Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Carolynn Cairns"'
Autor:
Eoin D. O’Sullivan, Katie J. Mylonas, Rachel Bell, Cyril Carvalho, David P. Baird, Carolynn Cairns, Kevin M. Gallagher, Ross Campbell, Marie Docherty, Alexander Laird, Neil C. Henderson, Tamir Chandra, Kristina Kirschner, Bryan Conway, Gry H. Dihazi, Michael Zeisberg, Jeremy Hughes, Laura Denby, Hassan Dihazi, David A. Ferenbach
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Progressive fibrosis and maladaptive organ repair result in significant morbidity and millions of premature deaths annually. Senescent cells accumulate with aging and after injury and are implicated in organ fibrosis, but the mechanisms by which sene
Externí odkaz:
https://doaj.org/article/4b3de86c4fb74e508d5ddb5a3c0e0003
Autor:
Katie L. Connor, Oliver Teenan, Carolynn Cairns, Victoria Banwell, Rachel A.B. Thomas, Julie Rodor, Sarah Finnie, Riinu Pius, Gillian M. Tannahill, Vishal Sahni, Caroline O.S. Savage, Jeremy Hughes, Ewen M. Harrison, Robert B. Henderson, Lorna P. Marson, Bryan R. Conway, Stephen J. Wigmore, Laura Denby
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Small noncoding RNAs, miRNAs (miRNAs), are emerging as important modulators in the pathogenesis of kidney disease, with potential as biomarkers of kidney disease onset, progression, or therapeutic efficacy. Bulk tissue small RNA-sequencing (sRNA-Seq)
Externí odkaz:
https://doaj.org/article/0e57397672654b13af1fc22e1d4a45d8
Autor:
Robert I Menzies, Xin Zhao, Linda J Mullins, John J Mullins, Carolynn Cairns, Nicola Wrobel, Donald R Dunbar, Matthew A Bailey, Christopher J Kenyon
Publikováno v:
Endocrine Connections, Vol 6, Iss 7, Pp 446-457 (2017)
Chronic ACTH exposure is associated with adrenal hypertrophy and steroidogenesis. The underlying molecular processes in mice have been analysed by microarray, histological and immunohistochemical techniques. Synacthen infused for 2 weeks markedly inc
Externí odkaz:
https://doaj.org/article/604365f401a94798b5d7a9d9fb79dcb4
Autor:
James O’Sullivan, Sarah Louise Finnie, Oliver Teenan, Carolynn Cairns, Andrew Boyd, Matthew A. Bailey, Adrian Thomson, Jeremy Hughes, Cécile Bénézech, Bryan Ronald Conway, Laura Denby
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Chronic kidney disease (CKD) is prevalent worldwide and is associated with significant co-morbidities including cardiovascular disease (CVD). Traditionally, the subtotal nephrectomy (remnant kidney) experimental model has been performed in rats to mo
Externí odkaz:
https://doaj.org/article/4030948669044e64aad1e6228a22ae92
Autor:
Eoin D O’Sullivan, Katie J Mylonas, Rachel Bell, Cyril Carvalho, David P Baird, Carolynn Cairns, Kevin M Gallagher, Ross Campbell, Marie Docherty, Alexander Laird, Neil C Henderson, Tamir Chandra, Kristina Kirschner, Bryan Conway, Gry H. Dihazi, Michael Zeisberg, Jeremy Hughes, Laura Denby, Hassan Dihazi, David A Ferenbach
Progressive fibrosis and maladaptive organ repair result in significant morbidity and millions of premature deaths annually. Senescent cells accumulate with ageing and after injury and are implicated in organ fibrosis, but the mechanisms by which sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a21ce3a6fc407b2f157e4b9b3959fc8e
https://doi.org/10.1101/2022.03.21.485189
https://doi.org/10.1101/2022.03.21.485189
Autor:
Dawn E W Livingstone, John J. Mullins, Kevin Stewart, John Wiseman, James W. Dear, Carmel M. Moran, Bryan R. Conway, Patrick W. F. Hadoke, Laura Denby, Robert I. Menzies, Matthew A. Bailey, Natalie K. Jones, David J. Webb, Alicja Czopek, Adrian Thomson, Carolynn Cairns, Neeraj Dhaun
Publikováno v:
Jones, N, Stewart, K, Czopek, A, Menzies, R, Thomson, A W, Moran, C, Cairns, C, Conway, B, Denby, L, Livingstone, D, Wiseman, J, Hadoke, P, Webb, D, Dhaun, N, Dear, J, Mullins, J & Bailey, M 2020, ' Endothelin-1 mediates the systemic and renal hemodynamic effects of GPR81 activation ', Hypertension . https://doi.org/10.1161/HYPERTENSIONAHA.119.14308
Hypertension (Dallas, Tex. : 1979)
Hypertension (Dallas, Tex. : 1979)
Supplemental Digital Content is available in the text.
