Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease

Autor: Adam R. Smith, Rebecca G. Smith, Ehsan Pishva, Eilis Hannon, Janou A. Y. Roubroeks, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Carolyn Sloan, Jonathan Mill, Daniel L. van den Hove, Katie Lunnon

Publikováno v: Clinical Epigenetics, Vol 11, Iss 1, Pp 1-13 (2019)

Abstract Background Alzheimer’s disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in Alzheimer’s disease have been unable to distinguish between DNA m

Externí odkaz: https://doaj.org/article/a2d864d64def4e4f9da5378cdfdff5c4

A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases

Autor: Adam Smith, Rajesh N. Kalaria, Carolyn Sloan, Jonathan Mill, Andrew C Robinson, Safa Al-Sarraj, Katie Lunnon, Claire Troakes, Rebecca G. Smith, Joe Burrage

Publikováno v: Smith, A R, Smith, R G, Burrage, J, Troakes, C, Al-Sarraj, S, Kalaria, R N, Sloan, C, Robinson, A C, Mill, J & Lunnon, K 2019, ' A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases ', Neurobiology of Aging, vol. 74, pp. 70-76 . https://doi.org/10.1016/j.neurobiolaging.2018.09.024
Smith, A R, Smith, R G, Burrage, J, Troakes, C, Al-Sarraj, S, Kalaria, R N, Sloan, C, Robinson, A C, Mill, J & Lunnon, K 2018, ' A cross-brain-regions study of ANK1 DNA methylation in different neurodegenerative diseases ', Neurobiology of Aging, vol. 74, pp. 70-76 . https://doi.org/10.1016/j.neurobiolaging.2018.09.024

Recent epigenome-wide association studies in Alzheimer's disease have highlighted consistent robust neuropathology-associated DNA hypermethylation of the ankyrin 1 (ANK1) gene in the cortex. The extent to which altered ANK1 DNA methylation is also as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f4a791ee68da64347e129a06b7059d
https://www.research.manchester.ac.uk/portal/en/publications/a-crossbrain-regions-study-of-ank1-dna-methylation-in-different-neurodegenerative-diseases(f54dd120-bf44-4cc2-af03-3aa51d4ea99a).html

Cerebral amyloid angiopathy, subcortical white matter disease and dementia: literature review and study in OPTIMA

Autor: Margaret, Esiri, Steven, Chance, Catharine, Joachim, Donald, Warden, Aidan, Smallwood, Carolyn, Sloan, Sharon, Christie, Gordon, Wilcock, A David, Smith

Publikováno v: Brain Pathol

Cerebral amyloid angiopathy (CAA) is of increasing clinical and research interest as the ability to detect it and its consequences by neuroimaging in living subjects has advanced. There is also increasing interest in understanding its possible role i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5e65e10ece5b395aba6f6b8397007d1f
https://pubmed.ncbi.nlm.nih.gov/25521177

TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosis and clinical phenotype

Autor: Claire Troakes, Yvonne S Davidson, Stuart Pickering-Brown, Stephen Sikkink, Jennifer C. Thompson, Imran H. Yusuf, Margaret M. Esiri, Samantha Raby, Penelope G. Foulds, Julie S. Snowden, David M. A. Mann, David Allsop, Daniel DuPlessis, Safa Al-Sarraj, Carolyn Sloan, David Neary, Andrew C Robinson, Vee P. Prasher, Hanan Amin

Publikováno v: Acta neuropathologica. 122(6)

TDP-43 immunoreactive (TDP-43-ir) pathological changes were investigated in the temporal cortex and hippocampus of 11 patients with autosomal dominant familial forms of Alzheimer's disease (FAD), 169 patients with sporadic AD [85 with early onset dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1710ba3446553abc11814d650d86f3ea
http://ora.ox.ac.uk/objects/uuid:981c5d6e-e6cb-474d-97da-41904866213b