Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Carolyn Pendry"'
Autor:
Daniele Ouellet, Frank Henriquez, Graeme Young, Lei Fang, Royce A. Morrison, Keith W. Orford, John W. Bauman, May Ho, Cathrine Leonowens, Carolyn Pendry
Publikováno v:
British Journal of Clinical Pharmacology. 78:524-532
Aims The aim of this phase 1, single centre, open label study in four patients with solid tumours was to determine the absolute bioavailability of a 2 mg oral dose of trametinib. Trametinib is an orally bioavailable, reversible and selective alloster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6834893ac14a026e32cb253a3b925ba0
https://doi.org/10.1111/bcp.12373
https://doi.org/10.1111/bcp.12373
Autor:
Carolyn Pendry, Patricia LoRusso, Anthony W. Tolcher, Keith Orford, Kyri Papadopoulos, John W. Bauman, Donna S. Cox, Lei Fang, Amita Patnaik, Daniele Ouellet
Publikováno v:
The Journal of Clinical Pharmacology. 53:946-954
The aim of this study was to estimate the effect of a high-fat, high-calorie meal on the single-dose pharmacokinetics (PK) of trametinib, a MEK inhibitor. The design of this 2 treatment, 2 period crossover, incomplete wash-out study was influenced by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a03bff0633a14d6d47cc9c96cdfd536e
https://doi.org/10.1002/jcph.115
https://doi.org/10.1002/jcph.115
Autor:
Yanwen Qian, Sandra McGuire, Jennifer Gauvin, Mary Beth Wire, Carolyn Pendry, Andres Brainsky, Jennifer Bruce
Publikováno v:
Clinical Therapeutics. 34:699-709
Background Bioavailability of the tablet formulation of eltrombopag, an oral thrombopoietin receptor agonist indicated for the treatment of chronic immune thrombocytopenia, is reduced by chelation of polyvalent cations (eg, calcium). A powder for ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf53250e228ba9ddd9e706d94775e651
https://doi.org/10.1016/j.clinthera.2012.01.011
https://doi.org/10.1016/j.clinthera.2012.01.011
Autor:
Cathrine, Leonowens, Carolyn, Pendry, John, Bauman, Graeme C, Young, May, Ho, Frank, Henriquez, Lei, Fang, Royce A, Morrison, Keith, Orford, Daniele, Ouellet
Publikováno v:
British journal of clinical pharmacology. 78(3)
The aim of this phase 1, single centre, open label study in four patients with solid tumours was to determine the absolute bioavailability of a 2 mg oral dose of trametinib. Trametinib is an orally bioavailable, reversible and selective allosteric in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::53131a24e5e724683634a25ae5266c30
https://pubmed.ncbi.nlm.nih.gov/24606567
https://pubmed.ncbi.nlm.nih.gov/24606567
Autor:
Donna S, Cox, Kyri, Papadopoulos, Lei, Fang, John, Bauman, Patricia, LoRusso, Anthony, Tolcher, Amita, Patnaik, Carolyn, Pendry, Keith, Orford, Daniele, Ouellet
Publikováno v:
Journal of clinical pharmacology. 53(9)
The aim of this study was to estimate the effect of a high-fat, high-calorie meal on the single-dose pharmacokinetics (PK) of trametinib, a MEK inhibitor. The design of this 2 treatment, 2 period crossover, incomplete wash-out study was influenced by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef2ae1bdbb5648eef4a7fef18875f9d9
https://pubmed.ncbi.nlm.nih.gov/23893461
https://pubmed.ncbi.nlm.nih.gov/23893461
Eltrombopag is an orally bioavailable thrombopoietin receptor agonist that is approved for the treatment of chronic idiopathic thrombocytopenic purpura. It is being developed for other medical disorders that are associated with thrombocytopenia. Pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638fa00feda0b19a8648a0e2ec790c86
https://europepmc.org/articles/PMC3370749/
https://europepmc.org/articles/PMC3370749/
