Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Carolyn M. Porteous"'
Autor:
Monika Sharma, Anne Von Zychlinski-Kleffmann, Carolyn M. Porteous, Gregory T. Jones, Michael J.A. Williams, Sally P.A. McCormick
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 7, Pp 1318-1328 (2015)
Elevated levels of lipoprotein (a) [Lp(a)] are a well-established risk factor for developing CVD. While Lp(a) levels are thought to be independent of other plasma lipoproteins, some trials have reported a positive association between Lp(a) and HDL. W
Externí odkaz:
https://doaj.org/article/d5c665350f71421d9b8948b17e0c9634
Autor:
Sally P.A. McCormick, Sreya Taraknath, Dedreia Tull, Tanjina Kader, Carolyn M. Porteous, Gregory T. Jones, Nina Dickerhof, Vinod K. Narayana
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228415 (2020)
PLoS ONE
PLoS ONE
Ribose-cysteine is a synthetic compound designed to increase glutathione (GSH) synthesis. Low levels of GSH and the GSH-dependent enzyme, glutathione peroxidase (GPx), is associated with cardiovascular disease (CVD) in both mice and humans. Here we i
Autor:
Sally P.A. McCormick, Michael Legge, Torsten Kleffmann, Gregory T. Jones, Euan J. Rodger, Carolyn M. Porteous
Publikováno v:
BioMed Research International, Vol 2018 (2018)
BioMed Research International
BioMed Research International
Background. Mouse models of hypercholesterolaemia have been used to identify arterial proteins involved in atherosclerosis. As the liver is extremely sensitive to dyslipidemia, one might expect major changes in the abundance of liver proteins in thes
Autor:
Helena M. Cochemé, Thomas Krieg, Victoria R. Pell, Michael P. Murphy, Karl J. Shaffer, Andrew M. James, Linda Partridge, Cameron Evans, Nathan J Stanley, Ian M. Fearnley, Carolyn M. Porteous, Edward T. Chouchani, Angela Logan, Tracy A. Prime, Robin A.J. Smith, Ellen L. Robb, Sara Vidoni
Publikováno v:
Cell Metabolism
Summary The mitochondrial membrane potential (Δψm) is a major determinant and indicator of cell fate, but it is not possible to assess small changes in Δψm within cells or in vivo. To overcome this, we developed an approach that utilizes two mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b18e86426afa78fb0f80b6fe46b7629
https://hdl.handle.net/21.11116/0000-000B-817A-A
https://hdl.handle.net/21.11116/0000-000B-817A-A
Autor:
Richard C. Hartley, Andrew M. James, Irina Abakumova, Tracy A. Prime, David Gems, Robin A.J. Smith, Linda Partridge, Michael P. Murphy, Filipe Cabreiro, Jigna V. Patel, Saima Saeed, Stephen J. McQuaker, Jane E. Carré, Angela Logan, Carolyn M. Porteous, Caroline Quin, Helena M. Cochemé, Mervyn Singer, Ian M. Fearnley
Publikováno v:
Cell Metabolism
Summary Hydrogen peroxide (H2O2) is central to mitochondrial oxidative damage and redox signaling, but its roles are poorly understood due to the difficulty of measuring mitochondrial H2O2 in vivo. Here we report a ratiometric mass spectrometry probe
Autor:
Cameron Evans, Franklin I. Aigbirhio, Robin A.J. Smith, Michael P. Murphy, Angela Logan, Elizabeth C. Ledgerwood, David K. Menon, Carolyn M. Porteous
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1800:1009-1017
Background Mitochondrial dysfunction contributes to a range of pathologies, consequently there is a need to monitor mitochondrial function and to intervene pharmacologically to prevent mitochondrial damage. One approach to this is to deliver antioxid
Autor:
Torsten Kleffmann, Euan J. Rodger, Michael Legge, Greg Jones, Monika Sharma, Carolyn M. Porteous, Sally P.A. McCormick
Publikováno v:
Atherosclerosis Supplements. 32:4
Autor:
Victoria J. Adlam, Andrew M. James, Geoffrey F. Kelso, Jordi Asin-Cayuela, Thabo Mahendiran, Robin A.J. Smith, Frances H. Blaikie, Helena M. Cochemé, Carolyn M. Porteous, Abdul-Rahman B. Manas, Michael P. Murphy, Meredith F. Ross, Jan Trnka
Publikováno v:
Mitochondrion. 7:S94-S102
Mitochondrial oxidative damage contributes to a range of degenerative diseases. Ubiquinones have been shown to protect mitochondria from oxidative damage, but only a small proportion of externally administered ubiquinone is taken up by mitochondria.
Autor:
Michael P. Murphy, Ivan A. Sammut, Joanne C. Harrison, Andrew M. James, Victoria J. Adlam, Robin A.J. Smith, Carolyn M. Porteous
Publikováno v:
The FASEB Journal. 19:1088-1095
Mitochondrial oxidative damage contributes to a wide range of pathologies, including cardiovascular disorders and neurodegenerative diseases. Therefore, protecting mitochondria from oxidative damage should be an effective therapeutic strategy. Howeve
Publikováno v:
Atherosclerosis. 252:e97-e98