Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Carolyn S. Sevier"'
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101524- (2022)
Summary: This protocol describes how to characterize α-Smooth muscle actin (αSMA) spatiotemporal expression during mouse small intestinal development. Specific tissue fixation preserves αSMA arrangement in low αSMA expressing cells that are conve
Externí odkaz:
https://doaj.org/article/379cf21ccdf7450c844f80d0ee1b8386
Autor:
Jennifer M. Roscoe, Carolyn S. Sevier
Publikováno v:
Cells, Vol 9, Iss 10, p 2314 (2020)
The endoplasmic reticulum (ER) has emerged as a source of hydrogen peroxide (H2O2) and a hub for peroxide-based signaling events. Here we outline cellular sources of ER-localized peroxide, including sources within and near the ER. Focusing on three E
Externí odkaz:
https://doaj.org/article/41bc0b25dc8840c98b2ba633bf93c5ea
Autor:
Bae Gh, Tao G, Nathan R. Souchet, Carolyn S. Sevier, Natasza A. Kurpios, Taboada Ak, Gerald E. Duhamel, Jiahn Choi, Shing Hu, Aparna Mahadevan, Elysee If
SUMMARYIntestinal lacteals are the essential lymphatic channels for absorption and transport of dietary lipids and drive pathogenesis of debilitating metabolic diseases. Yet, organ-specific mechanisms linking lymphatic dysfunction to disease etiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2617050159e1e511b9cd672f030faff5
https://doi.org/10.1101/2021.06.11.447753
https://doi.org/10.1101/2021.06.11.447753
Autor:
Carolyn S. Sevier, Jennifer M Roscoe
Publikováno v:
Cells, Vol 9, Iss 2314, p 2314 (2020)
Cells
Cells
The endoplasmic reticulum (ER) has emerged as a source of hydrogen peroxide (H2O2) and a hub for peroxide-based signaling events. Here we outline cellular sources of ER-localized peroxide, including sources within and near the ER. Focusing on three E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e147b7709402fbfc7098922ff7794eda
https://www.mdpi.com/2073-4409/9/10/2314
https://www.mdpi.com/2073-4409/9/10/2314
Publikováno v:
Biochemistry. 57:1073-1086
The ATPase domain of members of the 70 kDa heat shock protein (Hsp70) family shows a high degree of sequence, structural, and functional homology across species. A broadly conserved residue within the Hsp70 ATPase domain that captured our attention i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015b7cb8e8595f004a3f139b289d16d7
https://doi.org/10.1021/acs.biochem.7b01005
https://doi.org/10.1021/acs.biochem.7b01005
Publikováno v:
Chem Res Toxicol
The concept that reactive oxygen species (ROS) are primarily toxic, mitochondria-generated molecules has persisted for decades. Here we highlight the emerging complexity for ROS-based events, emphasizing the evolving importance of the endoplasmic ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdce88096f4e441c1e2928343e147090
https://doi.org/10.1021/acs.chemrestox.8b00379
https://doi.org/10.1021/acs.chemrestox.8b00379
Autor:
Erin E. Nicklow, Carolyn S. Sevier
Publikováno v:
J Biol Chem
Cells employ a vast network of regulatory pathways to manage intracellular levels of reactive oxygen species (ROS). An effectual means used by cells to control these regulatory systems are sulfur-based redox switches, which consist of protein cystein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7ea8ba9e516b80a8e671b98e33c194
https://pubmed.ncbi.nlm.nih.gov/31806703
https://pubmed.ncbi.nlm.nih.gov/31806703
Autor:
Nathan R. Souchet, Aparna Mahadevan, Natasza A. Kurpios, Gerald E. Duhamel, Alessandra K. Taboada, Bhargav D. Sanketi, Ge Tao, Shing Hu, Gloria H. Bae, Carolyn S. Sevier, Joseph Choi, Isaac F. Elysee
Publikováno v:
Cell reports
SUMMARY Intestinal lacteals are essential lymphatic channels for absorption and transport of dietary lipids and drive the pathogenesis of debilitating metabolic diseases. However, organ-specific mechanisms linking lymphatic dysfunction to disease eti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d513947064e47a87bf6068d1b62c0c0
http://europepmc.org/articles/PMC8650168
http://europepmc.org/articles/PMC8650168
Publikováno v:
Journal of Molecular Biology. 428:4168-4184
Among the amino acids, cysteine stands apart based on its highly reactive sulfur group. In general, cysteine is underrepresented in proteins. Yet, when present, the features of cysteine often afford unique function. We have shown previously that a cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e75e435791e5097c6a18eca2e1b0843
https://doi.org/10.1016/j.jmb.2016.08.011
https://doi.org/10.1016/j.jmb.2016.08.011
Autor:
Carolyn S. Sevier, Jie Wang
Publikováno v:
Journal of Biological Chemistry. 291:7541-7557
Redox fluctuations within cells can be detrimental to cell function. To gain insight into how cells normally buffer against redox changes to maintain cell function, we have focused on elucidating the signaling pathways that serve to sense and respond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac429e3cb8f826937f2ea0dc4d5f553
https://doi.org/10.1074/jbc.m115.694810
https://doi.org/10.1074/jbc.m115.694810