Zobrazeno 1 - 10
of 322
pro vyhledávání: '"Carolyn M. Sue"'
Autor:
Amica C. Müller-Nedebock, Marieke C. J. Dekker, Matthew J. Farrer, Nobutaka Hattori, Shen-Yang Lim, George D. Mellick, Irena Rektorová, Mohamed Salama, Artur F. S. Schuh, A. Jon Stoessl, Carolyn M. Sue, Ai Huey Tan, Rene L. Vidal, Christine Klein, Soraya Bardien
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract The biological basis of the neurodegenerative movement disorder, Parkinson’s disease (PD), is still unclear despite it being ‘discovered’ over 200 years ago in Western Medicine. Based on current PD knowledge, there are widely varying t
Externí odkaz:
https://doaj.org/article/8ef87602d608417f925cb5814711f73b
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-9 (2023)
Abstract Background and objectives Mitochondrial diseases present as multi-system disorders requiring a comprehensive multidisciplinary approach. The data on healthcare resource utilization associated with mitochondrial diseases and the clinical driv
Externí odkaz:
https://doaj.org/article/322e59d99d3d4f91a32b4fbf7c85d360
Autor:
Xiangnan Xu, Michal Lubomski, Andrew J. Holmes, Carolyn M. Sue, Ryan L. Davis, Samuel Muller, Jean Y. H. Yang
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Background Unrevealing the interplay between diet, the microbiome, and the health state could enable the design of personalized intervention strategies and improve the health and well-being of individuals. A common approach to this is to div
Externí odkaz:
https://doaj.org/article/9af087e223994c36bddf22022409bda5
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
SPG7 is the most common form of autosomal recessive hereditary spastic paraplegia (HSP). There is a lack of HSP-SPG7 human neuronal models to understand the disease mechanism and identify new drug treatments. We generated a human neuronal model of HS
Externí odkaz:
https://doaj.org/article/57be7d5bf81b48b8b7b29c84929cba12
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102325- (2023)
Summary: High-throughput imaging allows in vitro assessment of neuron morphology for screening populations under developmental, homeostatic, and/or disease conditions. Here, we present a protocol to differentiate cryopreserved human cortical neuronal
Externí odkaz:
https://doaj.org/article/9d2a0e230faa47f3ac875665ccb5c021
Autor:
Gautam Wali, Sue-Faye Siow, Erandhi Liyanage, Kishore R. Kumar, Alan Mackay-Sim, Carolyn M. Sue
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
HSP-SPAST is the most common form of hereditary spastic paraplegia (HSP), a neurodegenerative disease causing lower limb spasticity. Previous studies using HSP-SPAST patient-derived induced pluripotent stem cell cortical neurons have shown that patie
Externí odkaz:
https://doaj.org/article/3201b17da6cb45dfba36c4145e81a41f
Autor:
Sue-Faye Siow, Dennis Yeow, Laura I. Rudaks, Fangzhi Jia, Gautam Wali, Carolyn M. Sue, Kishore R. Kumar
Publikováno v:
Genes, Vol 14, Iss 9, p 1756 (2023)
Hereditary spastic paraplegia (HSP) is characterized by progressive lower limb spasticity. There is no disease-modifying treatment currently available. Therefore, standardized, validated outcome measures to facilitate clinical trials are urgently nee
Externí odkaz:
https://doaj.org/article/01eb20aafcb3495a82b1494d61592a60
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract A central need for neurodegenerative diseases is to find curative drugs for the many clinical subtypes, the causative gene for most cases being unknown. This requires the classification of disease cases at the genetic and cellular level, an
Externí odkaz:
https://doaj.org/article/8ca07526bb474194b884a6feb2839f05
Publikováno v:
Journal of Movement Disorders, Vol 14, Iss 2, Pp 157-160 (2021)
The POLG gene encodes mitochondrial DNA polymerase, and mutations in this gene cause a spectrum of disorders related to mitochondrial DNA depletion or deletion. Dystonia has only rarely been reported as an early and prominent manifestation of POLG mu
Externí odkaz:
https://doaj.org/article/9494684506784fafa011b70a1f6d38d4
Autor:
Michal Lubomski, Xiangnan Xu, Andrew J. Holmes, Samuel Muller, Jean Y. H. Yang, Ryan L. Davis, Carolyn M. Sue
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
BackgroundModels to predict Parkinson’s disease (PD) incorporating alterations of gut microbiome (GM) composition have been reported with varying success.ObjectiveTo assess the utility of GM compositional changes combined with macronutrient intake
Externí odkaz:
https://doaj.org/article/f6116057868646a6979afe52d06be907