Microglia morphological response to mesenchymal stromal cell extracellular vesicles demonstrates EV therapeutic potential for modulating neuroinflammation.

Autor: Daga, Kanupriya R., Larey, Andrew M., Morfin, Maria G., Chen, Kailin, Bitarafan, Sara, Carpenter, Jana M., Hynds, Hannah M., Hines, Kelly M., Wood, Levi B., Marklein, Ross A.

Publikováno v: Journal of Biological Engineering; 10/17/2024, Vol. 18 Issue 1, p1-21, 21p

Microglia Morphological Response to Mesenchymal Stromal Cell Extracellular Vesicles Demonstrates EV Therapeutic Potential for Modulating Neuroinflammation.

Autor: Daga KR; School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, USA.; Regenerative Bioscience Center, University of Georgia, Athens, GA, USA., Larey AM; School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, USA.; Regenerative Bioscience Center, University of Georgia, Athens, GA, USA., Morfin MG; School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, USA., Chen K; Regenerative Bioscience Center, University of Georgia, Athens, GA, USA.; Franklin College of Arts and Sciences, University of Georgia, Athens, GA, USA., Bitarafan S; George W. Woodruff School of Mechanical Engineering and Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA., Carpenter JM; Department of Chemistry, University of Georgia, Athens, GA, USA., Hynds HM; Department of Chemistry, University of Georgia, Athens, GA, USA., Hines KM; Department of Chemistry, University of Georgia, Athens, GA, USA., Wood LB; George W. Woodruff School of Mechanical Engineering and Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA., Marklein RA; School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, USA.; Regenerative Bioscience Center, University of Georgia, Athens, GA, USA.; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 03. Date of Electronic Publication: 2024 Jul 03.

High throughput screening of mesenchymal stromal cell morphological response to inflammatory signals for bioreactor-based manufacturing of extracellular vesicles that modulate microglia.

Autor: Larey AM; School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, USA.; Regenerative Bioscience Center, University of Georgia, Athens, GA, USA., Spoerer TM; School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, USA.; Regenerative Bioscience Center, University of Georgia, Athens, GA, USA., Daga KR; School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, USA.; Regenerative Bioscience Center, University of Georgia, Athens, GA, USA., Morfin MG; Regenerative Bioscience Center, University of Georgia, Athens, GA, USA., Hynds HM; Department of Chemistry, University of Georgia, Athens, GA, USA., Carpenter J; Department of Chemistry, University of Georgia, Athens, GA, USA., Hines KM; Department of Chemistry, University of Georgia, Athens, GA, USA., Marklein RA; School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA, USA.; Regenerative Bioscience Center, University of Georgia, Athens, GA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 19. Date of Electronic Publication: 2023 Nov 19.