Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Carolyn L. Orthner"'
Publikováno v:
Blood. 86:436-443
Tissue factor (TF), a 46-kD glycoprotein receptor for coagulation factors VII and VIIa, is expressed on the surface of endothelial cells in response to a variety of agonists and is thought to play an important role in initiating the thrombosis associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e098c1609cbccbac34ab77cdb340379
https://doi.org/10.1182/blood.v86.2.436.bloodjournal862436
https://doi.org/10.1182/blood.v86.2.436.bloodjournal862436
Autor:
Henryk Lubon, Carolyn L. Orthner, William N. Drohan, Leonid Medved, Timothy K. Lee, Kenneth C. Ingham
Publikováno v:
Journal of Biological Chemistry. 270:13652-13659
Scanning microcalorimetry and spectrofluorimetry were applied to a study of the thermal stability and interaction of the modules within natural human protein C (PC) and recombinant protein C (rPC), a potential therapeutic anticoagulant expressed in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e639abb02831cec2d2e8778eee9e527
https://doi.org/10.1074/jbc.270.23.13652
https://doi.org/10.1074/jbc.270.23.13652
Autor:
Carolyn L. Orthner, Annemarie H. Ralston, Dan Gee, Randy Kent, Billy Kolen, J.D. McGriff, William N. Drohan
Publikováno v:
Vox Sanguinis. 69:309-318
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21f1abbbeea4b704fce55c1b1f476da3
https://doi.org/10.1159/000462862
https://doi.org/10.1159/000462862
Publikováno v:
Thrombosis and Haemostasis. 72:465-474
Activated protein C (APC) is an antithrombotic serine proteinase having anticoagulant, profibrinolytic and anti-inflammatory activities. Despite its potential clinical utility, relatively little is known about its clearance mechanisms. In the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3ebcfe295a039037749122af3115a6a
https://doi.org/10.1055/s-0038-1648890
https://doi.org/10.1055/s-0038-1648890
Publikováno v:
Thrombosis and Haemostasis. 69:441-447
SummaryActivated protein C (APC) is a serine protease which plays an important role as a naturally occurring antithrombotic enzyme. APC, which is formed by thrombin-catalyzed limited proteolysis of the zymogen protein C, functions as an anticoagulant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1d6bbf1b36303f93f45029d53c6ab73
https://doi.org/10.1055/s-0038-1651630
https://doi.org/10.1055/s-0038-1651630
Publikováno v:
Biotechnology and Bioengineering. 39:1013-1023
This study demonstrates that masking the Feb regions of a monoclonal antibody (Mab) with synthetic antigens prior to covalent immobilization efficiency. Water-soluble adducts of poly(2-methyloxazoline) polymers and a synthetic-peptide epitope for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206e2c8e70f66a921a75a5b3eb7047b6
https://doi.org/10.1002/bit.260391005
https://doi.org/10.1002/bit.260391005
Autor:
J.D. McGriff, Randy Kent, Dan M. Gee, Annemarie H. Ralston, Carolyn L. Orthner, William N. Drohan, Billy L. Kolen
Publikováno v:
Vox sanguinis. 69(4)
Activated protein C (APC) is a highly specific serine proteinase which functions as an important naturally occurring antithrombotic enzyme. APC also has anti-inflammatory properties. We have developed a large-scale process for the production of APC f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38aea291ebe0bf4a43cfc6118a5c270d
https://pubmed.ncbi.nlm.nih.gov/8751300
https://pubmed.ncbi.nlm.nih.gov/8751300
Autor:
G. Sinai-Zingde, Rapti D. Madurawe, Anuradha Subramanian, William H. Velander, Judy S. Riffle, Carolyn L. Orthner, Guneet Kumar
Publikováno v:
Biotechnology and bioengineering. 39(10)
Synthetic polymers have long been used to modify various properties of proteins such as activity and solubility. Polyethylene glycol (PEG) has been widely used to form adducts with enzymes and antibodies. In this study, the polyoxazoline family of wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde13e6a8f91db916dd6b174f509df2e
https://pubmed.ncbi.nlm.nih.gov/18600901
https://pubmed.ncbi.nlm.nih.gov/18600901
Autor:
William N. Drohan, Carolyn L. Orthner, Dudley K. Strickland, Rapti D. Madurawe, William H. Velander, F D Battey
Publikováno v:
Journal of Biological Chemistry. 264:18781-18788
Murine monoclonal antibodies, developed following immunization with human protein C, were characterized for their ability to bind antigen in the presence of either CaCl2 or excess EDTA. Three stable clones were obtained which produced antibodies that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31afd0b4278fc8e0eb13d4aa6e627bc3
https://doi.org/10.1016/s0021-9258(18)51535-0
https://doi.org/10.1016/s0021-9258(18)51535-0
Autor:
Carolyn L. Orthner, Lewis I. Pizer
Publikováno v:
Journal of Biological Chemistry. 249:3750-3755
Evidence based upon measurements of (a) the rates of radioactive CO2 production from specifically labeled [14C]glucose, and (b) the intracellular concentrations of key intermediates of the hexose monophosphate shunt indicates that the rate of glucose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4c2cdc8d358d5f62331b6bb4fa19265
https://doi.org/10.1016/s0021-9258(19)42537-4
https://doi.org/10.1016/s0021-9258(19)42537-4