Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Carolyn M Roos"'
Autor:
Lawrence E. Greiten, Bin Zhang, Carolyn M. Roos, Michael Hagler, Fritz-Patrick Jahns, Jordan D. Miller
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Objective: Sirtuin deacetylases are major regulators of organismal aging, and while depletion of sirtuin 6 (SIRT6) in mice results in a profound progeroid phenotype, the role of SIRT6 in the regulation of vasomotor function is unknown. Thus, our obje
Externí odkaz:
https://doaj.org/article/56bcc90c6693472493d2278925bca958
Autor:
Carolyn M. Roos, Bin Zhang, Michael A. Hagler, Grace C. Verzosa, Runqing Huang, Elise A. Oehler, Arman Arghami, Jordan D. Miller
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Background: While a small number of studies suggest that oxidative stress has an influential role in fibrocalcific aortic valve disease (FCAVD), the roles of specific antioxidant enzymes in progression of this disease remain poorly understood. Here,
Externí odkaz:
https://doaj.org/article/b957ad7c970048dcb72e78e450e48273
Publikováno v:
Atherosclerosis. 331:31-37
Background and aims The overall goal of this study was to determine the effects of MnSOD-deficiency on vascular structure and function in hypercholesterolemic mice. Previous work suggested that increases in mitochondrial-derived reactive oxygen speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f38b3a6648061ff6b4bd931bd3fbf28
https://doi.org/10.1016/j.atherosclerosis.2021.06.005
https://doi.org/10.1016/j.atherosclerosis.2021.06.005
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Increases in vascular calcification (VC) and fibrosis are a near ubiquitous finding with aging. Here, we sought to test the hypothesis that Metformin (MET)—an AMPK activator entering large clinical trials that is thought to attenuate multimorbidity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e539a26761add0f995de69120dcf380
https://doi.org/10.1161/atvb.42.suppl_1.413
https://doi.org/10.1161/atvb.42.suppl_1.413
Autor:
Heather L, Holmes, Alison A, Stiller, Christopher J, Moore, Adriana V, Gregory, Carolyn M, Roos, Jordan D, Miller, Ryan C, Gesser, Tomasz J, Czernuszewicz, Timothy L, Kline, Michael F, Romero
Publikováno v:
Journal of visualized experiments : JoVE. (174)
Common modalities for in vivo imaging of rodents include positron emission tomography (PET), computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound (US). Each method has limitations and advantages, including availability, ease of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::850d9a6b669a4369c829e37aeba1592d
https://pubmed.ncbi.nlm.nih.gov/34612855
https://pubmed.ncbi.nlm.nih.gov/34612855
Autor:
Christopher J. Moore, Adriana Gregory, Jordan D. Miller, Alison A. Stiller, Heather L. Holmes, Carolyn M Roos, Ryan C. Gesser, Tomasz J. Czernuszewicz, Timothy L. Kline, Michael F. Romero
Publikováno v:
Journal of Visualized Experiments.
Common modalities for in vivo imaging of rodents include positron emission tomography (PET), computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound (US). Each method has limitations and advantages, including availability, ease of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753c91fbe80257b75226744868ac4c2e
https://doi.org/10.3791/62682-v
https://doi.org/10.3791/62682-v
Publikováno v:
Peptides. 133
Angiotensin II (Ang II) is an oligopeptide of the renin-angiotensin system, and Ang II-induced vascular smooth muscle cell (VSMC) proliferation is an important pathophysiological process involved in atherosclerosis; however, the underlying mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5de557b42a33d54dc1e45e5f347ee9c6
https://pubmed.ncbi.nlm.nih.gov/32827590
https://pubmed.ncbi.nlm.nih.gov/32827590
Autor:
L. Manlove, Jordan D. Miller, Sarah A. Wicher, Rodney D. Britt, A.M. Roesler, Leslie A. Smith, Christina M. Pabelick, Carolyn M Roos, Y. S. Prakash, Michael A. Thompson, Yun Hua Fang
Publikováno v:
The FASEB Journal. 33:3024-3034
Recent studies have demonstrated an effect of neurotrophins, particularly brain-derived neurotrophic factor (BDNF), on airway contractility [via increased airway smooth muscle (ASM) intracellular calcium [Ca(2+)](i)] and remodeling (ASM proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ab624f351e8c84f210fc0396104c9f
https://doi.org/10.1096/fj.201801002r
https://doi.org/10.1096/fj.201801002r
Autor:
Bei Liu, Rui-wei Guo, Shiliang Huang, Michael A. Thompson, Li-xia Yang, Y. S. Prakash, Jie Zang, Bin Zhang, Jordan D. Miller, Carolyn M Roos
Publikováno v:
Canadian Journal of Cardiology. 34:791-799
Background Na + /Ca 2+ exchange (NCX) reversal-mediated Ca 2+ entry is a critical pathway for stimulating proliferation in many cell lines. However, the role of reverse-mode NCX1 in neointima formation and atherosclerosis remains unclear. The aims of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9f36867d8589e9704585a367e8f9cd9
https://doi.org/10.1016/j.cjca.2018.01.012
https://doi.org/10.1016/j.cjca.2018.01.012
Autor:
Michael A. Thompson, Carolyn M Roos, Bin Zhang, Bei Liu, Jordan D. Miller, Rui Wei Guo, Y. S. Prakash
Publikováno v:
Channels
Store depletion has been shown to induce Ca2+ entry by Na+/Ca+ exchange (NCX) 1 reversal in proliferative vascular smooth muscle cells (VSMCs). The study objective was to investigate the role of transient receptor potential canonical (TRPC) channels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a425ef7fa7eeead2e6ee453193b2e5ad
https://doi.org/10.1080/19336950.2018.1451696
https://doi.org/10.1080/19336950.2018.1451696