Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Carolyn N. Wrobel"'
Autor:
Melodie L Knowlton, Laura M Selfors, Carolyn N Wrobel, Ting-Lei Gu, Bryan A Ballif, Steven P Gygi, Roberto Polakiewicz, Joan S Brugge
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13587 (2010)
Receptor tyrosine kinases (RTKs) activate multiple downstream cytosolic tyrosine kinases following ligand stimulation. SRC family kinases (SFKs), which are recruited to activated RTKs through SH2 domain interactions with RTK autophosphorylation sites
Externí odkaz:
https://doaj.org/article/7fc7dc0071694516b93f7d9317f8ecf4
Autor:
Andrew Warren, Carolyn N. Wrobel, Joan S. Brugge, Jogender S. Tushir, Crislyn D'Souza-Schorey, James W. Clancy
Publikováno v:
Molecular Biology of the Cell
This study shows that constitutive ARF6 activation during epithelial cyst morphogenesis promotes the formation of signaling endosomes that serve as platforms for hyperactive receptor signaling and leads to the generation of tumorigenic glandular phen
Autor:
Eugene Y Koh, Dennis C. Sgroi, Carolyn N. Wrobel, George Q. Daley, Ruwanthi N. Gunawardane, Joan S. Brugge
Publikováno v:
Cancer Research. 65:11572-11580
Cell migration and invasion are two critical cellular processes that are often deregulated during tumorigenesis. To identify factors that contribute to oncogenic progression by stimulating cell migration, we conducted a powerful retroviral based migr
The development of breast carcinomas involves a complex set of phenotypic alterations in breast epithelial cells and the surrounding microenvironment. While traditional transformation assays provide models for investigating certain aspects of the cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ed0ba7a6dd353bab1b0d6dc31d5cfb
https://europepmc.org/articles/PMC1509102/
https://europepmc.org/articles/PMC1509102/
Autor:
Eva Lin, Joan S. Brugge, Sean A. Beausoleil, Martine F. Roussel, Carolyn N. Wrobel, Jayanta Debnath
Publikováno v:
The Journal of cell biology, vol 165, iss 2
The Journal of Cell Biology
The Journal of Cell Biology
Elevated coexpression of colony-stimulating factor receptor (CSF-1R) and its ligand, CSF-1, correlates with invasiveness and poor prognosis of a variety of epithelial tumors (Kacinski, B.M. 1995. Ann. Med. 27:79–85). Apart from recruitment of macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303a71a4c62c21e0767df15b3f849286
https://escholarship.org/uc/item/01g641bb
https://escholarship.org/uc/item/01g641bb
The cdc64-1 mutation causes G 1 arrest in Saccharomyces cerevisiae corresponding to a type II Start phenotype. We report that CDC64 encodes Ala1p, an alanyl-tRNA synthetase. Thus, cdc64-1 might affect charging of tRNA Ala and thereby initiation of ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7610e9ecf30ede10e6c95f7528268c
https://europepmc.org/articles/PMC94222/
https://europepmc.org/articles/PMC94222/
Autor:
Steven P. Gygi, Joan S. Brugge, Bryan A. Ballif, Carolyn N. Wrobel, Roberto D. Polakiewicz, Melodie Knowlton, Ting-Lei Gu, Laura M. Selfors
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 10, p e13587 (2010)
PLoS ONE, Vol 5, Iss 10, p e13587 (2010)
Receptor tyrosine kinases (RTKs) activate multiple downstream cytosolic tyrosine kinases following ligand stimulation. SRC family kinases (SFKs), which are recruited to activated RTKs through SH2 domain interactions with RTK autophosphorylation sites
Publikováno v:
Journal of Mammary Gland Biology & Neoplasia; Oct2004, Vol. 9 Issue 4, p297-310, 14p
Autor:
Christopher A. Mutch, Makoto Mark Taketo, Sruthi K. Swaminathan, Carolyn N. Wrobel, Anjen Chenn
Publikováno v:
Developmental Biology. (2):285-297
Transgenic mice expressing stabilized beta-catenin in neural progenitors develop enlarged brains resulting from increased progenitor expansion. To more precisely define beta-catenin regulation of progenitor fate, we employed a conditional transgenic