Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model of Parkinson's disease.

Autor: Böck D; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Wilhelm M; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Mumenthaler J; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Carpanese DF; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Kulcsár PI; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., d'Aquin S; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Cremonesi A; Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland., Rassi A; Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland., Häberle J; Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland., Patriarchi T; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland., Schwank G; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.

Publikováno v: ELife [Elife] 2024 Dec 23; Vol. 13. Date of Electronic Publication: 2024 Dec 23.