Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Carolyn M Phillips"'
Autor:
Celja J Uebel, Dorian C Anderson, Lisa M Mandarino, Kevin I Manage, Stephan Aynaszyan, Carolyn M Phillips
Publikováno v:
PLoS Genetics, Vol 14, Iss 7, p e1007542 (2018)
In C. elegans, efficient RNA silencing requires small RNA amplification mediated by RNA-dependent RNA polymerases (RdRPs). RRF-1, an RdRP, and other Mutator complex proteins localize to Mutator foci, which are perinuclear germline foci that associate
Externí odkaz:
https://doaj.org/article/e9361ac6307b4d42a3453cb9fdef06ca
Autor:
Shihui Chen, Carolyn M. Phillips
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract RNA interference (RNAi) is a conserved gene silencing process that exists in diverse organisms to protect genome integrity and regulate gene expression. In C. elegans, the majority of RNAi pathway proteins localize to perinuclear, phase-sepa
Externí odkaz:
https://doaj.org/article/6192632eded642508b80f9a736723e95
Autor:
Taiowa A Montgomery, Young-Soo Rim, Chi Zhang, Robert H Dowen, Carolyn M Phillips, Sylvia E J Fischer, Gary Ruvkun
Publikováno v:
PLoS Genetics, Vol 8, Iss 4, p e1002616 (2012)
Small RNAs--including piRNAs, miRNAs, and endogenous siRNAs--bind Argonaute proteins to form RNA silencing complexes that target coding genes, transposons, and aberrant RNAs. To assess the requirements for endogenous siRNA formation and activity in C
Externí odkaz:
https://doaj.org/article/fb8ab92b94564be8b53cf0be267f40b2
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 10, Pp 3719-3728 (2020)
Externí odkaz:
https://doaj.org/article/cb97853c8ef4473d95442a824e7e6a70
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 11, Pp 3825-3832 (2019)
RNA silencing pathways play critical roles in maintaining quiescence of transposons in germ cells to promote genome integrity. However the precise mechanism by which different types of transposons are recognized by these pathways is not fully underst
Externí odkaz:
https://doaj.org/article/35ae9f1a7c5945b68c9a385eca13e259
Autor:
Alicia K. Rogers, Carolyn M. Phillips
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108279- (2020)
Summary: RNA interference (RNAi) is an essential regulatory mechanism in all animals. In Caenorhabditis elegans, several classes of small RNAs act to silence or license expression of mRNA targets. ERI-6/7 is required for the production of some endoge
Externí odkaz:
https://doaj.org/article/f74bafc2fd2c47019734710e953a049d
Publikováno v:
bioRxiv
RNA silencing pathways are complex, highly conserved, and perform widespread, critical regulatory roles. In C. elegans germlines, RNA surveillance occurs through a series of perinuclear germ granule compartments - P granules, Z granules, SIMR foci, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826f0cd02880f14c7caa17bc88d5276d
https://doi.org/10.1101/2023.05.25.542330
https://doi.org/10.1101/2023.05.25.542330
Autor:
Jan Schreier, Sabrina Dietz, Mandy Boermel, Viola Oorschot, Ann-Sophie Seistrup, Antonio M. de Jesus Domingues, Alfred W. Bronkhorst, Dieu An H. Nguyen, Stephanie Phillis, Elizabeth J. Gleason, Steven W. L’Hernault, Carolyn M. Phillips, Falk Butter, René F. Ketting
Publikováno v:
Nature Cell Biology. 24:217-229
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::014747e50341d235d64de7be4b34f272
https://doi.org/10.1038/s41556-021-00827-2
https://doi.org/10.1038/s41556-021-00827-2
Autor:
Carolyn M Phillips, Dustin L Updike
Publikováno v:
Genetics
The transparency of Caenorhabditis elegans provides a unique window to observe and study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) assemblies specific to the germline cytoplasm, and they are largely conserve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3589e98b997bb7eeb0d41f7c3ce1f4a1
https://doi.org/10.1093/genetics/iyab195
https://doi.org/10.1093/genetics/iyab195
Autor:
Alicia K Rogers, Carolyn M. Phillips
Publikováno v:
Nucleic Acids Research
Repression of cellular reprogramming in germ cells is critical to maintaining cell fate and fertility. When germ cells mis-express somatic genes they can be directly converted into other cell types, resulting in loss of totipotency and reproductive p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0948cc767919f340338fad7e71f273e3
https://doi.org/10.1093/nar/gkaa174
https://doi.org/10.1093/nar/gkaa174