Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Carolyn Y, Ho"'
Autor:
Juan R. Gimeno, Iacopo Olivotto, Ana Isabel Rodríguez, Carolyn Y. Ho, Adrián Fernández, Alejandro Quiroga, Mari Angeles Espinosa, Cristina Gómez‐González, María Robledo, Lucas Tojal‐Sierra, Sharlene M. Day, Anjali Owens, Roberto Barriales‐Villa, Jose María Larrañaga, Jose Rodríguez‐Palomares, Maribel González‐del‐Hoyo, Jesús Piqueras‐Flores, Nosheen Reza, Olga Chumakova, Euan A. Ashley, Victoria Parikh, Matthew Wheeler, Daniel Jacoby, Alexandre C. Pereira, Sara Saberi, Adam S. Helms, Eduardo Villacorta, María Gallego‐Delgado, Daniel deCastro, Fernando Domínguez, Tomás Ripoll‐Vera, Esther Zorio‐Grima, José Carlos Sánchez‐Martínez, Ana García‐Álvarez, Elena Arbelo, María Victoria Mogollón, María Eugenia Fuentes‐Cañamero, Elias Grande, Carlos Peña, Lorenzo Monserrat, Neal K. Lakdawala, Dilema International Cardiomyopathy and Heart Failure Registry and international SHaRe (Sarcomeric Human Cardiomyopathy Registry) Investigators group
Publikováno v:
ESC Heart Failure, Vol 9, Iss 4, Pp 2189-2198 (2022)
Abstract Aims To describe the natural history of SARS‐CoV‐2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events. Methods and results Three hundred and five patien
Externí odkaz:
https://doaj.org/article/91483f6a810740f68b374d86c8670633
Autor:
Bobak Heydari, Alessandro Satriano, Michael Jerosch-Herold, Paul Kolm, Dong-Yun Kim, Kathleen Cheng, Yuna L. Choi, Panagiotis Antiochos, James A. White, Masliza Mahmod, Kenneth Chan, Betty Raman, Milind Y. Desai, Carolyn Y. Ho, Sarahfaye F. Dolman, Patrice Desvigne-Nickens, Martin S. Maron, Matthias G. Friedrich, Jeanette Schulz-Menger, Stefan K. Piechnik, Evan Appelbaum, William S. Weintraub, Stefan Neubauer, Christopher M. Kramer, Raymond Y. Kwong
Publikováno v:
JACC: Cardiovascular Imaging. 16:478-491
Autor:
Roddy Walsh, Francesco Mazzarotto, Nicola Whiffin, Rachel Buchan, William Midwinter, Alicja Wilk, Nicholas Li, Leanne Felkin, Nathan Ingold, Risha Govind, Mian Ahmad, Erica Mazaika, Mona Allouba, Xiaolei Zhang, Antonio de Marvao, Sharlene M. Day, Euan Ashley, Steven D. Colan, Michelle Michels, Alexandre C. Pereira, Daniel Jacoby, Carolyn Y. Ho, Kate L. Thomson, Hugh Watkins, Paul J. R. Barton, Iacopo Olivotto, Stuart A. Cook, James S. Ware
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-18 (2019)
Abstract Background International guidelines for variant interpretation in Mendelian disease set stringent criteria to report a variant as (likely) pathogenic, prioritising control of false-positive rate over test sensitivity and diagnostic yield. Ge
Externí odkaz:
https://doaj.org/article/dff8a2d61caa43d29ddbbb7e3f495ffe
Hypertrophic cardiomyopathy in myosin-binding protein C (MYBPC3) Icelandic founder mutation carriers
Autor:
Javier Diez, Begoña López, Barry J Maron, Berglind Adalsteinsdottir, Michael Burke, Ragnar Danielsen, Petr Jarolim, Jonathan Seidman, Christine E. Seidman, Carolyn Y Ho, Gunnar Th Gunnarsson
Publikováno v:
Open Heart, Vol 7, Iss 1 (2020)
ObjectiveThe myosin-binding protein C (MYBPC3) c.927-2A>G founder mutation accounts for >90% of sarcomeric hypertrophic cardiomyopathy (HCM) in Iceland. This cross-sectional observational study explored the penetrance and phenotypic burden among carr
Externí odkaz:
https://doaj.org/article/0a0ffdf5fecb4f7f9c6f2cb2df7a069d
Autor:
Louise L A M Nijenkamp, Ilse A E Bollen, Hans W M Niessen, Cris G Dos Remedios, Michelle Michels, Corrado Poggesi, Carolyn Y Ho, Diederik W D Kuster, Jolanda van der Velden