GPR81 (G-protein-coupled receptor 81) is highly expressed in adipocytes, and activation by the endogenous ligand lactate inhibits lipolysis. GPR81 is also expressed in the heart, liver, and
GPR81 (G-protein-coupled receptor 81) is highly expressed in adipocytes, and activation by the endogenous ligand lactate inhibits lipolysis. GPR81 is also expressed in the heart, liver, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db93e9f8bfa30f8527af2997cc8ba983
https://doi.org/10.1161/hypertensionaha.119.14308
https://doi.org/10.1161/hypertensionaha.119.14308
Autor:
Laura Denby, R Thomas, Victoria Banwell, Stephen J. Wigmore, Bryan R. Conway, Katie Connor, Sarah Finnie, Ewen M Harrison, ML Monaghan, Lorna Marson, Oliver Teenan, Gillian M Tannahill, Carolynn Cairns
Publikováno v:
British Journal of Surgery. 108
Introduction MicroRNAs are promising biomarkers of renal disease, however the cellular origin of their expression is usually unclear limiting their interpretation when measured in renal biopsies and urine. We hypothesised that by first defining renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a15f32d2833b16e2a4dfac92bad8663
https://doi.org/10.1093/bjs/znab117.045
https://doi.org/10.1093/bjs/znab117.045
Autor:
Abhijeet K Choudhary, Jillian Rennie, Carolynn Cairns, Gary Borthwick, Jeremy Hughes, Nicholas M Morton, David Kluth, Bryan R Conway
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78209 (2013)
Amelioration of rodent type 2 diabetes by hemin has been linked to increased heme oxygenase (HO) activity, however alternative mechanisms have recently been proposed for its anti-diabetic effect. We sought to determine the anti-diabetic efficacy of h
Externí odkaz:
https://doaj.org/article/bb26140a62d145c9880c291e82253660
Autor:
Cécile Bénézech, Carolynn Cairns, Oliver Teenan, Katie Connor, James O’sullivan, Angela Salzano, David A. Ferenbach, Kevin Stewart, Eoin O'Sullivan, Neil C. Henderson, Peng Ding, Riinu Pius, Jeremy Hughes, Tamir Chandra, Laura Denby, Duncan Humphries, Prakash Ramachandran, Bryan R. Conway, Daniel J. Simpson
Publikováno v:
J Am Soc Nephrol
Conway, B R, O Sullivan, E, Cairns, C, O'Sullivan, J, Simpson, D, Salzano, A, Connor, K, Ding, P, Humphries, D, Stewart, K, Teenan, O, Pius, R, Henderson, N C, Benezech, C, Ramachandran, P, Ferenbach, D A, Hughes, J, Chandra, T & Denby, L 2020, ' Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease ', Journal of the American Society of Nephrology, vol. 31, no. 12, pp. 2833–2854 . https://doi.org/10.1681/ASN.2020060806
Conway, B R, O Sullivan, E, Cairns, C, O'Sullivan, J, Simpson, D, Salzano, A, Connor, K, Ding, P, Humphries, D, Stewart, K, Teenan, O, Pius, R, Henderson, N C, Benezech, C, Ramachandran, P, Ferenbach, D A, Hughes, J, Chandra, T & Denby, L 2020, ' Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease ', Journal of the American Society of Nephrology, vol. 31, no. 12, pp. 2833–2854 . https://doi.org/10.1681/ASN.2020060806
Background Little is known about the roles of myeloid cell subsets in kidney injury and in the limited ability of the organ to repair itself. Characterizing these cells based only on surface markers using flow cytometry might not provide a full pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c985622a807b7b39dbcfe20eb66ca7
https://pubmed.ncbi.nlm.nih.gov/32978267
https://pubmed.ncbi.nlm.nih.gov/32978267
Autor:
Julie Rodor, Stephen J. Wigmore, Oliver Teenan, Caroline O. S. Savage, Riinu Pius, Carolynn Cairns, Jeremy Hughes, Bryan R. Conway, Robert B Henderson, Sarah Finnie, Katie Connor, Vishal Sahni, Lorna P. Marson, Gillian M Tannahill, Laura Denby, Ewen M Harrison, Victoria Banwell, Rachel Thomas
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 24 (2020)
Connor, K L, Teenan, O, Cairns, C, Banwell, V, Thomas, R A B, Rodor, J, Finnie, S, Pius, R, Tannahill, G M, Sahni, V, Savage, C O S, Hughes, J, Harrison, E M, Henderson, R B, Marson, L P, Conway, B R, Wigmore, S J & Denby, L 2020, ' Identifying cell enriched miRNAs in kidney injury and repair ', JCI Insight, vol. 5, no. 24, e140399 . https://doi.org/10.1172/jci.insight.140399
JCI Insight, Vol 5, Iss 24 (2020)
Connor, K L, Teenan, O, Cairns, C, Banwell, V, Thomas, R A B, Rodor, J, Finnie, S, Pius, R, Tannahill, G M, Sahni, V, Savage, C O S, Hughes, J, Harrison, E M, Henderson, R B, Marson, L P, Conway, B R, Wigmore, S J & Denby, L 2020, ' Identifying cell enriched miRNAs in kidney injury and repair ', JCI Insight, vol. 5, no. 24, e140399 . https://doi.org/10.1172/jci.insight.140399
Small noncoding RNA, microRNAs (miRNAs), are emerging as important modulators in the pathogenesis of kidney disease, with potential as biomarkers of kidney disease onset, progression or possibly outcome from treatment. Bulk tissue small RNA-Sequencin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23dce84afec171299aec21c13b969bf
https://pubmed.ncbi.nlm.nih.gov/33328386
https://pubmed.ncbi.nlm.nih.gov/33328386