Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Carolyn S. Wei"'
Autor:
James I. Murray, Liang Zhang, Adam Simon, Maria V. Silva Elipe, Carolyn S. Wei, Seb Caille, Andrew T. Parsons
Publikováno v:
Organic Process Research & Development. 27:198-205
Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor
Autor:
Liang Zhang, Daniel J. Griffin, Matthew G. Beaver, Laura E. Blue, Christopher J. Borths, Derek B. Brown, Seb Caille, Ying Chen, Alan H. Cherney, Brian M. Cochran, John T. Colyer, Michael T. Corbett, Tiffany L. Correll, Richard D. Crockett, Xi-Jie Dai, Peter K. Dornan, Robert P. Farrell, Simon J. Hedley, Hsiao-Wu Hsieh, Liang Huang, Seth Huggins, Min Liu, Michael A. Lovette, Kyle Quasdorf, William Powazinik, Jonathan Reifman, Jo Anna Robinson, Rahul P. Sangodkar, Sonika Sharma, Srividya Sharvan Kumar, Austin G. Smith, Gabrielle St-Pierre, Jason S. Tedrow, Oliver R. Thiel, Jonathan V. Truong, Shawn D. Walker, Carolyn S. Wei, Ashraf Wilsily, Yong Xie, Ning Yang, Andrew T. Parsons
Publikováno v:
Organic Process Research & Development. 26:3115-3125
Autor:
Xi-Jie Dai, Paul Krolikowski, James I. Murray, Carolyn S. Wei, Peter K. Dornan, Andreas R. Rötheli, Seb Caille, Oliver R. Thiel, Austin G. Smith, Andrew T. Parsons
Publikováno v:
The Journal of Organic Chemistry. 87:8437-8444
An organocatalyzed, formal (3+3) cycloaddition reaction is described for the practical synthesis of substituted pyridines. Starting from readily available enamines and enal/ynal/enone substrates, the protocol affords tri- or tetrasubstituted pyridine
Autor:
Keming Zhu, Neil A. Strotman, Yi Hsiao, Martin D. Eastgate, Carolyn S. Wei, Maxime Soumeillant, Chester E. Markwalter
Publikováno v:
The Journal of Organic Chemistry. 84:4653-4660
Unusual Pd deactivation and inhibition pathways were observed in a C-N coupling system. Irreversible catalyst deactivation involved C-H insertion of Pd into BippyPhos leading to an off-cycle palladaphosphacyclobutene. Product inhibition led to deacti
Autor:
Thomas M. Razler, Jianji Wang, Yi Hsiao, Yuping Qiu, Thorsten Rosner, Kolotuchin Sergei, Carolyn S. Wei, Carrasquillo Ronald, Andrew G. Lee, Brendan Mack, Paul C. Lobben, Jacob M. Janey, Zhongping Shi, Eric M. Simmons, Jason M. Stevens, Xinhua Qian, Eric C. Huang, Federico Lora-Gonzalez, Thomas La Porte, Steven R. Wisniewski, Geng Peng, Gregory L. Beutner, Boguslaw Mudryk, Kishta Katipally, Ye Zhu, Antonio Ramirez
Publikováno v:
Organic Letters. 20:3736-3740
A strategy to prepare compounds with multiple chirality axes, which has led to a concise total synthesis of compound 1A with complete stereocontrol, is reported.
Publikováno v:
Topics in Catalysis. 60:620-630
Homogenous transition metal-catalyzed reactions have become a mainstay in organic synthesis and are frequently employed in the discovery and manufacture of modern pharmaceutical compounds. Due to the complex, multi-variant nature of these transformat
Autor:
Richard J. Fox, Michael B. Hay, Gregory L. Beutner, Keming Zhu, Carolyn S. Wei, Lopa Bakrania, Cuniere Nicolas, Christopher S. Regens, Fanfair Dayne Dustan, Martin D. Eastgate, Chester E. Markwalter, Kristy Tran, Neil A. Strotman, Yi Hsiao, Michael Lawler, Maxime Soumeillant, Dimitri Skliar, Thorsten Rosner, Benjamin M. Cohen, Paul C. Lobben
Publikováno v:
The Journal of organic chemistry. 84(8)
The development of an improved short and efficient commercial synthesis of the JAK2 inhibitor, a complex pyrrolopyridine, BMS-911543, is described. During the discovery and development of this synthesis, a Pd-catalyzed C–H functionalization was inv
Autor:
Jacob Albrecht, Dimitri Skliar, Richard J. Fox, Keming Zhu, Kristy Tran, Bin Zheng, Monica A. Fitzgerald, Omid Soltani, Carolyn S. Wei, Martin D. Eastgate, Michael A. Schmidt, Jun Li, Michelle Mahoney
Publikováno v:
The Journal of Organic Chemistry. 80:6001-6011
BMS-911543 is a complex pyrrolopyridine investigated as a potential treatment for myeloproliferative disorders. The development of a short and efficient synthesis of this molecule is described. During the course of our studies, a Ni-mediated C-N bond
Autor:
Fanfair Dayne Dustan, David K. Leahy, Yi Hsiao, Carolyn S. Wei, Thorsten Rosner, Lopa V. Desai, Michael B. Hay
Publikováno v:
Tetrahedron. 69:5677-5684
The Pd-catalyzed α-arylation of cycloheptapyridyl ketone is a key complexity-building step in the synthesis of BMS-846372, a CGRP antagonist. A first-generation process utilized Pd(OAc)2/PtBu3·HBF4 catalyst system with a strong base NaOtBu. Althoug
Autor:
Srinivas Tummala, Geraint Davies, Qi Gao, Yi Hsiao, Omid Soltani, Martin D. Eastgate, Jacob Albrecht, Charles Pathirana, Carolyn S. Wei
Publikováno v:
Angewandte Chemie. 125:5934-5938