Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Carolyn Vargas"'
Publikováno v:
Biological Chemistry.
Polymer-encapsulated nanodiscs enable membrane proteins to be investigated within a native-like lipid-bilayer environment. Unlike other bilayer-based membrane mimetics, these nanodiscs are equilibrium structures that permit lipid exchange on experime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e4f775119c8d0b26f8364f4d7983578
https://doi.org/10.1515/hsz-2022-0319
https://doi.org/10.1515/hsz-2022-0319
Cryo-Electron Microscopy Snapshots of Eukaryotic Membrane Proteins in Native Lipid-Bilayer Nanodiscs
Autor:
Kevin Janson, Fotis L. Kyrilis, Christian Tüting, Marie Alfes, Manabendra Das, Toni K. Träger, Carla Schmidt, Farzad Hamdi, Carolyn Vargas, Sandro Keller, Annette Meister, Panagiotis L. Kastritis
Publikováno v:
Biomacromolecules.
New technologies for purifying membrane-bound protein complexes in combination with cryo-electron microscopy (EM) have recently allowed the exploration of such complexes under near-native conditions. In particular, polymer-encapsulated nanodiscs enab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab3abd89c49c141b2ee713c5d49253b
https://pubmed.ncbi.nlm.nih.gov/36399657
https://pubmed.ncbi.nlm.nih.gov/36399657
Autor:
David Glueck, Anne Grethen, Manabendra Das, Ogochukwu Patricia Mmeka, Eugenio Pérez Patallo, Annette Meister, Ritu Rajender, Stefan Kins, Markus Räschle, Julian Victor, Ci Chu, Manuel Etzkorn, Zoe Köck, Frank Bernhard, Jonathan Oyebamiji Babalola, Carolyn Vargas, Sandro Keller
Publikováno v:
Small (Weinheim an der Bergstrasse, Germany). 18(47)
Membrane proteins can be examined in near-native lipid-bilayer environments with the advent of polymer-encapsulated nanodiscs. These nanodiscs self-assemble directly from cellular membranes, allowing in vitro probing of membrane proteins with techniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a0cfabf593d2fcbfba222d306701e7
https://pubmed.ncbi.nlm.nih.gov/36228092
https://pubmed.ncbi.nlm.nih.gov/36228092
Autor:
David Haselberger, Tommy Hofmann, Carolyn Vargas, Panagiotis L. Kastritis, Lisa Müller, Matthias H. Hoffmann, Sandro Keller, Annette Meister, Manabendra Das, Dariush Hinderberger, Carla Schmidt, Kevin Janson
Publikováno v:
Biomacromolecules. 22:3901-3912
Neurodegenerative disorders are among the most common diseases in modern society. However, the molecular bases of diseases such as multiple sclerosis or Charcot-Marie-Tooth disease remain far from being fully understood. Research in this field is lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a7c4aa9b4be1f0536681c39717c994
https://doi.org/10.1021/acs.biomac.1c00714
https://doi.org/10.1021/acs.biomac.1c00714
Autor:
Jonathan O. Babalola, Moheddine Wehbie, Florian Mahler, Aline Le Roy, Christine Ebel, Kenechi Kanayo Onyia, Sandro Keller, Anais Deletraz, Carolyn Vargas, Cécile Breyton, Ilham Bouchemal, Grégory Durand
Publikováno v:
Langmuir
Langmuir, American Chemical Society, 2021, 37 (6), pp.2111-2122. ⟨10.1021/acs.langmuir.0c03214⟩
Langmuir, 2021, 37 (6), pp.2111-2122. ⟨10.1021/acs.langmuir.0c03214⟩
Langmuir, American Chemical Society, 2021, 37 (6), pp.2111-2122. ⟨10.1021/acs.langmuir.0c03214⟩
Langmuir, 2021, 37 (6), pp.2111-2122. ⟨10.1021/acs.langmuir.0c03214⟩
International audience; Two new surfactants, F5OM and F5DM, were designed as partially fluorinated analogues of n-dodecyl-β-D-maltoside (DDM). The micellization properties and the morphologies of the aggregates formed by the two surfactants in water
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb734dda7a838042be15311d986f7068
https://doi.org/10.1021/acs.langmuir.0c03214
https://doi.org/10.1021/acs.langmuir.0c03214
Autor:
Benjamin Selmke, Rusha Chakraborty, Jörg Reichenwallner, Carolyn Vargas, Chen Nickolaus, Raghavan Varadarajan, Wolfgang E. Trommer, Mohammed Chakour, Sandro Keller
Publikováno v:
Applied Magnetic Resonance
Employing site-directed spin labeling (SDSL), the structure of maltose-binding protein (MBP) had previously been studied in the native state by electron paramagnetic resonance (EPR) spectroscopy. Several spin-labeled double cysteine mutants were dist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e97911e7147b52f5d5f3ce1fc3132a6
https://doi.org/10.1007/s00723-020-01232-y
https://doi.org/10.1007/s00723-020-01232-y
Publikováno v:
Small (Weinheim an der Bergstrasse, Germany). 17(49)
When membrane proteins are removed from their natural environment, the quality of the membrane-solubilizing agent used is critical for preserving their native structures and functions. Nanodiscs that retain a lipid-bilayer core around membrane protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4036257ffcf46b1c77dd6956a1908b4a
https://pubmed.ncbi.nlm.nih.gov/34674382
https://pubmed.ncbi.nlm.nih.gov/34674382
Autor:
Matthias Hoffmann, David Haselberger, Tommy Hofmann, Lisa Müller, Kevin Janson, Annette Meister, manabendra das, Carolyn Vargas, Sandro Keller, Panagiotis L. Kastritis, Carla Schmidt, Dariush Hinderberger
Here, we for the first time establish nanodiscs with the challenging lipid composition of myelin of the peripheral or central nervous systems, respectively (PNS and CNS, both containing >40% cholesterol, which so far has been thought to be detrimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b98392c574dae9482b23afa94a62238
https://doi.org/10.26434/chemrxiv.14687151
https://doi.org/10.26434/chemrxiv.14687151
Autor:
Matthias C. Hoffmann, Florian A. Schöffmann, Jana Eisermann, Manabendra Das, Dariush Hinderberger, Sandro Keller, Carolyn Vargas
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1863(10)
With this study we aim at comparing the well-known lipid membrane model system of liposomes and polymer-encapsulated nanodiscs regarding their lipid properties. Using differential scanning calorimetry (DSC) and continuous-wave electron paramagnetic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9633e91bf26adacebae6d5d727c40f04
https://pubmed.ncbi.nlm.nih.gov/34186033
https://pubmed.ncbi.nlm.nih.gov/34186033
Autor:
Cenek Kolar, Marie Rasche, Michael Tope Agbadaola, Eugenio Pérez Patallo, Sophie Weyrauch, Julia Lenz, Carolyn Vargas, Bartholomäus Danielczak, Jonathan O. Babalola, Annette Meister, Sandro Keller, Florian Mahler
Amphiphilic copolymers that directly extract membrane proteins and lipids from cellular membranes to form nanodiscs combine the advantages of harsher membrane mimics with those of a native-like membrane environment. Among the few commercial polymers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8805f0894777b58ececb9719eabce1ae
https://doi.org/10.1101/2021.03.31.437849
https://doi.org/10.1101/2021.03.31.437849