Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Carolyn R Weiss"'
Autor:
Carolyn R Weiss, Qingdong Guan, Yanbing Ma, Gefei Qing, Charles N Bernstein, Richard J Warrington, Zhikang Peng
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119004 (2015)
Caveolin-1 (Cav-1) is a multifunctional scaffolding protein serving as a platform for the cell's signal-transduction and playing an important role in inflammation. However, its role in inflammatory bowel disease is not clear. A recent study showed th
Externí odkaz:
https://doaj.org/article/593b060139684a8893242e8b6dd92bea
Publikováno v:
Future Science OA
Aim: To develop IL-18 peptide-based virus-like particle vaccines that elicit autoantibodies against IL-18 and to evaluate the in vivo effects of the vaccines in murine colitis. Methods: Recombinant IL-18 vaccines were constructed, and the effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384d5c22453bf5b139aa7b1541a2fc62
https://pubmed.ncbi.nlm.nih.gov/31428451
https://pubmed.ncbi.nlm.nih.gov/31428451
Autor:
Xi Yang, Richard Warrington, Charles N. Bernstein, Qingdong Guan, Zhikang Peng, Gefei Qing, Shuhe Wang, Carolyn R. Weiss
Interleukin (IL)-12 and IL-23 that share subunit p40 are important cytokines in the pathogenesis of inflammatory bowel disease. We reported that mouse p40 peptide-based vaccines ameliorated intestinal inflammation in the prevention of trinitrobenzene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad56ca7daf506c57c34545528b023a2
https://europepmc.org/articles/PMC6205364/
https://europepmc.org/articles/PMC6205364/
Autor:
Qingdong Guan, Zhikang Peng, Helen A Burtnick, Gefei Qing, Yanbing Ma, Allan G. Ma, Richard Warrington, Carolyn R. Weiss
Publikováno v:
Immunotherapy. 5:1313-1322
Background: Overexpression of IL-23 has been implicated in the pathogenesis of Crohn’s disease. Using vaccines to block overexpressed endogenous cytokines has emerged as a new therapeutic strategy for the long-term treatment of the disease. Aim: We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d7a6537ca91b296a148d02b235fb86
https://doi.org/10.2217/imt.13.141
https://doi.org/10.2217/imt.13.141
Autor:
Carolyn R. Weiss, Kent T. HayGlass, Andrew J. Halayko, Allan B. Becker, Qingdong Guan, Yanbing Ma, Allan G. Ma, Richard Warrington, Zhikang Peng, Sujata Basu
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 48:540-549
We previously reported that a recombinant IL-13 peptide-based virus-like particle vaccine significantly suppressed murine acute airway allergic inflammatory responses. The impact of this strategy on the development of chronic airway inflammation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357885f3d50d2db2fa427c9f63557aa2
https://doi.org/10.1165/rcmb.2012-0060oc
https://doi.org/10.1165/rcmb.2012-0060oc
Autor:
Richard Warrington, Carolyn R. Weiss, Yanbing Ma, Lindsay G. Aboud, Z. Peng, Qingdong Guan, Gefei Qing
Publikováno v:
Clinical & Experimental Allergy. 42:1397-1405
SummaryBackground Studies have found that the IL-23/Th17 pathway plays an important role in the pathogenesis of atopic dermatitis (AD) and severe and steroid-resistant asthma. Targeting IL-23/Th17 pathway with monoclonal antibodies (mAb) has been suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b8c7504dae27a38ebe060144d4ed87
https://doi.org/10.1111/j.1365-2222.2012.04022.x
https://doi.org/10.1111/j.1365-2222.2012.04022.x
Autor:
Carolyn R. Weiss, Yanbing Ma, China-Li Hillman, Qingdong Guan, Gang Zhou, Zhikang Peng, Charles N. Bernstein, Allan G. Ma, Gefei Qing, Richard Warrington, Aiping Bai
Publikováno v:
Molecular Medicine. 17:646-656
Interleukin (IL)-12 and IL-23 both share the p40 subunit and are key cytokines in the pathogenesis of Crohn’s disease. Previously, we have developed and identified three mouse p40 peptide-based and virus-like particle vaccines. Here, we evaluated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe254771edcb0c0aaf629742cb82e9c
https://doi.org/10.2119/molmed.2010.00252
https://doi.org/10.2119/molmed.2010.00252
Autor:
Sem Moreno, Zhikang Peng, Qingdong Guan, Carolyn R. Weiss, Yanbing Ma, Richard Warrington, Gefei Qing, Lina Lu, Charles N. Bernstein
Publikováno v:
Journal of leukocyte biology. 94(4)
MDSCs, a heterogeneous population of cells that expand during many pathogenic conditions, have remarkable abilities to suppress T cell responses. Their role in murine colitis, induced by TNBS and therapeutic application, remains unclear. Murine colit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175d99a090afaf15b5fda61784526056
https://pubmed.ncbi.nlm.nih.gov/23901119
https://pubmed.ncbi.nlm.nih.gov/23901119
Publikováno v:
Immunotherapy. 4(12)
Aims: To develop an IL-17 peptide-based virus-like particle vaccine that elicits autoantibodies to IL-17 and to evaluate the effects of the vaccine in mice with experimental colitis. Materials & methods: Recombinant IL-17 vaccines were constructed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b4a3a38bf46405cf28c7db887a53bb
https://pubmed.ncbi.nlm.nih.gov/23240747
https://pubmed.ncbi.nlm.nih.gov/23240747
Autor:
Allan G. Ma, Yanbing Ma, Zhikang Peng, Michael Yong, Charles N. Bernstein, Carolyn R. Weiss, Aiping Bai, Qingdong Guan
Publikováno v:
Biochemical pharmacology. 80(11)
AMP-activated protein kinase (AMPK), a cellular energy sensor, has been reported to participate in modulating inflammatory responses, but its role in intestinal inflammation remains unclear. IBD has been characterized by excessive innate and adaptive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67968c3667346993a388055a24af1866
https://pubmed.ncbi.nlm.nih.gov/20797389
https://pubmed.ncbi.nlm.nih.gov/20797389