Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Carolyn R. Hoyal"'
Autor:
Richard Reneland, Richard B. Roth, Ulrike Schwarz-Boeger, Stefan Kammerer, Andreas Braun, Lyn R. Griffiths, Marion Kiechle, Carolyn R. Hoyal, Matthew R. Nelson, Florian Ebner, Charles R. Cantor, Joachim Rehbock, George Marnellos
Publikováno v:
Proceedings of the National Academy of Sciences. 102:2004-2009
The development of breast cancer is a complex process that involves multiple genes at many stages, from initial cell cycle dysregulation to disease progression. To identify genetic variations that influence this process, we conducted a large-scale as
Autor:
Charles R. Cantor, Michael M. Shi, George Marnellos, Carolyn R. Hoyal, Matthew R. Nelson, Stefan Kammerer, Andreas Braun
Publikováno v:
Genome Research. 14:1664-1668
Genome-wide association studies using large numbers of bi-allelic single nucleotide polymorphisms (SNPs) have been proposed as a potentially powerful method for identifying genes involved in common diseases. To assemble a SNP collection appropriate f
Autor:
Philip N. Tsichlis, Sergio D. Catz, Carolyn R. Hoyal, Brandon Young, Jun-Hsiang Lin, Bernard M. Babior, Abel Gutierrez
Publikováno v:
Proceedings of the National Academy of Sciences. 100:5130-5135
The leukocyte NADPH oxidase catalyzes the reduction of oxygen to O \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \setlength{\oddsidemargin}
Publikováno v:
Journal of Biological Chemistry. 272:11035-11043
The leukocyte NADPH oxidase catalyzes the 1-electron reduction of oxygen to O2− at the expense of NADPH: 2 O2+ NADPH → 2 O2−+ NADP++ H+. The oxidase is dormant in resting cells but acquires activity when the cells are stimulated with a suitable
Autor:
Rikard Reneland, Andreas Braun, Stefan Kammerer, Matthew R. Nelson, Charles R. Cantor, Carolyn R. Hoyal, Kenneth Abel, Steven Mah
Publikováno v:
Autoimmunity reviews. 5(4)
The successful identification of genes involved in common human disorders is dependent upon availability of informative sample sets, validated marker panels, a high-throughput scoring technology, and a strategy for combining these resources. We have
Autor:
Karl Haeussinger, Peter Meyer, Richard B. Roth, Stefan Kammerer, Ugo Pastorino, F. Stefania Falvella, Carmen Pignatiello, Andreas Braun, Reiner Fischer, Rainer Dierkesmann, Monica Spinola, Melanie Barbara Boettger, Matthew R. Nelson, Tommaso A. Dragani, Carolyn R. Hoyal
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 24(11)
Purpose Whole-genome scan association analysis was carried out to identify genetic variants predictive of lung cancer risk in smokers and to confirm the identified variants in an independent sample. Patients and Methods A case-control study was perfo
Autor:
Steven Mah, Deborah J. Hart, Tim D. Spector, Stefan Kammerer, Maria L. Langdown, Josephine M. Atienza, Ana M. Valdes, Carolyn R. Hoyal, Andreas Braun, Richard Reneland, Michael Doherty, Proton Rahman, Matthew R. Nelson
Publikováno v:
Arthritis and rheumatism. 54(2)
Objective To perform a large-scale association analysis of single-nucleotide polymorphisms (SNPs) in patients with radiographically defined osteoarthritis (OA) of the knee. Methods We examined >25,000 SNPs located within ∼14,000 genes for associati
Autor:
Carolyn R, Hoyal, Stefan, Kammerer, Richard B, Roth, Richard, Reneland, George, Marnellos, Marion, Kiechle, Ulrike, Schwarz-Boeger, Lyn R, Griffiths, Florian, Ebner, Joachim, Rehbock, Matthew R, Nelson, Andreas, Braun
Publikováno v:
Journal of Carcinogenesis, Vol 4, Iss 1, p 13 (2005)
Journal of Carcinogenesis
Journal of Carcinogenesis
Background Several studies have identified rare genetic variations responsible for many cases of familial breast cancer but their contribution to total breast cancer incidence is relatively small. More common genetic variations with low penetrance ha
Autor:
Andreas Braun, Matthew R. Nelson, Carolyn R. Hoyal, George Marnellos, Kenneth Abel, Stefan Kammerer, Rikard Reneland
Publikováno v:
SPIE Proceedings.
The completion of the human genome sequence enables the discovery of genes involved in common human disorders. The successful identification of these genes is dependent on the availability of informative sample sets, validated marker panels, a high-t
Autor:
Richard Reneland, Matthew R. Nelson, Steven Mah, Tim D. Spector, Andreas Braun, Scott Wilson, Carolyn R. Hoyal, George Marnellos, Stefan Kammerer, Philip N. Sambrook
Publikováno v:
BMC Medical Genetics, Vol 6, Iss 1, p 9 (2005)
BMC Medical Genetics
BMC Medical Genetics
Background Fragility fractures caused by osteoporosis are a major cause of morbidity and mortality in aging populations. Bone mineral density (BMD) is a useful surrogate marker for risk of fracture and is a highly heritable trait. The genetic variant