 2024 Nov 21; Vol. 144 (21), pp. 2248-2265.

A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels.

Autor: de Vries PS; Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Reventun P; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Brown MR; Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Heath AS; Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Huffman JE; Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA., Le NQ; Unit of Genomics of Complex Disease, Institut de Recerca Sant Pau, Barcelona, Spain., Bebo A; Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA., Temprano-Sagrera G; Unit of Genomics of Complex Disease, Institut de Recerca Sant Pau, Barcelona, Spain., Raffield LM; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Ozel AB; Department of Human Genetics, University of Michigan, Ann Arbor, MI., Thibord F; Division of Intramural Research, Population Sciences Branch, National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, MA., Jain D; Department of Biostatistics, Genetic Analysis Center, School of Public Health, University of Washington, Seattle, WA., Lewis JP; Department of Medicine, University of Maryland, Baltimore, MD., Rodriguez BAT; Division of Intramural Research, Population Sciences Branch, National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, MA., Pankratz N; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Taylor KD; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Chen MH; Division of Intramural Research, Population Sciences Branch, National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, MA., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Carrasquilla GD; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland., Kleber ME; SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany.; Fifth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Trégouët DA; INSERM UMR 1219, Bordeaux Population Health Research Center, Bordeaux, France., Yao J; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Trompet S; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Martinez-Perez A; Unit of Genomics of Complex Disease, Institut de Recerca Sant Pau, Barcelona, Spain., Ghanbari M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Howard TE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX., Reiner AP; Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA., Arvanitis M; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Ryan KA; Department of Medicine, University of Maryland, Baltimore, MD., Bartz TM; Departments of Biostatistics and Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA., Rudan I; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Faraday N; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ekunwe L; Department of Medicine, University of Mississippi Medical Center, Jackson, MS., Davies G; Department of Psychology, Lothian Birth Cohorts, University of Edinburgh, Edinburgh, Scotland., Delgado GE; Fifth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Suchon P; C2VN, INSERM, INRAE, Aix Marseille University, Marseille, France.; Laboratory of Haematology, La Timone Hospital, Marseille, France., Guo X; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Klaric L; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., van Rooij F; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX., Wheeler MM; Department of Genome Sciences, University of Washington, Seattle, WA., Osburn WO; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., O'Connell JR; Department of Medicine, University of Maryland, Baltimore, MD., Boerwinkle E; Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX., Beswick A; Translational Health Sciences, University of Bristol, Bristol, United Kingdom., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Departments of Epidemiology and Health Systems and Population Health, Seattle, WA., Kolcic I; Faculty of Medicine, University of Split, Split, Croatia., Souto JC; Unit of Genomics of Complex Disease, Institut de Recerca Sant Pau, Barcelona, Spain.; Unit of Thrombosis and Hemostasis, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Becker LC; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Doyle MF; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Colchester, VT., Harris SE; Department of Psychology, Lothian Birth Cohorts, University of Edinburgh, Edinburgh, Scotland., Moissl AP; Institute of Nutritional Sciences, Friedrich-Schiller-University Jena, Jena, Germany.; Competence Cluster for Nutrition and Cardiovascular Health Halle-Jena-Leipzig, Jena, Germany., Deleuze JF; Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, CEA, Evry, France.; Centre d'Etude du Polymorphisme Humain, Fondation Jean Dausset, Paris, France., Rich SS; Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, VA., van Hylckama Vlieg A; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Stott DJ; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland., Soria JM; Unit of Genomics of Complex Disease, Institut de Recerca Sant Pau, Barcelona, Spain., de Maat MPM; Department of Hematology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Almasy L; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA., Brody LC; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD., Auer PL; Department of Biostatistics, Medical College of Wisconsin, Milwaukee, WI., Mitchell BD; Department of Medicine, University of Maryland, Baltimore, MD.; Geriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD., Ben-Shlomo Y; Population Health Sciences, University of Bristol, Bristol, United Kingdom., Fornage M; Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland., Mathias RA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Lange LA; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO., Cox SR; Department of Psychology, Lothian Birth Cohorts, University of Edinburgh, Edinburgh, Scotland., März W; Fifth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany., Morange PE; C2VN, INSERM, INRAE, Aix Marseille University, Marseille, France.; Laboratory of Haematology, La Timone Hospital, Marseille, France., Rotter JI; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland., van der Harst P; Division of Heart and Lungs, Department of Cardiology, Utrecht University, University Medical Center Utrecht, Utrecht, The Netherlands., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX., Kooperberg C; Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA., Desch KC; Department of Pediatrics, University of Michigan, C.S. Mott Children's Hospital, Ann Arbor, MI., Johnson AD; Division of Intramural Research, Population Sciences Branch, National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, MA., Sabater-Lleal M; Unit of Genomics of Complex Disease, Institut de Recerca Sant Pau, Barcelona, Spain.; Department of Medicine, Cardiovascular Medicine Unit, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden., Lowenstein CJ; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Smith NL; Department of Epidemiology, University of Washington, Seattle, WA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA.; Department of Veterans Affairs Office of Research and Development, Seattle Epidemiologic and Information Center, Seattle, WA., Morrison AC; Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.