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232427 (2020)
Hypertrophic cardiomyopathy (HCM) is the most frequent genetic cardiac disease with a prevalence of 1:500 to 1:200. While most patients show obstructive HCM and a relatively stable clinical phenotype (stage II), a small group of patients progresses t
Externí odkaz:
https://doaj.org/article/591161600ceb43598f6013c5668a4b68
Autor:
Stephanie Harris, Allison L. Cirino, Christina W. Carr, Hiwot M. Tafessu, Siddharth Parmar, Jeffrey O. Greenberg, Lara E. Szent‐Gyorgyi, Roya Ghazinouri, Michelle G. Glowny, Kara McNeil, Efthalia F. Kaynor, Catherine Neumann, Christine E. Seidman, Calum A. MacRae, Carolyn Y. Ho, Neal K. Lakdawala
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 7, Iss 11, Pp n/a-n/a (2019)
Abstract Background Individuals with hypertrophic cardiomyopathy (HCM), even when asymptomatic, are at‐risk for sudden cardiac death and stroke from arrhythmias, making it imperative to identify individuals affected by this familial disorder. Conse
Externí odkaz:
https://doaj.org/article/b800619684d7498f8da08e6eedcb416f
Autor:
Sarah Abou Alaiwi, Thomas M. Roston, Peter Marstrand, Brian Lee Claggett, Victoria N. Parikh, Adam S. Helms, Jodie Ingles, Rachel Lampert, Neal K. Lakdawala, Michelle Michels, Anjali T. Owens, Joseph W. Rossano, Sara Saberi, Dominic J. Abrams, Euan A. Ashley, Christopher Semsarian, John C. Stendahl, James S. Ware, Erin Miller, Thomas D. Ryan, Mark W. Russell, Sharlene M. Day, Iacopo Olivotto, Christoffer R. Vissing, Carolyn Y. Ho
Publikováno v:
Circulation.
BACKGROUND: The development of left ventricular systolic dysfunction (LVSD) in hypertrophic cardiomyopathy (HCM) is rare but serious and associated with poor outcomes in adults. Little is known about the prevalence, predictors, and prognosis of LVSD
Autor:
Yuri Kim, Mitra Mastali, Jennifer E. Van Eyk, E. John Orav, Christoffer R. Vissing, Sharlene M. Day, Anna Axelsson Raja, Mark W. Russell, Kenneth Zahka, Harry M. Lever, Alexandre C. Pereira, Anne M. Murphy, Charles Canter, Richard G. Bach, Matthew T. Wheeler, Joseph W. Rossano, Anjali T. Owens, Henning Bundgaard, Lee Benson, Luisa Mestroni, Matthew R.G. Taylor, Amit R. Patel, Ivan Wilmot, Philip Thrush, Jonathan H. Soslow, Jason R. Becker, Christine E. Seidman, Carolyn Y. Ho, E. Kevin Hall, Lubna Choudhury, Elfriede Pahl, Kimberly Y. Lin
Publikováno v:
Circulation: Heart Failure. 16
Autor:
Carmen C. Sucharov, Bonnie Neltner, Ashley E. Pietra, Anis Karimpour-Fard, Joshen Patel, Carolyn Y. Ho, Shelley D. Miyamoto
Publikováno v:
Circulation: Heart Failure.
Background: Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy. Pathogenic germline variation in genes encoding the sarcomere is the predominant cause of disease. However diagnostic features, including unexplained left ventri
Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model
Autor:
Anna Axelsson Raja, Hiroko Wakimoto, Daniel M. DeLaughter, Daniel Reichart, Joshua Gorham, David A. Conner, Mingyue Lun, Clemens K. Probst, Norihiko Sakai, Rachel S. Knipe, Sydney B. Montesi, Barry Shea, Leonard P. Adam, Leslie A. Leinwand, William Wan, Esther Sue Choi, Eric L. Lindberg, Giannino Patone, Michela Noseda, Norbert Hübner, Christine E. Seidman, Andrew M. Tager, J. G. Seidman, Carolyn Y. Ho
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(28)
Myocardial fibrosis is a key pathologic feature of hypertrophic cardiomyopathy (HCM). However, the fibrotic pathways activated by HCM-causing sarcomere protein gene mutations are poorly defined. Because lysophosphatidic acid is a mediator of fibrosis