Dynamic Density Functional Theory of Multicomponent Cellular Membranes

Autor: Stanton, Liam G., Oppelstrup, Tomas, Carpenter, Timothy S., Ingólfsson, Helgi I., Surh, Michael P., Lightstone, Felice C., Glosli, James N.

We present a continuum model trained on molecular dynamics (MD) simulations for cellular membranes composed of an arbitrary number of lipid types. The model is constructed within the formalism of dynamic density functional theory and can be extended

Externí odkaz: http://arxiv.org/abs/2112.08651

Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane.

Autor: Shrestha, Rebika¹ (AUTHOR), Carpenter, Timothy S.² (AUTHOR), Van, Que N.¹ (AUTHOR), Agamasu, Constance¹ (AUTHOR), Tonelli, Marco³ (AUTHOR), Aydin, Fikret² (AUTHOR), Chen, De¹ (AUTHOR), Gulten, Gulcin¹ (AUTHOR), Glosli, James N.² (AUTHOR), López, Cesar A.⁴ (AUTHOR), Oppelstrup, Tomas² (AUTHOR), Neale, Chris⁴ (AUTHOR), Gnanakaran, Sandrasegaram⁴ (AUTHOR), Gillette, William K.¹ (AUTHOR), Ingólfsson, Helgi I.² (AUTHOR), Lightstone, Felice C.² (AUTHOR), Stephen, Andrew G.¹ (AUTHOR), Streitz, Frederick H.² (AUTHOR), Nissley, Dwight V.¹ (AUTHOR), Turbyville, Thomas J.¹ (AUTHOR) thomas.turbyville@nih.gov

Publikováno v: Communications Biology. 2/17/2024, Vol. 7 Issue 1, p1-16. 16p.

Exploring CRD mobility during RAS/RAF engagement at the membrane

Autor: Nguyen, Kien, López, Cesar A., Neale, Chris, Van, Que N., Carpenter, Timothy S., Di Natale, Francesco, Travers, Timothy, Tran, Timothy H., Chan, Albert H., Bhatia, Harsh, Frank, Peter H., Tonelli, Marco, Zhang, Xiaohua, Gulten, Gulcin, Reddy, Tyler, Burns, Violetta, Oppelstrup, Tomas, Hengartner, Nick, Simanshu, Dhirendra K., Bremer, Peer-Timo, Chen, De, Glosli, James N., Shrestha, Rebika, Turbyville, Thomas, Streitz, Frederick H., Nissley, Dwight V., Ingólfsson, Helgi I., Stephen, Andrew G., Lightstone, Felice C., Gnanakaran, Sandrasegaram

Publikováno v: In Biophysical Journal 4 October 2022 121(19):3630-3650

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Pharmacological characterization of the neurotrophic sesquiterpene jiadifenolide reveals a non-convulsant signature and potential for progression in neurodegenerative disease studies

Autor: Witkin, Jeffrey M., Shenvi, Ryan A., Li, Xia, Gleason, Scott D., Weiss, Julie, Morrow, Denise, Catow, John T., Wakulchik, Mark, Ohtawa, Masaki, Lu, Hai-Hua, Martinez, Michael D., Schkeryantz, Jeffrey M., Carpenter, Timothy S., Lightstone, Felice C., Cerne, Rok

Publikováno v: In Biochemical Pharmacology September 2018 155:61-70