Výsledky vyhledávání - "Carolyn M. Summers"

Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells

Autor: Suhong Zhang, Jeanine Jochems, Andrea L. Hammons, Alexander S. Whitehead, Ian A. Blair, Jasbir S. Arora, Carolyn M. Summers

Publikováno v: European Journal of Pharmacology. 732:60-67

EA.hy 926 cells grown under low folate conditions adopt a “pro-atherosclerotic” morphology and biochemical phenotype. Pharmacologically relevant doses of the antifolate drug methotrexate (MTX) were applied to EA.hy 926 cells maintained in normal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21735edffac5dfbb5b8c524ee1a35e5
https://doi.org/10.1016/j.ejphar.2014.03.004

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Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1

Autor: Andrea L. Hammons, Laura E. Mitchell, Colin Boreham, Helene McNulty, Alexander S. Whitehead, Jayne V. Woodside, Carolyn M. Summers, Ian S. Young, John M. Scott, James J. Strain, Liam J. Murray

Publikováno v: Hammons, A L, Summers, C M, Woodside, J, McNulty, H, Strain, J J, Young, I, Murray, L, Boreham, C A, Scott, J M, Mitchell, L E & Whitehead, A S 2009, ' Folate/homocysteine phenotypes and MTHFR 677C >T genotypes are associated with serum levels of monocyte chemoattractant protein-1 ' Clinical Immunology, vol 133, no. 1, pp. 132-137 . DOI: 10.1016/j.clim.2009.06.008

PUBLISHED
Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that recruits monocytes into the subendothelial cell layer in atherosclerotic lesions. Elevated homocysteine (hyperhomocysteinemia), which is usually associated with low-folate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3cb28a76ecf4f0c6c9182550cf79837
https://doi.org/10.1016/j.clim.2009.06.008

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Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor

Autor: Zhi Yong Lu, Carolyn M. Summers, Stephanie Khartulyari, Ian A. Blair, Joan M. Von Feldt, Alexander S. Whitehead, Megan Morales, Minghua Mei, Kristen M. Murphy, Anna Stanisławska-Sachadyn, Yuehua Huang, Laura E. Mitchell

Publikováno v: Birth Defects Research Part A: Clinical and Molecular Teratology. 82:736-741

BACKGROUND: Women with the AA genotype at the (−2518)A>G promoter polymorphism of CCL-2, which encodes the potent pro-inflammatory chemokine monocyte chemoattractant protein 1 (MCP-1), may be at increased risk for having offspring affected by spina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d840e7dfad9fb9d737115ae42be0ee
https://doi.org/10.1002/bdra.20507

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Pemetrexed alters folate phenotype and inflammatory profile in EA.hy 926 cells grown under low-folate conditions

Autor: Suhong Zhang, Andrea L. Hammons, Alexander S. Whitehead, Jeanine Jochems, Ian A. Blair, Jasbir S. Arora, Carolyn M. Summers

Publikováno v: European journal of pharmacology. 696(1-3)

Elevated homocysteine is a risk marker for several major human pathologies. Emerging evidence suggests that perturbations of folate/homocysteine metabolism can directly modify production of inflammatory mediators. Pemetrexed acts by inhibiting thymid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432143686f7dd3eb4e18e5f434e6abd4
https://pubmed.ncbi.nlm.nih.gov/22975265

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Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women

Autor: Alexander S. Whitehead, Joan M. Von Feldt, Shirley F. Baido, Ian A. Blair, Anna Stanisławska-Sachadyn, Carolyn M. Summers, Laura E. Mitchell

Publikováno v: Birth defects research. Part A, Clinical and molecular teratology. 88(8)

BACKGROUND Low folate and high homocysteine (Hcy) concentrations are associated with pregnancy-related pathologies such as spina bifida. Polymorphisms in folate/Hcy metabolic enzymes may contribute to this potentially pathogenic biochemical phenotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46204d7894a54230894b6f504e2b2620
https://pubmed.ncbi.nlm.nih.gov/20544798

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Functional polymorphisms of folate-metabolizing enzymes in relation to homocysteine concentrations in systemic lupus erythematosus

Autor: Joan M. Von Feldt, Andrew J. Cucchiara, Alexander S. Whitehead, Elisabeth Mohr, Eleni Nackos, Andrea L. Hammons, Carolyn M. Summers

Publikováno v: The Journal of rheumatology. 35(11)

ObjectiveTo determine if functional polymorphisms of folate/homocysteine pathway enzymes are associated with homocysteine concentrations and/or coronary artery calcification (CAC) scores in patients with systemic lupus erythematosus (SLE) and control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b097869698876ec1b3258621cfb710
https://pubmed.ncbi.nlm.nih.gov/18785313

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Influence of the cystathionine β-synthase 844ins68 and methylenetetrahydrofolate reductase 677C>T polymorphisms on folate and homocysteine concentrations

Autor: Jayne V. Woodside, John Yarnell, Laura E. Mitchell, Alexander S. Whitehead, Alun Evans, Andrea L. Hammons, Ian S. Young, Carolyn M. Summers

A high homocysteine, low folate phenotype is a feature of many diseases. The effect of the cystathionine beta-synthase (CBS) 844ins68 polymorphism on homocysteine and folate concentrations was examined alone and in the context of the 5,10-methylenete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadd0589614e597e4c50e8b3865177db
https://europepmc.org/articles/PMC4051220/

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