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Clearing Things Up: A Vertical Mucus Clearance Assay to Investigate Rheological and Biochemical Parameters Governing Mucociliary Clearance

Autor: Carpenter, Jerome

Mucociliary clearance (MCC) plays an essential role to protect the airways from pathogens and pollutants. Impaired MCC leads to a host of diseases and initiates a cascade of chronic infection, inflammation, and reduced lung function. Understanding th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebce4dc85446105ea330232534f726f2

Mucus polymer concentration and in vivo adaptation converge to define the antibiotic response of Pseudomonas aeruginosa during chronic lung infection.

Autor: Greenwald MA; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.; Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina, USA., Meinig SL; Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina, USA., Plott LM; Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina, USA., Roca C; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.; Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina, USA., Higgs MG; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.; Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina, USA., Vitko NP; Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina, USA., Markovetz MR; Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina, USA., Rouillard KR; Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina, USA., Carpenter J; Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina, USA., Kesimer M; Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina, USA., Hill DB; Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina, USA.; Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina, USA., Schisler JC; Department of Pharmacology, The University of North Carolina, Chapel Hill, North Carolina, USA.; McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina, USA., Wolfgang MC; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.; Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina, USA.

Publikováno v: MBio [mBio] 2024 Jun 12; Vol. 15 (6), pp. e0345123. Date of Electronic Publication: 2024 Apr 23.