A cell topography-based mechanism for ligand discrimination by the T cell receptor

Autor: Fernandes, Ricardo A., Ganzinger, Kristina A., Tzou, Justin C., Jönsson, Peter, Lee, Steven F., Palayret, Matthieu, Santos, Ana Mafalda, Carr, Alexander R., Ponjavic, Aleks, Chang, Veronica T., Macleod, Charlotte, Lagerholm, B. Christoffer, Lindsay, Alan E., Dushek, Omer, Tilevik, Andreas, Davis, Simon J., Klenerman, David

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2019 Jul 01. 116(28), 14002-14010.

Externí odkaz: https://www.jstor.org/stable/26760980

Single-molecule light-sheet imaging of suspended T cells

Autor: Ponjavic, Aleks, McColl, James, Carr, Alexander R, Santos, Ana Mafalda, Kulenkampff, Klara, Lippert, Anna, Davis, Simon J, Klenerman, David, Lee, Steven F

Adaptive immune responses are initiated by triggering of the T cell receptor. Single-molecule imaging based on total internal reflection fluorescence microscopy at coverslip/basal cell interfaces is commonly used to study this process. These experime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4087bde20463fb76ccb3e0deb6c31fdf
https://doi.org/10.1016/j.bpj.2018.02.044

Accelerating paint superresolution imaging by active probe control

Autor: Sanders, Edward W., Carr, Alexander R., Bruggeman, Ezra, Koerbel, Markus, Mafalda Santos, Ana, McColl, James T., O'Holleran, Kevin, Klenerman, David, Davis, Simon J., Ponjavic, Aleks, Lee, Steven F.

Publikováno v: In Biophysical Journal 11 February 2022 121(3) Supplement 1:140a-140a

Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale

Autor: Lee, Ji-eun, Sang, Jason C., Rodrigues, Margarida, Carr, Alexander R., Horrocks, Mathew H., De, Suman, Bongiovanni, Marie N., Flagmeier, Patrick, Dobson, Christopher M., Wales, David J., Lee, Steven F., Klenerman, David

Publikováno v: Nano Letters
Lee, J, Sang, J C, Rodrigues, M, Carr, A R, Horrocks, M H, De, S, Bongiovanni, M N, Flagmeier, P, Dobson, C M, Wales, D J, Lee, S F & Klenerman, D 2018, ' Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale ', Nano Letters . https://doi.org/10.1021/acs.nanolett.8b02916

Proteins fold into a single structural ensemble but can also misfold into many diverse structures including small aggregates and fibrils, which differ in their toxicity. The aggregate surface properties play an important role in how they interact wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ac113edf9271edc6c2ee5a32ed36b1f9

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