Publikováno v: Blood [Blood] 2024 May 02; Vol. 143 (18), pp. 1845-1855.

Sociodemographic characteristics and COVID-19 testing rates: spatiotemporal patterns and impact of test accessibility in Sweden.

Autor: Kennedy B; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Varotsis G; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Hammar U; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Nguyen D; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Carrasquilla GD; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., van Zoest V; Department of Information Technology, Division of Systems and Control, Uppsala University, Uppsala, Sweden.; Department of Systems Science for Defence and Security, Swedish Defence University, Stockholm, Sweden., Kristiansson RS; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Fitipaldi H; Diabetic Complications Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund, Sweden., Dekkers KF; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Daivadanam M; Global Health and Migration Unit, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden., Martinell M; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Björk J; Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.; Clinical Studies Sweden, Forum South, Skåne University Hospital, Lund, Sweden., Fall T; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Publikováno v: European journal of public health [Eur J Public Health] 2024 Feb 05; Vol. 34 (1), pp. 14-21.

Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity.

Autor: Carrasquilla GD; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., García-Ureña M; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Fall T; Molecular Epidemiology, Department of Medical Sciences, and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Sørensen TIA; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: ELife [Elife] 2022 Mar 07; Vol. 11. Date of Electronic Publication: 2022 Mar 07.

FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer.

Autor: Thibord F; The Framingham Heart Study, National Heart Lung and Blood Institute, Framingham, Massachusetts, USA., Song C; The Framingham Heart Study, National Heart Lung and Blood Institute, Framingham, Massachusetts, USA., Pattee J; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA., Rodriguez BAT; The Framingham Heart Study, National Heart Lung and Blood Institute, Framingham, Massachusetts, USA., Chen MH; The Framingham Heart Study, National Heart Lung and Blood Institute, Framingham, Massachusetts, USA., O'Donnell CJ; The Framingham Heart Study, National Heart Lung and Blood Institute, Framingham, Massachusetts, USA.; U.S. Department of Veterans Affairs, Boston, Massachusetts, USA., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; SYNLAB MVZ Humangenetik Mannheim GmbH, Mannheim, Germany., Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Guo X; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA., Yao J; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA., Taylor KD; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA., Ozel AB; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Brody JA; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, Washington, USA., McKnight B; Department of Biostatistics, University of Washington, Seattle, Washington, USA., Gyorgy B; INSERM UMRS1166, ICAN - Institute of CardioMetabolism and Nutrition, Sorbonne Université, Paris, France., Simonsick E; National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA., Leonard HL; National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA., Carrasquilla GD; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Guindo-Martinez M; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Silveira A; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Center for Molecular Medicine and Karolinska University Hospital Solna, Stockholm, Sweden., Temprano-Sagrera G; Genomics of Complex Diseases, Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain., Yanek LR; GeneSTAR Research Program, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Becker DM; GeneSTAR Research Program, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Mathias RA; GeneSTAR Research Program, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.; Division of Allergy and Clinical Immunology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Becker LC; GeneSTAR Research Program, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.; Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Kilpeläinen TO; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Grarup N; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Pedersen O; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Hansen T; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Center for Molecular Medicine and Karolinska University Hospital Solna, Stockholm, Sweden., Watkins H; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Sabater-Lleal M; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Center for Molecular Medicine and Karolinska University Hospital Solna, Stockholm, Sweden.; Genomics of Complex Diseases, Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain., Nalls MA; National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA., Trégouët DA; INSERM UMRS1166, ICAN - Institute of CardioMetabolism and Nutrition, Sorbonne Université, Paris, France.; INSERM, BPH, Univ. Bordeaux, Bordeaux, France., Morange PE; INSERM, INRAE, Aix-Marseille Univ, Marseille, France., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, Washington, USA., Tracy RP; Department of Pathology and Laboratory Medicine & Department of Medicine, Vermont Center on Cardiovascular and Brain Health, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA., Smith NL; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, Washington, USA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Department of Veterans Affairs Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle,, Washington, USA., Desch KC; Department of Pediatrics, Cell and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, USA., Cushman M; Department of Pathology and Laboratory Medicine & Department of Medicine, Vermont Center on Cardiovascular and Brain Health, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA., Rotter JI; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA., de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Pankratz ND; Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Folsom AR; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany., Tang W; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA., Johnson AD; The Framingham Heart Study, National Heart Lung and Blood Institute, Framingham, Massachusetts, USA.

Publikováno v: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2021 Aug; Vol. 19 (8), pp. 2019-2028. Date of Electronic Publication: 2021 May 30.