Výsledky vyhledávání - "Carolyn M Jablonowski"

Akademický článek

Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor

Publikováno v: eLife, Vol 12 (2024)

Dysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how p

Externí odkaz: https://doaj.org/article/56c3296c6a1943a796dba4f0a49cdf21

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Akademický článek

Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail

Autor: Brandon R Lowe, Rajesh K Yadav, Ryan A Henry, Patrick Schreiner, Atsushi Matsuda, Alfonso G Fernandez, David Finkelstein, Margaret Campbell, Satish Kallappagoudar, Carolyn M Jablonowski, Andrew J Andrews, Yasushi Hiraoka, Janet F Partridge

Publikováno v: eLife, Vol 10 (2021)

Sequencing of cancer genomes has identified recurrent somatic mutations in histones, termed oncohistones, which are frequently poorly understood. Previously we showed that fission yeast expressing only the H3.3G34R mutant identified in aggressive ped

Externí odkaz: https://doaj.org/article/1deea5202d2c4144a85ce645ef7c9d33

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Akademický článek

Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe

Autor: Rajesh K Yadav, Carolyn M Jablonowski, Alfonso G Fernandez, Brandon R Lowe, Ryan A Henry, David Finkelstein, Kevin J Barnum, Alison L Pidoux, Yin-Ming Kuo, Jie Huang, Matthew J O’Connell, Andrew J Andrews, Arzu Onar-Thomas, Robin C Allshire, Janet F Partridge

Publikováno v: eLife, Vol 6 (2017)

Recurrent somatic mutations of H3F3A in aggressive pediatric high-grade gliomas generate K27M or G34R/V mutant histone H3.3. H3.3-G34R/V mutants are common in tumors with mutations in p53 and ATRX, an H3.3-specific chromatin remodeler. To gain insigh

Externí odkaz: https://doaj.org/article/6f07b04184fd448199fb62c77f4d0ff3

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TERT Expression in Wilms Tumor Is Regulated by Promoter Mutation or Hypermethylation, WT1, and N-MYC

Autor: Carolyn M. Jablonowski, Hyea Jin Gil, Emilia M. Pinto, Prahalathan Pichavaram, Andrew M. Fleming, Michael R. Clay, Dongli Hu, Christopher L. Morton, Shondra M. Pruett-Miller, Baranda S. Hansen, Xiang Chen, Karissa M. Dieseldorff Jones, Yanling Liu, Xiaotu Ma, Jun Yang, Andrew M. Davidoff, Gerard P. Zambetti, Andrew J. Murphy

Publikováno v: Cancers; Volume 14; Issue 7; Pages: 1655

Increased TERT mRNA is associated with disease relapse in favorable histology Wilms tumor (WT). This study sought to understand the mechanism of increased TERT expression by determining the association between TERT and WT1 and N-MYC, two proteins imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69002e87d11792851561fc73bc8e5e13

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Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail

Autor: Janet F. Partridge, Brandon R Lowe, Yasushi Hiraoka, Carolyn M Jablonowski, Alfonso G Fernandez, Andrew J. Andrews, Rajesh K. Yadav, Margaret Campbell, Atsushi Matsuda, Patrick Schreiner, Ryan A. Henry, David Finkelstein, Satish Kallappagoudar

Publikováno v: eLife, Vol 10 (2021)
eLife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5363386a4ffb88d405b41f53cc83ba81
https://doi.org/10.7554/elife.65369

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Surprising Phenotypic Diversity of Cancer-associated mutations of Gly 34 in the Histone H3 tail

Autor: Margaret Campbell, Carolyn M Jablonowski, Yasushi Hiraoka, David Finkelstein, Patrick Schreiner, Rajesh K. Yadav, Andrew J. Andrews, Atsushi Matsuda, Ryan A. Henry, Satish Kallappagoudar, Janet F. Partridge, Brandon R Lowe, Alfonso G Fernandez

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4066323a96984fe10d5f49a9d5996b21
https://doi.org/10.1101/2020.12.10.419184

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KDM5A Regulates a Translational Program that Controls p53 Protein Expression

Publikováno v: iScience
iScience, Vol 9, Iss, Pp 84-100 (2018)

Summary The p53 tumor suppressor pathway is frequently inactivated in human cancers. However, there are some cancer types without commonly recognized alterations in p53 signaling. Here we report that histone demethylase KDM5A is involved in the regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2800aec22e71b3e5bf02c6287a53228
http://europepmc.org/articles/PMC6214872

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Termination of Replication Stress Signaling via Concerted Action of the Slx4 Scaffold and the PP4 Phosphatase

Autor: Attila Balint, José Renato Rosa Cussiol, TaeHyung Kim, Marcus B. Smolka, Askar Yimit, Zhaolei Zhang, Grant W. Brown, Carolyn M Jablonowski, Susannah Oberly

Publikováno v: Genetics. 201:937-949

In response to replication stress, signaling mediated by DNA damage checkpoint kinases protects genome integrity. However, following repair or bypass of DNA lesions, checkpoint signaling needs to be terminated for continued cell cycle progression and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0126458cb6fc619c91abe10b24857224
https://doi.org/10.1534/genetics.115.181479

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