Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

Autor: Eoin D. O’Sullivan, Katie J. Mylonas, Rachel Bell, Cyril Carvalho, David P. Baird, Carolynn Cairns, Kevin M. Gallagher, Ross Campbell, Marie Docherty, Alexander Laird, Neil C. Henderson, Tamir Chandra, Kristina Kirschner, Bryan Conway, Gry H. Dihazi, Michael Zeisberg, Jeremy Hughes, Laura Denby, Hassan Dihazi, David A. Ferenbach

Publikováno v: JCI Insight, Vol 7, Iss 22 (2022)

Progressive fibrosis and maladaptive organ repair result in significant morbidity and millions of premature deaths annually. Senescent cells accumulate with aging and after injury and are implicated in organ fibrosis, but the mechanisms by which sene

Externí odkaz: https://doaj.org/article/4b3de86c4fb74e508d5ddb5a3c0e0003

Transcription controls growth, cell kinetics and cholesterol supply to sustain ACTH responses

Autor: Robert I Menzies, Xin Zhao, Linda J Mullins, John J Mullins, Carolynn Cairns, Nicola Wrobel, Donald R Dunbar, Matthew A Bailey, Christopher J Kenyon

Publikováno v: Endocrine Connections, Vol 6, Iss 7, Pp 446-457 (2017)

Chronic ACTH exposure is associated with adrenal hypertrophy and steroidogenesis. The underlying molecular processes in mice have been analysed by microarray, histological and immunohistochemical techniques. Synacthen infused for 2 weeks markedly inc

Externí odkaz: https://doaj.org/article/604365f401a94798b5d7a9d9fb79dcb4

Administration of heme arginate ameliorates murine type 2 diabetes independently of heme oxygenase activity.

Autor: Abhijeet K Choudhary, Jillian Rennie, Carolynn Cairns, Gary Borthwick, Jeremy Hughes, Nicholas M Morton, David Kluth, Bryan R Conway

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e78209 (2013)

Amelioration of rodent type 2 diabetes by hemin has been linked to increased heme oxygenase (HO) activity, however alternative mechanisms have recently been proposed for its anti-diabetic effect. We sought to determine the anti-diabetic efficacy of h

Externí odkaz: https://doaj.org/article/bb26140a62d145c9880c291e82253660

Endothelin-1 Mediates the Systemic and Renal Hemodynamic Effects of GPR81 Activation

Autor: Dawn E W Livingstone, John J. Mullins, Kevin Stewart, John Wiseman, James W. Dear, Carmel M. Moran, Bryan R. Conway, Patrick W. F. Hadoke, Laura Denby, Robert I. Menzies, Matthew A. Bailey, Natalie K. Jones, David J. Webb, Alicja Czopek, Adrian Thomson, Carolynn Cairns, Neeraj Dhaun

Publikováno v: Jones, N, Stewart, K, Czopek, A, Menzies, R, Thomson, A W, Moran, C, Cairns, C, Conway, B, Denby, L, Livingstone, D, Wiseman, J, Hadoke, P, Webb, D, Dhaun, N, Dear, J, Mullins, J & Bailey, M 2020, ' Endothelin-1 mediates the systemic and renal hemodynamic effects of GPR81 activation ', Hypertension . https://doi.org/10.1161/HYPERTENSIONAHA.119.14308
Hypertension (Dallas, Tex. : 1979)

Supplemental Digital Content is available in the text.
GPR81 (G-protein-coupled receptor 81) is highly expressed in adipocytes, and activation by the endogenous ligand lactate inhibits lipolysis. GPR81 is also expressed in the heart, liver, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db93e9f8bfa30f8527af2997cc8ba983
https://doi.org/10.1161/hypertensionaha.119.14308

Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease

Autor: Cécile Bénézech, Carolynn Cairns, Oliver Teenan, Katie Connor, James O’sullivan, Angela Salzano, David A. Ferenbach, Kevin Stewart, Eoin O'Sullivan, Neil C. Henderson, Peng Ding, Riinu Pius, Jeremy Hughes, Tamir Chandra, Laura Denby, Duncan Humphries, Prakash Ramachandran, Bryan R. Conway, Daniel J. Simpson

Publikováno v: J Am Soc Nephrol
Conway, B R, O Sullivan, E, Cairns, C, O'Sullivan, J, Simpson, D, Salzano, A, Connor, K, Ding, P, Humphries, D, Stewart, K, Teenan, O, Pius, R, Henderson, N C, Benezech, C, Ramachandran, P, Ferenbach, D A, Hughes, J, Chandra, T & Denby, L 2020, ' Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease ', Journal of the American Society of Nephrology, vol. 31, no. 12, pp. 2833–2854 . https://doi.org/10.1681/ASN.2020060806

Background Little is known about the roles of myeloid cell subsets in kidney injury and in the limited ability of the organ to repair itself. Characterizing these cells based only on surface markers using flow cytometry might not provide a full pheno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c985622a807b7b39dbcfe20eb66ca7
https://pubmed.ncbi.nlm.nih.gov/32978267