Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Carolyne J. Face"'
Autor:
Vivek Behera, Perry Evans, Carolyne J. Face, Nicole Hamagami, Laavanya Sankaranarayanan, Cheryl A. Keller, Belinda Giardine, Kai Tan, Ross C. Hardison, Junwei Shi, Gerd A. Blobel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Single nucleotide variants (SNVs) can affect chromatin occupancy by transcription factors (TF). Here the authors mine naturally occurring SNVs to probe cis elements and define contextual sequences that govern in vivo transcription factor chromatin oc
Externí odkaz:
https://doaj.org/article/032dd8c8b9bf4b20820beaeaca430843
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
Autor:
Ross C. Hardison, Saurabh K. Bhardwaj, Carolyne J. Face, Stella T. Chou, Christopher R. Edwards, Stephen A. Liebhaber, Gerd A. Blobel, Xianjiang Lan, Ben A. Garcia, Junwei Shi, Laavanya Sankaranarayanan, David Posocco, Simone Sidoli, Belinda Giardine, Nicole Hamagami, Osheiza Abdulmalik, Jeremy D. Grevet, Cheryl A. Keller, Xinjun Ji
Publikováno v:
Science. 361:285-290
A CRISPR screen for RBC regulators Hemoglobin in red blood cells (RBCs) carries oxygen to the tissues. Sickle cell disease is an inherited condition that involves abnormal hemoglobin. Current treatments entail modulating the level of fetal hemoglobin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5109cfea70f05b8aa327d5970f3421e6
https://doi.org/10.1126/science.aao0932
https://doi.org/10.1126/science.aao0932
Autor:
Laavanya Sankaranarayanan, Peng Huang, Paul Ginart, Aaron J. Stonestrom, Ross C. Hardison, Carolyne J. Face, Caroline Bartman, Cheryl A. Keller, Kristen S. Jahn, Chris C.-S. Hsiung, Belinda Giardine, Arjun Raj, Perry Evans, Gerd A. Blobel
During mitosis, RNA polymerase II (Pol II) and many transcription factors dissociate from chromatin, and transcription ceases globally. Transcription is known to restart in bulk by telophase, but whether de novo transcription at the mitosis–G1 tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e1e0e4c7ed48bc3709b4a3017d8a29
https://europepmc.org/articles/PMC4926865/
https://europepmc.org/articles/PMC4926865/
Publikováno v:
Blood. 128:3879-3879
Erythroid transcription factors (TFs) control gene expression programs, lineage decisions, and disease outcomes. How transcription factors contact DNA has been studied extensively in vitro, but in vivo binding characteristics are less well understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d177688a960d25ab92d6e2bcb9c96693
https://doi.org/10.1182/blood.v128.22.3879.3879
https://doi.org/10.1182/blood.v128.22.3879.3879