Genetically and functionally defined NTS to PBN brain circuits mediating anorexia

Autor: Carolyn W. Roman, Victor A. Derkach, Richard D. Palmiter

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)

Neurons in the nucleus of the solitary tract (NTS) are known to receive visceral signals from the gut during feeding. Here, the authors identify two populations of CCK- and DBH-expressing NTS neurons that work to suppress food intake when activated v

Externí odkaz: https://doaj.org/article/bcabfe1c29294cdda49df99932571845

Prenatal Metal Exposures and Infants’ Developmental Outcomes in a Navajo Population

Autor: Sara S. Nozadi, Li Li, Li Luo, Debra MacKenzie, Esther Erdei, Ruofei Du, Carolyn W. Roman, Joseph Hoover, Elena O’Donald, Courtney Burnette, Johnnye Lewis

Publikováno v: International Journal of Environmental Research and Public Health; Volume 19; Issue 1; Pages: 425
International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, Vol 19, Iss 425, p 425 (2022)

Early-life exposure to environmental toxicants can have detrimental effects on children’s neurodevelopment. In the current study, we employed a causal modeling framework to examine the direct effect of specific maternal prenatal exposures on infant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe127f1da2ac230e27bc3dc516ef163
https://doi.org/10.3390/ijerph19010425

A tale of two circuits: CCK

Autor: Carolyn W, Roman, Stephanie R, Sloat, Richard D, Palmiter

Publikováno v: Neuroscience. 358

Cholecystokinin (CCK)-expressing neurons within the nucleus of the solitary tract (CCKNTS) are responsive to satiety signals and their chemogenetic activation suppresses appetite. Optogenetic activation of CCKNTS axon terminals within either the para

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e987b8519cd605568a1f55d36b8920c
https://pubmed.ncbi.nlm.nih.gov/28684275

Parabrachial nucleus (PBn) pituitary adenylate cyclase activating polypeptide (PACAP) signaling in the amygdala: Implication for the sensory and behavioral effects of pain

Autor: Galen Missig, Karen M. Braas, Margaret A. Vizzard, Carolyn W. Roman, Sayamwong E. Hammack, Victor May

Publikováno v: Neuropharmacology. 86:38-48

The intricate relationships that associate pain, stress responses and emotional behavior have been well established. Acute stressful situations can decrease nociceptive sensations and conversely, chronic pain can enhance other pain experiences and he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777ea624e7b9daa1322c03170837d308
https://doi.org/10.1016/j.neuropharm.2014.06.022

Pituitary adenylate cyclase-activating polypeptide (PACAP) in the bed nucleus of the stria terminalis (BNST) increases corticosterone in male and female rats

Autor: I J Choi, Galen Missig, Olivia M. Harris, S. Edwards, N. Gick, Karen M. Braas, Sayamwong E. Hammack, Victor May, Erin Roelke, G. Cocchiaro, Donna J. Toufexis, Kimberly R. Lezak, Carolyn W. Roman

Publikováno v: Psychoneuroendocrinology. 45:11-20

Single nucleotide polymorphisms (SNP) in the genes for pituitary adenylate cyclase-activating peptide (PACAP) and the PAC1 receptor have been associated with several psychiatric disorders whose etiology has been associated with stressor exposure and/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e36956bfbc850cd6cafe401dd0c1d26
https://doi.org/10.1016/j.psyneuen.2014.03.007